PMID: Eur J Nutr. 2001 Apr ;40(2):56-65. PMID: 11518200 Abstract Title: Short-term fish oil supplementation improved innate immunity, but increased ex vivo oxidation of LDL in man–a pilot study. Abstract: BACKGROUND: Fish and fish oils are rich in the two long-chain polyunsaturated fatty acids (LCPUFAs) eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). The …
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PMID: Mutat Res. 2001 Nov 15 ;498(1-2):89-98. PMID: 11673074 Abstract Title: Anticlastogenic effect of Vitamin C on cisplatin induced chromosome aberrations in human lymphocyte cultures. Abstract: Vitamin C (ascorbic acid) is an antioxidant that can scavenge free radicals and protect cellular macromolecules, including DNA, from oxidative damage induced by different agents. The protective effect of …
PMID: Free Radic Res. 2001 Jul ;35(1):73-84. PMID: 11697119 Abstract Title: Ascorbic acid and N-acetylcysteine improve in vitro the function of lymphocytes from mice with endotoxin-induced oxidative stress. Abstract: Oxidative stress associated with reactive oxygen species (ROS) and cytokines produced by immune cells, which is involved in septic shock caused by endotoxin, can be controlled …
PMID: Toxicol In Vitro. 2001 Dec ;15(6):649-54. PMID: 11698165 Abstract Title: Role of ascorbic acid on mercuric chloride-induced genotoxicity in human blood cultures. Abstract: Efforts are made to find therapeutic agents capable of minimizing genotoxicity of various natural and man-made compounds. The genotoxicity induced by mercury compounds remains controversial. Therefore we have investigated the genotoxic …
PMID: Cytokine. 2004 Aug 21-Sep 7;27(4-5):101-6. PMID: 15271375 Abstract Title: Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Abstract: BACKGROUND: Vitamin C (ascorbic acid) is an essential water-soluble nutrient which primarily exerts its effect on immune homeostasis as physiological antioxidant. However, conflicting data exist regarding the effect of …
PMID: Zhonghua Yu Fang Yi Xue Za Zhi. 2002 Jan ;36(1):25-9. PMID: 11955344 Abstract Title: [The effect of vitamin C in oxidative modification of low-density lipoprotein induced by macrophage and copperion]. Abstract: OBJECTIVE: To study the effect of vitamin C on preventing oxidative modification of low density lipoprotein cholesterol (LDL) in vitro.METHODS: Different levels of …
PMID: Hypertension. 2003 Feb ;41(2):341-6. PMID: 12574105 Abstract Title: Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats. Abstract: Previous studies have demonstrated that oxidative stress contributes to hypertension and treatments with either antioxidant or immunosuppressive/anti-inflammatory agents improve hypertension in spontaneously hypertensive rats (SHR). The present study was performed to determine …
PMID: Blood. 2003 Jul 1 ;102(1):336-43. Epub 2003 Mar 6. PMID: 12623840 Abstract Title: Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells. Abstract: The FAS receptor-FAS ligand system is a key apoptotic pathway for cells of the immune system. Ligation of the FAS-receptor (CD95) induces apoptosis by activation of pro-caspase-8 followed by downstream …
PMID: Diabetes Metab Res Rev. 2003 Jan-Feb;19(1):60-8. PMID: 12592645 Abstract Title: Ascorbic acid supplementation restores defective leukocyte-endothelial interaction in alloxan-diabetic rats. Abstract: BACKGROUND: Defective leukocyte-endothelial interactions are observed in experimental diabetes and may reduce the capacity to mount an adequate inflammatory response. The present study investigated the effect of ascorbic acid, an inhibitor of free …
PMID: J Atheroscler Thromb. 2003 ;10(1):7-12. PMID: 12621158 Abstract Title: Ascorbic acid augments cytotoxicity induced by oxidized low-density lipoprotein. Abstract: Although ascorbic acid (ASA) is known as a water-soluble antioxidant, we found that it accelerated the cytotoxicity induced by oxidized low-density lipoprotein (OxLDL) in vitro. This suggests that ASA may enhance the oxidation of LDL …
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