PMID: J Control Release. 2020 May 10 ;321:84-99. Epub 2020 Feb 5. PMID: 32035194 Abstract Title: Sustained-release Griffithsin nanoparticle-fiber composites against HIV-1 and HSV-2 infections. Abstract: Human immunodeficiency virus (HIV-1) and herpes simplex virus 2 (HSV-2) affect hundreds of millions of people worldwide. The antiviral lectin, Griffithsin (GRFT), has been shown to be both safe …
Author Archives: Taylor Mercado
Griffithsin could be used as a microbicide for HIV prevention.
PMID: Viruses. 2016 11 17 ;8(11). Epub 2016 Nov 17. PMID: 27869695 Abstract Title: Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses. Abstract: Griffithsin (GRFT), a lectin fromspecies, inhibits human immunodeficiency virus-1 (HIV-1) replication at sub-nanomolar concentrations, with limited …
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Rapid-release griffithsin fibers for dual prevention of HSV-2 and HIV-1 infections.
PMID: Antimicrob Agents Chemother. 2020 May 21 ;64(6). Epub 2020 May 21. PMID: 32229493 Abstract Title: Rapid-Release Griffithsin Fibers for Dual Prevention of HSV-2 and HIV-1 Infections. Abstract: The biologic griffithsin (GRFT) has recently emerged as a candidate to safely prevent sexually transmitted infections (STIs), including human immunodeficiency virus type 1 (HIV-1) and herpes simplex …
The lectins Griffithsin, Cyanovirin-N and Scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells
PMID: Virology. 2012 Feb 20 ;423(2):175-86. Epub 2011 Dec 29. PMID: 22209231 Abstract Title: The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells. Abstract: It is generally believed that during the sexual transmission of HIV-1, the glycan-specific DC-SIGN receptor binds the virus and mediates its transfer …
Griffithsin and carrageenan combination to target herpes simplex virus 2 and human papillomavirus.
PMID: Antimicrob Agents Chemother. 2015 Dec ;59(12):7290-8. Epub 2015 Sep 14. PMID: 26369967 Abstract Title: Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus. Abstract: Extensive preclinical evaluation of griffithsin (GRFT) has identified this lectin to be a promising broad-spectrum microbicide. We set out to explore the antiviral properties of a …
Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus
PMID: Retrovirology. 2015 Jan 23 ;12:6. Epub 2015 Jan 23. PMID: 25613831 Abstract Title: Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus. Abstract: BACKGROUND: The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently under …
Potent strategy to inhibit HIV-1 by binding both gp120 and gp41.
PMID: Antimicrob Agents Chemother. 2011 Jan ;55(1):264-75. Epub 2010 Oct 18. PMID: 20956603 Abstract Title: Potent strategy to inhibit HIV-1 by binding both gp120 and gp41. Abstract: The development of an anti-HIV microbicide is critical in the fight against the spread of HIV. It is shown here that the covalent linking of compounds that bind …
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Griffithsin inhibits nipah virus entry and fusion and can protect Syrian golden hamsters from lethal nipah virus challenge.
PMID: J Infect Dis. 2020 May 11 ;221(Supplement_4):S480-S492. PMID: 32037447 Abstract Title: Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge. Abstract: Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes fatal encephalitis and respiratory disease in humans. There is currently no approved therapeutic …
Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo
PMID: Arch Virol. 2013 Feb ;158(2):349-58. Epub 2012 Oct 7. PMID: 23053519 Abstract Title: Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo. Abstract: Griffithsin (GRFT) is a broad-spectrum antiviral protein that is effective against several glycosylated viruses. Here, we have evaluated the in vitro and in vivo antiviral activities of GRFT against …
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Meet Bill Gates – Part 4 Finale
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