PMID: Eur J Pharmacol. 2019 Jul 6 ;859:172528. Epub 2019 Jul 6. PMID: 31288004 Abstract Title: β-Cryptoxanthin induced anti-proliferation and apoptosis by G0/G1 arrest and AMPK signal inactivation in gastric cancer. Abstract: β-Cryptoxanthin has been associated with reduced-risk of some cancers. However, the mechanisms of β-cryptoxanthin still remain unclearly understood in gastric cancer (GC). In …
Author Archives: Taylor Mercado
Dietary β-cryptoxanthin inhibits high-refined carbohydrate diet-induced fatty liver.
PMID: J Nutr. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31212314 Abstract Title: Dietaryβ-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice. Abstract: BACKGROUND: β-Cryptoxanthin (BCX), a provitamin A carotenoid shown to protect against nonalcoholic fatty liver disease (NAFLD), can be cleaved by β-carotene-15,15'-oxygenase …
Prophylactic neuroprotective propensity of crocin against rotenone induced neurotoxicity.
PMID: Metab Brain Dis. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31214956 Abstract Title: Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence. Abstract: Previously we have demonstrated the potential neuroprotective propensity of saffron and Crocin (CR) employing a Drosophila model of Parkinsonism. Rotenone (ROT) has …
Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation.
PMID: Pharmacol Rep. 2019 Aug ;71(4):746-752. Epub 2019 Apr 16. PMID: 31220735 Abstract Title: Crocin ameliorates methotrexate-induced liver injury via inhibition of oxidative stress and inflammation in rats. Abstract: BACKGROUND: Methotrexate (MTX) is used commonly in the treatment of various cancers and inflammatory diseases; nevertheless, the associated hepatotoxicity has limited its clinical application. Crocin (CRO) …
Crocin ameliorated blood glucose, lipid abnormalities, oxidative stress, sperm characteristics and testis damage in STZ-diabetic rats.
PMID: Avicenna J Phytomed. 2019 Jul-Aug;9(4):347-361. PMID: 31309073 Abstract Title: Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats. Abstract: Objective: Chronic hyperglycemia and overproduction of reactive oxygen species (ROS) are strong predictors of the development of reproductive complications of diabetes. The present study was conducted to …
Crocin can improve oxidative stress in pancreatic cells by potentiating the anti-oxidant defense system.
PMID: J Pharmacopuncture. 2019 Jun ;22(2):83-89. Epub 2019 Jun 30. PMID: 31338247 Abstract Title: Crocin Improves Oxidative Stress by Potentiating Intrinsic Anti-Oxidant Defense Systems in Pancreatic Cells During Uncontrolled Hyperglycemia. Abstract: Introduction: Oxidative stress (OS) during uncontrolled hyperglycemia has a pivotal role in pancreatic dysfunction. Our study aimed to demonstrate that crocin can potentiate anti-oxidant …
Orally administered crocin protects against cerebral ischemia/reperfusion injury.
PMID: Front Pharmacol. 2019 ;10:440. Epub 2019 Apr 30. PMID: 31114499 Abstract Title: Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota. Abstract: Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury. The …
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Immunoregulatory and anti-inflammatory properties of Crocus sativus and its main active constituents
PMID: Iran J Basic Med Sci. 2019 Apr ;22(4):334-344. PMID: 31223464 Abstract Title: Immunoregulatory and anti-inflammatory properties of(Saffron) and its main active constituents: A review. Abstract: The medicinal uses of saffron, the dried stigmas ofL., have very long history in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of …
This review summarizes the protective action of carotenoids against the development and progression of NAFLD.
PMID: Prev Nutr Food Sci. 2019 Jun ;24(2):103-113. Epub 2019 Jun 30. PMID: 31328113 Abstract Title: Health Benefits of Carotenoids: A Role of Carotenoids in the Prevention of Non-Alcoholic Fatty Liver Disease. Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases with a prevalence of ~25% worldwide. NAFLD includes …
Chemical compositions and α-glucosidase inhibitory effects of anthocyanidins from blueberry, blackcurrant and blue honeysuckle fruits.
PMID: Food Chem. 2019 Jun 29 ;299:125102. Epub 2019 Jun 29. PMID: 31279126 Abstract Title: Chemical compositions andα-glucosidase inhibitory effects of anthocyanidins from blueberry, blackcurrant and blue honeysuckle fruits. Abstract: The chemical compositions andα-glucosidase inhibitory activities of anthocyanins extracted from blueberry, blackcurrant and blue honeysuckle fruits and their acid hydrolysates (anthocyanidins) were analysed. Those anthocyanins …
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