Taylor Mercado

Galangin inhibits tumor growth and metastasis of B16F10 melanoma.

PMID: J Cell Biochem. 2013 Jan ;114(1):152-61. PMID: 22887049 Abstract Title: Galangin inhibits tumor growth and metastasis of B16F10 melanoma. Abstract: Galangin, an active flavonoid extracted from the root of the Alpinia officinarum Hance, showed a cytotoxic effect on several cancer cell lines in vitro. However, there is no information available concerning its antimetastatic effect. …

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Galangin inhibits osteoclastic bone destruction and osteoclastogenesis.

PMID: Eur J Pharmacol. 2013 Jan 5 ;698(1-3):57-66. Epub 2012 Sep 14. PMID: 22985747 Abstract Title: The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages. Abstract: We investigated the effect of galangin, a natural flavonoid, on osteoclastic bone destruction in collagen-induced arthritis and examined …

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Galangin has the potential to be a promising agent for melanoma treatment.

PMID: Cytotechnology. 2013 May ;65(3):447-55. Epub 2012 Sep 22. PMID: 23001390 Abstract Title: Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK. Abstract: Galangin, an active flavonoid present at high concentration in Alpinia officinarum Hance and propolis, shows cytotoxicity towards several cancer cell lines, including melanoma. However, the specific …

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Anti-obesity effects of galangin, a pancreatic lipase inhibitor in cafeteria diet fed female rats.

PMID: Pharm Biol. 2013 May ;51(5):607-13. Epub 2013 Jan 31. PMID: 23363068 Abstract Title: Anti-obesity effects of galangin, a pancreatic lipase inhibitor in cafeteria diet fed female rats. Abstract: CONTEXT: Alpinia galanga Willd (Zingiberaceae) (AG) is a rhizomatous herb widely cultivated in shady regions of Malaysia, India, Indochina and Indonesia. It is used in southern …

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Galangin could be a beneficial anti-allergic inflammatory agent.

PMID: Food Chem Toxicol. 2013 Jul ;57:209-16. Epub 2013 Mar 25. PMID: 23535185 Abstract Title: Galangin attenuates mast cell-mediated allergic inflammation. Abstract: A great number of people are suffering from allergic inflammatory disease such as asthma, atopic dermatitis, and sinusitis. Therefore discovery of drugs for the treatment of these diseases is an important subject in …

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These results suggest galangin can inhibit liver fibrosis induced by carbon tetrachloride.

PMID: Environ Toxicol Pharmacol. 2013 Sep ;36(2):288-295. Epub 2013 Apr 19. PMID: 23686009 Abstract Title: Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model. Abstract: This study aimed to investigate the effects of galangin on liver fibrosis in rats induced by subcutaneous injection of carbon tetrachloride (CCl4). The administration of CCl4 …

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These results suggest that galangin induces apoptosis of HCT-15 and HT-29 human colon cancer cells.

PMID: Exp Biol Med (Maywood). 2013 Sep ;238(9):1047-54. Epub 2013 Aug 7. PMID: 23925650 Abstract Title: Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway. Abstract: Galangin is a member of flavonols and found in Alpinia officinarum, galangal root, and propolis. Previous studies have demonstrated that galangin has anti-cancer effects …

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Galangin inhibits proliferation of HepG2 cells.

PMID: Eur J Pharmacol. 2013 Oct 15 ;718(1-3):235-44. Epub 2013 Sep 9. PMID: 24028940 Abstract Title: Galangin inhibits proliferation of HepG2 cells by activating AMPK via increasing the AMP/TAN ratio in a LKB1-independent manner. Abstract: Galangin, a flavonol derived from Alpinia officinarum Hance and used as food additives in southern China, induces apoptosis and autophagy …

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Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress.

PMID: Food Chem Toxicol. 2013 Dec ;62:810-6. Epub 2013 Oct 22. PMID: 24161691 Abstract Title: Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress. Abstract: Prolonged endoplasmic reticulum (ER) stress may activate apoptotic pathways in cancer cells. It is suggested that ER stress has the potential of enhancing tumor death in cancer …

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Galangin, a dietary flavonol inhibits tumor initiation during experimental pulmonary tumorigenesis.

PMID: Arch Pharm Res. 2018 Mar ;41(3):265-275. Epub 2014 Feb 5. PMID: 24497035 Abstract Title: Galangin, a dietary flavonol inhibits tumor initiation during experimental pulmonary tumorigenesis by modulating xenobiotic enzymes and antioxidant status. Abstract: The aim of present study was to elucidate anti-initiating efficacy of galangin against benzo(a)pyrene (B(a)P)-induced lung carcinogenesis in male Swiss albino …

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