Author Archives: Taylor Mercado

PMID:  Anat Sci Int. 2019 Apr 4. Epub 2019 Apr 4. PMID: 30949912 Abstract Title:  The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes. Abstract:  Oxidative stress contributes to the progression of neurodegenerative diseases of the central and peripheral nervous systems, including Alzheimer's disease, Parkinson's disease, stroke, and diabetic …

Continue reading “The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes.”

PMID:  Pancreas. 2019 May/Jun;48(5):711-718. PMID: 31091220 Abstract Title:  Apigenin Decreases Acinar Cell Damage in Pancreatitis. Abstract:  OBJECTIVE: Chronic pancreatitis is the consequence of multiple episodes of recurrent acute pancreatitis (RAP). We hypothesized that apigenin can minimize the sequelae of RAP by limiting acinar cells' proinflammatory signaling pathways.METHODS: AR42J acinar cells were treated in vitro with …

Continue reading “Apigenin reduced inflammatory responses in experimental models of recurrent acute pancreatitis.”

PMID:  J BUON. 2019 Mar-Apr;24(2):488-493. PMID: 31127995 Abstract Title:  Apigenin inhibits in vitro and in vivo tumorigenesis in cisplatin-resistant colon cancer cells by inducing autophagy, programmed cell death and targeting m-TOR/PI3K/Akt signalling pathway. Abstract:  PURPOSE: Colon cancer is one of the deadly malignancies and the second most frequent cancer in the world. The development of …

Continue reading “Apigenin could inhibit the growth of cisplatin-resistant colon cancer cells in vitro and in vivo.”

PMID:  Aging (Albany NY). 2019 Jun 5 ;11(11):3668-3678. PMID: 31170089 Abstract Title:  Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling. Abstract:  The naturally occurring compound apigenin has many biological effects, including anti-inflammatory, antioxidative and anticancer effects. Although hypertrophic scar formation is a common surgical complication, there is still no good treatment for …

Continue reading “This suggests apigenin could potentially provide a new option for the treatment of hypertrophic scars.”

PMID:  J Exp Clin Cancer Res. 2019 Jun 10 ;38(1):246. Epub 2019 Jun 10. PMID: 31182131 Abstract Title:  Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis. Abstract:  BACKGROUND: Prostate cancer (PCa) is considered one of the most prevalent malignancy globally, and metastasis is a major cause of death. …

Continue reading “Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis.”

PMID:  Int J Mol Sci. 2019 Jun 27 ;20(13). Epub 2019 Jun 27. PMID: 31252615 Abstract Title:  Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression. Abstract:  Interleukin (IL)-6 plays a crucial role in the progression, invasion, and metastasis of breast cancer. Triple-negative breast cancer (TNBC) cell line MDA-MB-231 …

Continue reading “These results demonstrate that the anti-invasive effect of apigenin in MDA-MB-231 cells.”

PMID:  Anticancer Agents Med Chem. 2019 07 3. Epub 2019 Jul 3. PMID: 31272364 Abstract Title:  Apigenin-mediated Alterations in Viability and Senescence of SW480 Colorectal Cancer Cells Persist in The Presence of L-thyroxine. Abstract:  INTRODUCTION: Deregulation of Thyroid Hormones (THs) system in Colorectal Cancer (CRC) suggests that these hormones may play roles in CRC pathogenesis. …

Continue reading “Apigenin may inhibit colorectal cancer cell growth and progression through induction of apoptosis rather than cell necrosis or senescence.”

PMID:  Life Sci. 2019 Jul 4:116623. Epub 2019 Jul 4. PMID: 31279781 Abstract Title:  Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats. Abstract:  AIMS: Doxorubicin, an antibiotic belonging to anthracycline family, has been used for treatment of malignancies. Cardiotoxicity is the main adverse effect of doxorubicin. Apigenin, as a …

Continue reading “Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis.”

PMID:  In Vivo. 2019 Jul-Aug;33(4):1133-1141. PMID: 31280202 Abstract Title:  Apigenin Exerts Anti-inflammatory Effects in an Experimental Model of Acute Pancreatitis by Down-regulating TNF-α. Abstract:  BACKGROUND/AIM: This study investigated the anti-inflammatory effect of apigenin in an experimental model of acute pancreatitis. Inflammatory response was reflected by tissue expression of the cytokine TNF-α coupled with histological examination.MATERIALS …

Continue reading “Apigenin slows progression and reduces severity of acute pancreatitis.”

PMID:  Med Sci Monit. 2019 Jul 16 ;25:5280-5288. Epub 2019 Jul 16. PMID: 31309931 Abstract Title:  Apigenin Protects Against Renal Tubular Epithelial Cell Injury and Oxidative Stress by High Glucose via Regulation of NF-E2-Related Factor 2 (Nrf2) Pathway. Abstract:  BACKGROUND Diabetic nephropathy (DN) is a disease characterized by oxidative stress and apoptosis of renal tubular …

Continue reading “Apigenin protects renal tubular epithelial cells against high glucose-induced injury through suppression of oxidative stress and inflammation.”