Taylor Mercado

Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid.

PMID: Indian J Exp Biol. 2011 Dec ;49(12):904-8. PMID: 22403863 Abstract Title: Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid. Abstract: Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3 x 10(-3) M concentration completely …

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Parenteral vitamin C may potentially have a role in the management of sepsis and acute lung injury associated with sepsis.

PMID: Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1 ;303(1):L20-32. Epub 2012 Apr 20. PMID: 22523283 Abstract Title: Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid. Abstract: Bacterial infections of the lungs and abdomen are among the most common causes of sepsis. Abdominal peritonitis often results in acute …

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Plasma vitamin C was lower in periodontitis patients compared with controls.

PMID: J Clin Periodontol. 2012 Oct ;39(10):905-12. Epub 2012 Jul 30. PMID: 22845498 Abstract Title: Vitamin C in plasma and leucocytes in relation to periodontitis. Abstract: AIM: To test the hypothesis that vitamin C concentrations in plasma, polymorphonuclear neutrophilic leucocytes (PMNs) and peripheral blood mononuclear cells (PBMCs) are lower in periodontitis patients compared with healthy …

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This study complements the notion that Vitamin C is protective in sepsis settings.

PMID: Nutrients. 2013 Aug 9 ;5(8):3131-51. Epub 2013 Aug 9. PMID: 23939536 Abstract Title: Vitamin C: a novel regulator of neutrophil extracellular trap formation. Abstract: INTRODUCTION: Neutrophil extracellular trap (NET) formation was recently identified as a novel mechanism to kill pathogens. However, excessive NET formation in sepsis can injure host tissues. We have recently shown …

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Ascorbic acid induces osteoblast differentiation of human suspension mononuclear cells.

PMID: Cytotherapy. 2014 May ;16(5):674-82. Epub 2013 Oct 29. PMID: 24176546 Abstract Title: Ascorbic acid induces osteoblast differentiation of human suspension mononuclear cells. Abstract: BACKGROUND AIMS: Suspension mononuclear cells (MNCs) can be differentiated into osteoblasts with the induction of ascorbic acid andβ-glycerophosphate. The aim of this study was to determine the ability of suspension MNCs …

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Vitamin C and its physiological role with respect to the components of the immune system.

PMID: Vnitr Lek. 2012 Oct ;58(10):743-9. PMID: 23121060 Abstract Title: [Vitamin C and its physiological role with respect to the components of the immune system]. Abstract: Vitamin C is a water soluble micronutrient commonly found in our diet which orchestrates the function of both innate and adaptive immune system, influencing both cellular and humoral immune …

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Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections.

PMID: Indian J Clin Biochem. 2013 Oct ;28(4):314-28. Epub 2013 Sep 1. PMID: 24426232 Abstract Title: Vitamin C in disease prevention and cure: an overview. Abstract: The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is …

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Vitamin C treatment of mouse bone marrow-derived dendritic cells enhanced CD8(+) memory T cell production capacity of these cells in vivo.

PMID: Immunobiology. 2014 Jul ;219(7):554-64. Epub 2014 Mar 20. PMID: 24698552 Abstract Title: Vitamin C treatment of mouse bone marrow-derived dendritic cells enhanced CD8(+) memory T cell production capacity of these cells in vivo. Abstract: Vitamin C has been found to stimulate dendritic cells (DCs) to secrete more IL-12 and thereby drive naïve CD4(+) T …

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Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson’s disease.

PMID: Nutrition. 2015 Feb ;31(2):406-8. Epub 2014 Aug 23. PMID: 25592020 Abstract Title: Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease. Abstract: OBJECTIVES: Vitamin C is a major antioxidant and also is known as a neuromodulator in dopaminergic neurons. The aim of this study was to investigate the association between lymphocyte …

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Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy.

PMID: Cytotherapy. 2015 May ;17(5):613-20. Epub 2015 Mar 5. PMID: 25747742 Abstract Title: Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy. Abstract: BACKGROUND AIMS: Natural killer (NK) cell-based immunotherapy is a promising treatment for a variety of malignancies. However, generating sufficient cell numbers for therapy remains …

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