PMID: Mini Rev Med Chem. 2019 Oct 9. Epub 2019 Oct 9. PMID: 32134369 Abstract Title: A Review on the Pharmacokinetic Properties of Naringin and Its Therapeutic Efficacies in Respiratory Diseases. Abstract: Flavonoids are an important class of phytopharmaceuticals in plants. Naringin (naringenin- 7-O-rhamnoglucoside) is a flavanone glycoside isolated from folk herbal medicine Exocarpium Citri …
Author Archives: Taylor Mercado
The present study highlighted the therapeutic potential of naringin against bisphenol A-induced cognitive impairment and oxidative damage.
PMID: Int J Mol Cell Med. 2019 ;8(2):141-153. Epub 2019 Oct 25. PMID: 32215265 Abstract Title: Protective Effect of Naringin on Bisphenol A-Induced Cognitive Dysfunction and Oxidative Damage in Rats. Abstract: Bisphenol A (BPA) is one of the highest volume chemicals produced worldwide, which is used in many plastic industries. The present study aimed to …
Bisphenol-A exposure during gestation and lactation causes visual perception deficits.
PMID: Neuroscience. 2020 Mar 25. Epub 2020 Mar 25. PMID: 32222558 Abstract Title: Bisphenol-A exposure during gestation and lactation causes visual perception deficits in rat pups following a decrease in IL-1β expression in the primary visual cortex. Abstract: Bisphenol-A (BPA) exposure can affect cognitive functions of rodents and humans. However, whether information inputs for these …
Honokiol may be clinically applied as a drug candidate for treatment of glioblastoma patients with chemoresistance.
PMID: Molecules. 2020 Mar 23 ;25(6). Epub 2020 Mar 23. PMID: 32210117 Abstract Title: Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells. Abstract: Temozolomide (TMZ)-induced chemoresistance to human glioblastomas is a critical challenge now. Our previous studies showed that honokiol, a major bioactive constituent of(Houpo), can kill human glioblastoma cells …
Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death.
PMID: Toxicol Appl Pharmacol. 2017 08 15 ;329:128-139. Epub 2017 May 27. PMID: 28558962 Abstract Title: Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling. Abstract: Cisplatin is a chemotherapeutic agent widely used in the treatment of various cancers. However, cisplatin can induce …
Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathways.
PMID: Oncol Rep. 2017 Aug ;38(2):703-714. Epub 2017 Jun 29. PMID: 28677816 Abstract Title: Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathways. Abstract: Laryngeal cancers are mostly squamous cell carcinomas. Although targeting radio-resistant cancer cells is important for improving the treatmental efficiency, the signaling pathway- and therapeutic strategy-related to laryngeal …
Galangin suppresses hepatocellular carcinoma cell proliferation by reversing the Warburg effect.
PMID: Biomed Pharmacother. 2017 Nov ;95:1295-1300. Epub 2017 Oct 6. PMID: 28938520 Abstract Title: Galangin suppresses hepatocellular carcinoma cell proliferation by reversing the Warburg effect. Abstract: Hepatocellular carcinoma (HCC) is the sixth most common cancer. The Warburg effect is an important way by which HCC adapts to a hypoxic environment. The aim of the present …
Galangin combined with cisplatin suppresses human lung cancer.
PMID: Biomed Pharmacother. 2018 Jan ;97:213-224. Epub 2017 Nov 6. PMID: 29091869 Abstract Title: Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF-κB and Bcl-2/Bax signaling pathways. Abstract: Lung cancer represents a significant problem for public health worldwide. Galangin (GG), a natural active compound 3, 5, 7-trihydroxyflavone, is …
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Galangin induces cell death by modulating the expression of glyoxalase-1 and Nrf-2 in HeLa cells.
PMID: Chem Biol Interact. 2018 Jan 5 ;279:1-9. Epub 2017 Nov 4. PMID: 29113808 Abstract Title: Galangin induces cell death by modulating the expression of glyoxalase-1 and Nrf-2 in HeLa cells. Abstract: The present study was designed to understand the anticancer property and molecular mechanisms associated with chemo preventive effects of galangin. The anticancer effect …
Galangin protects human rheumatoid arthritis fibroblast‑like synoviocytes via suppression of the NF‑κB/NLRP3 pathway.
PMID: Mol Med Rep. 2018 Oct ;18(4):3619-3624. Epub 2018 Aug 22. PMID: 30152847 Abstract Title: Galangin protects human rheumatoid arthritis fibroblast‑like synoviocytes via suppression of the NF‑κB/NLRP3 pathway. Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease that significantly affects patient quality of life. Galangin is an extract with multiple health benefits, including anti‑oxidative, anti‑proliferative, …
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