Improved oral bioavailability of magnolol by using a binary mixed micelle system.

PMID:  Artif Cells Nanomed Biotechnol. 2018 ;46(sup2):668-674. Epub 2018 Sep 5. PMID: 30183380 Abstract Title:  Improved oral bioavailability of magnolol by using a binary mixed micelle system. Abstract:  The aim of this study was to prepare two novel magnolol (MO)-loaded binary mixed micelles (MO-M) using biocompatible copolymers of Soluplus (SOL) and SolutolHS15 (HS15), SOL and …

Magnolol prevents ossified tendinopathy.

PMID:  Int Immunopharmacol. 2019 May ;70:117-124. Epub 2019 Feb 22. PMID: 30798160 Abstract Title:  Magnolol prevents ossified tendinopathy by inhibiting PGE2-induced osteogenic differentiation of TDSCs. Abstract:  Magnolol is a compound that is extracted from magnolia, is used in Chinese medicine and is a type of lignan. Magnolol has various anti-inflammation, anti-proliferation and pro-autophagy effects. Ossified …

Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats.

PMID:  Brain Res Bull. 2019 Jul ;149:156-167. Epub 2019 Apr 9. PMID: 30978383 Abstract Title:  Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats. Abstract:  During critical periods of neurodevelopment, the immature brain is susceptible to neuronal hyperexcitability, alterations such as hyperthermia, hypoxia, brain trauma or a …

This research suggested that magnolol possessed a new therapeutic potential for the development of osteoarthritis.

PMID:  Front Pharmacol. 2019 ;10:393. Epub 2019 Apr 16. PMID: 31040782 Abstract Title:  The Protective Effect of Magnolol in Osteoarthritis:andStudies. Abstract:  Osteoarthritis (OA), defined as a long-term progressive joint disease, is characterized by cartilage impairment and erosion. In recent decades, magnolol, as a type of lignin extracted from, has been proved to play a potent …

Magnolol induces apoptosis in osteosarcoma cells via G0/G1 phase arrest and p53-mediated mitochondrial pathway.

PMID:  J Cell Biochem. 2019 Jun 3. Epub 2019 Jun 3. PMID: 31155771 Abstract Title:  Magnolol induces apoptosis in osteosarcoma cells via G0/G1 phase arrest and p53-mediated mitochondrial pathway. Abstract:  Osteosarcoma is a highly invasive primary malignancy of bone. Magnolol is biologically active, which shows antitumor effects in a variety of cancer cell lines. However, …

These results suggest that magnolol and honokiol are potential antifungal agents for application against plant fungal diseases.

PMID:  Molecules. 2019 Jun 6 ;24(11). Epub 2019 Jun 6. PMID: 31174300 Abstract Title:  Antifungal Effect of Magnolol and Honokiol fromonCausing Tobacco Brown Spot. Abstract:  In this study, two phenol compounds, magnolol and honokiol, were extracted fromand identified by LC-MS,H- andC-NMR. The magnolol and honokiol were shown to be effective against seven pathogenic fungi, including(Fr.) …

Insights on the multifunctional activities of magnolol.

PMID:  Biomed Res Int. 2019 ;2019:1847130. Epub 2019 May 23. PMID: 31240205 Abstract Title:  Insights on the Multifunctional Activities of Magnolol. Abstract:  Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from, has been extensively documented and shows a range …

The results suggest the promising use of magnolol in therapy for allergic asthma.

PMID:  Korean J Physiol Pharmacol. 2019 Jul ;23(4):251-261. Epub 2019 Jun 25. PMID: 31297009 Abstract Title:  Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice. Abstract:  Allergic asthma, is a common chronic inflammatory disease of the airway presenting with …

A systematic review of Calendula officinalis extract for wound healing.

PMID:  Wound Repair Regen. 2019 May 30. Epub 2019 May 30. PMID: 31145533 Abstract Title:  A systematic review of Calendula officinalis extract for wound healing. Abstract:  Use of complementary and alternative medicine for wound healing is influencing mainstream medical practice. This systematic review evaluates the role of Calendula officinalis flower extract as monotherapy compared to …

fucoxanthin is a potential D3/D4 agonist for the management of neurodegenerative diseases.

PMID:  Chem Biol Interact. 2019 Jul 16 ;310:108757. Epub 2019 Jul 16. PMID: 31323226 Abstract Title:  Characterizing fucoxanthin as a selective dopamine D/Dreceptor agonist: Relevance to Parkinson's disease. Abstract:  Fucoxanthin and fucosterol are archetypal lipid components of edible brown algae that provide several health benefits. Lately, their protective role in Aβ-induced cognitive dysfunction in animal …

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