PMID: J Cell Physiol. 2019 Feb 11. Epub 2019 Feb 11. PMID: 30741414 Abstract Title: Galangin ameliorates cardiac remodeling via the MEK1/2-ERK1/2 and PI3K-AKT pathways. Abstract: Cardiac remodeling is associated with inflammation and apoptosis. Galangin, as a natural flavonol, has the potent function of regulating inflammation and apoptosis, which are factors related to cardiac remodeling. …
Author Archives: Taylor Mercado
Galangin suppresses renal inflammation.
PMID: Biomed Res Int. 2019 ;2019:3018357. Epub 2019 May 26. PMID: 31240210 Abstract Title: Galangin Suppresses Renal Inflammation via the Inhibition of NF-B, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells. Abstract: Renal inflammation can result in renal injury. Uric acid (UA) is the final product of purine metabolism in humans and …
Galangin inhibits epithelial-mesenchymal transition and angiogenesis by downregulating CD44 in glioma.
PMID: J Cancer. 2019 ;10(19):4499-4508. Epub 2019 Jul 25. PMID: 31528214 Abstract Title: Galangin inhibits epithelial-mesenchymal transition and angiogenesis by downregulating CD44 in glioma. Abstract: Galangin (3,5,7‑trihydroxyflavone), a natural flavonoid present in plants, has been reported to possess anticancer properties in various types of cancers comprising glioma. The underlying mechanism, however, has not been fully …
The natural flavonoid galangin elicits apoptosis, pyroptosis, and autophagy in glioblastoma.
PMID: Front Oncol. 2019 ;9:942. Epub 2019 Sep 27. PMID: 31612107 Abstract Title: The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma. Abstract: Galangin (GG), a flavonoid, elicits a potent antitumor activity in diverse cancers. Here, we evaluated the efficacy of GG in the treatment of human glioblastoma multiforme (GBM) and investigated the …
Protective effects of galangin against H2O2-induced aging via the IGF-1 signaling pathway in human dermal fibroblasts.
PMID: Environ Toxicol. 2020 Feb ;35(2):115-123. Epub 2019 Sep 30. PMID: 31566298 Abstract Title: Protective effects of galangin against HO-induced aging via the IGF-1 signaling pathway in human dermal fibroblasts. Abstract: Galangin, a natural flavonol, has anti-inflammatory and antioxidative potential. However, the cytoprotective effects of galangin against oxidative-induced aging in human fibroblasts have not been …
These results support the use of galangin in the prevention of ulcerative colitis.
PMID: Nutrients. 2020 Jan 29 ;12(2). Epub 2020 Jan 29. PMID: 32013062 Abstract Title: Galangin Protects against Symptoms of Dextran Sodium Sulfate-induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota. Abstract: Galangin is a natural flavonoid that has been reported to provide substantial health benefits. Nevertheless, little is known about the potential effects …
Galangin increases ERK1/2 phosphorylation to decrease ADAM9 expression and prevents invasion in A172 glioma cells.
PMID: Mol Med Rep. 2018 Jan ;17(1):667-673. Epub 2017 Oct 27. PMID: 29115634 Abstract Title: Galangin increases ERK1/2 phosphorylation to decrease ADAM9 expression and prevents invasion in A172 glioma cells. Abstract: Galangin (3,5,7‑trihydroxyflavone), is a natural flavonoid present in plants. Galangin is reported to exhibit anti‑cancer properties against various cancer types. The aim of the …
Galangin inhibits the cell progression and induces cell apoptosis through activating PTEN and Caspase-3 pathways in retinoblastoma.
PMID: Biomed Pharmacother. 2018 Jan ;97:851-863. Epub 2017 Nov 7. PMID: 29136761 Abstract Title: Galangin inhibits the cell progression and induces cell apoptosis through activating PTEN and Caspase-3 pathways in retinoblastoma. Abstract: Retinoblastoma is reported as a rare cancer that occurs during childhood. Although several treatments are available for retinoblastoma, there is a need for …
Galangin has a role in protecting dopaminergic neurons by inhibiting microglial activation.
PMID: Int J Mol Sci. 2017 Dec 21 ;19(1). Epub 2017 Dec 21. PMID: 29267220 Abstract Title: Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. Abstract: Parkinson's disease (PD) is caused by the loss of dopaminergic (DA) neurons in the midbrain substantia nigra (SN). Neuroinflammation, which is …
Galangin induces p53-independent S-phase arrest and apoptosis in human nasopharyngeal carcinoma cells.
PMID: Anticancer Res. 2018 03 ;38(3):1377-1389. PMID: 29491062 Abstract Title: Galangin Induces p53-independent S-phase Arrest and Apoptosis in Human Nasopharyngeal Carcinoma Cells Through Inhibiting PI3K-AKT Signaling Pathway. Abstract: BACKGROUND/AIM: Anti-cancer activity of 3,5,7-trihydroxyflavone (galangin) has been documented in a variety of cancer types; however, its effect on human nasopharyngeal carcinoma (NPC) cells remains undetermined.MATERIALS AND …
Health Time 