Taylor Mercado

Triptolide sensitizes cisplatin-resistant human epithelial ovarian cancer.

PMID: J Cancer. 2019 ;10(13):3012-3020. Epub 2019 Jun 2. PMID: 31281478 Abstract Title: Triptolide sensitizes cisplatin-resistant human epithelial ovarian cancer by inhibiting the phosphorylation of AKT. Abstract: Advanced and chemotherapy-resistant ovarian cancer causes high mortality of ovarian cancer, and it is important to find safe and effective drugs to reduce the chemotherapeutic resistance of ovarian …

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Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine.

PMID: Am J Transl Res. 2019 ;11(6):3750-3760. Epub 2019 Jun 15. PMID: 31312385 Abstract Title: Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine by inhibiting TLR4/NF-κB signaling. Abstract: BACKGROUND: This study aimed to investigate roles of Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling in triptolide (TPL)-induced sensitivity of pancreatic cancer cells to …

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This data show that puerarin can protect the pancreatic β cells from apoptotic death.

PMID: Mol Biol Rep. 2019 Jun 21. Epub 2019 Jun 21. PMID: 31228042 Abstract Title: Caspase/AIF/apoptosis pathway: a new target of puerarin for diabetes mellitus therapy. Abstract: Pancreaticβ cell damage is one of the crucial factors responsible for the development of type 2 diabetes mellitus (T2DM). Previous studies have suggested that puerarin (PR) could regulate …

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Effects of puerarin on the pharmacokinetics of triptolide in rats.

PMID: Pharm Biol. 2019 Dec ;57(1):407-411. PMID: 31230510 Abstract Title: Effects of puerarin on the pharmacokinetics of triptolide in rats. Abstract: Puerarin and triptolide are sometimes used together for the treatment of disease in Chinese clinics; however, the drug-drug interaction between puerarin and triptolide is still unknown.This study investigates the effects of puerarin on the …

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Puerarin prevents high-fat diet-induced obesity by enriching Akkermansia muciniphila in the gut microbiota of mice.

PMID: PLoS One. 2019 ;14(6):e0218490. Epub 2019 Jun 24. PMID: 31233515 Abstract Title: Puerarin prevents high-fat diet-induced obesity by enriching Akkermansia muciniphila in the gut microbiota of mice. Abstract: Growing evidence indicates that the gut microbiota plays a significant role in the pathophysiological processes of obesity and its related metabolic symptoms in the host. Puerarin, …

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Puerarin alleviates liver fibrosis via inhibition of the ERK1/2 signaling pathway in thioacetamide-induced hepatic fibrosis in rats.

PMID: Exp Ther Med. 2019 Jul ;18(1):133-138. Epub 2019 Apr 30. PMID: 31258646 Abstract Title: Puerarin alleviates liver fibrosis via inhibition of the ERK1/2 signaling pathway in thioacetamide-induced hepatic fibrosis in rats. Abstract: Liver fibrosis is a complex pathological process and an early step in the progression of liver cirrhosis, which can eventually develop into …

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Puerarin suppresses cell growth and migration in HPV-positive cervical cancer cells.

PMID: Exp Ther Med. 2019 Jul ;18(1):543-549. Epub 2019 May 17. PMID: 31258692 Abstract Title: Puerarin suppresses cell growth and migration in HPV-positive cervical cancer cells by inhibiting the PI3K/mTOR signaling pathway. Abstract: Puerarin is an effective component that is present in high concentrations in theplant and is extensively distributed throughout nature. Puerarin possesses a …

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Puerarin showed upregulating effects on bone mass in ovariectomy-induced postmenopausal osteoporosis.

PMID: Curr Stem Cell Res Ther. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31269886 Abstract Title: Puerarin for OVX-induced postmenopausal osteoporosis in murine model: systematic review and meta-analysis. Abstract: AIMS/BACKGROUND: Ovariectomy (OVX)-induced murine model are widely used for post-menopausal osteoporosis study. Our current study was conducted to systematically review and critically assess the bone …

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Puerarin protects against high-fat high-sucrose diet-induced non-alcoholic fatty liver disease.

PMID: Phytother Res. 2019 Jul 4. Epub 2019 Jul 4. PMID: 31273855 Abstract Title: Puerarin protects against high-fat high-sucrose diet-induced non-alcoholic fatty liver disease by modulating PARP-1/PI3K/AKT signaling pathway and facilitating mitochondrial homeostasis. Abstract: As yet, there was no effective pharmacological therapy approved for non-alcoholic fatty liver disease (NAFLD). Here, we aimed to evaluate the …

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Puerarin attenuates hypoxia-resulted damages in neural stem cells by up-regulating microRNA-214.

PMID: Artif Cells Nanomed Biotechnol. 2019 Dec ;47(1):2746-2753. PMID: 31282213 Abstract Title: Puerarin attenuates hypoxia-resulted damages in neural stem cells by up-regulating microRNA-214. Abstract: Puerarin has been reported to be useful in protection against hypoxia-induced injury. In our current study, we attempted to explore the protective effects of puerarin against hypoxia-caused damages in neural stem …

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