Taylor Mercado

Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway.

PMID: Toxicology. 2014 Dec 4 ;326:9-17. Epub 2014 Sep 28. PMID: 25268046 Abstract Title: Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway. Abstract: Galangin can suppress hepatocellular carcinoma (HCC) cell proliferation. In this study, we demonstrated that galangin induced autophagy by activating the transforming growth factor (TGF)-β receptor/Smad pathway and increased TGF-β …

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These results suggest that galangin elicits anti-inflammatory effects on LPS-activated macrophages.

PMID: Immunopharmacol Immunotoxicol. 2014 Dec ;36(6):426-32. Epub 2014 Oct 1. PMID: 25270721 Abstract Title: Anti-inflammatory effects of galangin on lipopolysaccharide-activated macrophages via ERK and NF-κB pathway regulation. Abstract: Inflammation is the major symptom of the innate immune response to microbial infection. Macrophages, immune response-related cells, play a role in the inflammatory response. Galangin is a …

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Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.

PMID: Chem Biol Interact. 2014 Dec 5 ;224:149-56. Epub 2014 Nov 4. PMID: 25450235 Abstract Title: Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo. Abstract: Galangin, an active flavonoid component extracted from the propolis and root of Alpinia officinarum Hance, has anti-tumor activity, but the mechanisms by …

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Galangin attenuates metastatic feature via PKC/ERK signaling pathway in TPA-treated liver cancer HepG2 cells.

PMID: Cancer Cell Int. 2015 ;15:15. Epub 2015 Feb 4. PMID: 25698902 Abstract Title: Galangin, a novel dietary flavonoid, attenuates metastatic feature via PKC/ERK signaling pathway in TPA-treated liver cancer HepG2 cells. Abstract: BACKGROUND: Galangin (3,5,7-trihydroxyflavone) is a flavonoid compound found in high concentration in lesser galangal. The objective of this study was to investigate …

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Galangin shields human keratinocytes from ultraviolet B-induced oxidative stress.

PMID: Biomol Ther (Seoul). 2015 Mar ;23(2):165-73. Epub 2015 Mar 1. PMID: 25767685 Abstract Title: Galangin (3,5,7-trihydroxyflavone) shields human keratinocytes from ultraviolet B-induced oxidative stress. Abstract: Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study …

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Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells.

PMID: Neuroscience. 2015 May 21 ;294:172-81. Epub 2015 Mar 14. PMID: 25779965 Abstract Title: Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells. Abstract: Alzheimer's disease (AD), the most common cause of dementia in aging people, is found to have a critical link with the deposition ofβ-amyloid (Aβ) in the brain. The inhibition of …

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Inhibitory effect of galangin on DNA topoisomerases in lung cancer cells.

PMID: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015 May ;40(5):479-85. PMID: 26032076 Abstract Title: [Inhibitory effect of galangin on DNA topoisomerases in lung cancer cells]. Abstract: OBJECTIVE: To explore the eff ect of galangin on DNA topoisomerases in lung cancer cells A549 and H46 as well on cell growth.METHODS: The inhibitory effect …

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Protective effect of galangin in Concanavalin A-induced hepatitis in mice.

PMID: Drug Des Devel Ther. 2015 ;9:2983-92. Epub 2015 Jun 10. PMID: 26089647 Abstract Title: Protective effect of galangin in Concanavalin A-induced hepatitis in mice. Abstract: Galangin is an active pharmacological ingredient from propolis and Alpinia officinarum Hance, and has been reported to have anti-inflammatory and antioxidative properties. The present study aims to reveal the …

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Flaxseed consumption was associated with a longer luteal phase and a higher luteal phase progesterone-to-estradiol ratio.

PMID: J Clin Endocrinol Metab. 1993 Nov ;77(5):1215-9. PMID: 8077314 Abstract Title: Effect of flax seed ingestion on the menstrual cycle. Abstract: Lignans are a group of phytochemicals shown to have weakly estrogenic and antiestrogenic properties. Two specific lignans, enterodiol and enterolactone, are absorbed after formation in the intestinal tract from plant precursors particularly abundant …

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Chia and flaxseeds display significant hypoglycemic activity.

PMID: Eur J Clin Nutr. 2017 02 ;71(2):234-238. Epub 2016 Dec 21. PMID: 28000689 Abstract Title: Comparison of flax (Linum usitatissimum) and Salba-chia (Salvia hispanica L.) seeds on postprandial glycemia and satiety in healthy individuals: a randomized, controlled, crossover study. Abstract: BACKGROUND/OBJECTIVES: Flax and Salba-chia seeds have risen in popularity owing to their favorable nutrient …

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