COVID-19: Melatonin as a potential adjuvant treatment.

n/a PMID:  Life Sci. 2020 Mar 23:117583. Epub 2020 Mar 23. PMID: 32217117 Abstract Title:  COVID-19: Melatonin as a potential adjuvant treatment. Abstract:  This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of …

Vitamin C facilitates demethylation of the foxp3 enhancer in a tet-dependent manner.

PMID:  J Immunol. 2016 Mar 1 ;196(5):2119-31. Epub 2016 Jan 29. PMID: 26826239 Abstract Title:  Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner. Abstract:  Demethylation of CpG motifs in the Foxp3 intronic element, conserved noncoding sequence 2 (CNS2), is indispensable for the stable expression of Foxp3 in regulatory T cells (Tregs). …

Vitamin C pre-treatment enhances the antibacterial effect of cold atmospheric plasma.

PMID:  Front Cell Infect Microbiol. 2017 ;7:43. Epub 2017 Feb 22. PMID: 28275584 Abstract Title:  Vitamin C Pretreatment Enhances the Antibacterial Effect of Cold Atmospheric Plasma. Abstract:  Bacterial biofilms are three-dimensional structures containing bacterial cells enveloped in a protective polymeric matrix, which renders them highly resistant to antibiotics and the human immune system. Therefore, the …

Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells.

PMID:  J Immunol. 2005 Jun 15 ;174(12):7633-44. PMID: 15944264 Abstract Title:  Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. Abstract:  Dendritic cells (DCs) are central to T cell immunity, and many strategies have been used to manipulate DCs to modify immune responses. We investigated the …

Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1alpha.

PMID:  J Leukoc Biol. 2007 May ;81(5):1236-44. Epub 2007 Jan 30. PMID: 17264304 Abstract Title:  Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1alpha. Abstract:  Some cells, including neutrophils, accumulate high intracellular ascorbate concentrations, which suggests that they have an important function in these cells. In …

Regulatory role of vitamin E in the immune system and inflammation.

PMID:  IUBMB Life. 2019 04 ;71(4):487-494. Epub 2018 Nov 30. PMID: 30501009 Abstract Title:  Regulatory role of vitamin E in the immune system and inflammation. Abstract:  Vitamin E, a potent lipid-soluble antioxidant, found in higher concentration in immune cells compared to other cells in blood, is one of the most effective nutrients known to modulate …

This review will summarize the immunological changes observed with vitamin E intervention in animals and humans.

PMID:  Nutrients. 2018 Nov 1 ;10(11). Epub 2018 Nov 1. PMID: 30388871 Abstract Title:  The Role of Vitamin E in Immunity. Abstract:  Vitamin E is a fat-soluble antioxidant that can protect the polyunsaturated fatty acids (PUFAs) in the membrane from oxidation, regulate the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), and …

Induction of cellular and molecular Immunomodulatory pathways by vitamin E and vitamin C.

PMID:  Expert Opin Biol Ther. 2017 12 ;17(12):1539-1551. Epub 2017 Sep 14. PMID: 28905653 Abstract Title:  Induction of cellular and molecular Immunomodulatory pathways by vitamin E and vitamin C. Abstract:  Vitamins E and C are well known small molecules that have been used to maintain health for decades. Recent studies of the cellular and molecular …

Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections.

PMID:  Int Immunopharmacol. 2013 Feb ;15(2):395-9. Epub 2012 Dec 20. PMID: 23261366 Abstract Title:  Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Abstract:  OBJECTIVES: Recurrent respiratory tract infections (RRTIs) represent a very important problem in daily clinical practice because of their significant contribution to morbidity in children. Several …

Therapeutic vitamin C supplementation may be reasonable for pneumonia patients who have low vitamin C plasma levels.

PMID:  Cochrane Database Syst Rev. 2013 Aug 8(8):CD005532. Epub 2013 Aug 8. PMID: 23925826 Abstract Title:  Vitamin C for preventing and treating pneumonia. Abstract:  BACKGROUND: Pneumonia is one of the most common serious infections, causing two million deaths annually among young children in low-income countries. In high-income countries pneumonia is most significantly a problem of …

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