PMID: J Nutr Biochem. 2019 Oct ;72:108219. Epub 2019 Jul 30. PMID: 31473507 Abstract Title: Sulforaphane inhibits epithelial-mesenchymal transition by activating extracellular signal-regulated kinase 5 in lung cancer cells. Abstract: Epithelial-mesenchymal transition (EMT) contributes to the initiation, invasion, metastasis and drug resistance of cancer. The function of extracellular signal-regulated kinase 5 (ERK5) in lung cancer …
Author Archives: Taylor Mercado
Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane.
PMID: Carcinogenesis. 2019 Dec 31 ;40(12):1545-1556. PMID: 31555797 Abstract Title: Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane. Abstract: Inhibition of metabolic re-programming represents an attractive approach for prevention of prostate cancer. Studies have implicated increased synthesis of fatty acids or glycolysis in pathogenesis of human prostate cancers. We have shown …
Sulforaphane enhances apoptosis induced by Lactobacillus pentosus strain S-PT84 via the TNFα pathway in human colon cancer cells.
PMID: Oncol Lett. 2019 Oct ;18(4):4253-4261. Epub 2019 Aug 14. PMID: 31579089 Abstract Title: Sulforaphane enhances apoptosis induced bystrain S-PT84 via the TNFα pathway in human colon cancer cells. Abstract: Sulforaphane andinduce apoptosis in several cancer cells. Sulforaphane, a dietary isothiocyanate, is an attractive agent due to its potent anticancer effects. Sulforaphane suppresses the proliferation …
Gene targets of sulforaphane in head and neck squamous cell carcinoma.
PMID: Mol Med Rep. 2019 Dec ;20(6):5335-5344. Epub 2019 Oct 23. PMID: 31661135 Abstract Title: Gene targets of sulforaphane in head and neck squamous cell carcinoma. Abstract: Patients who have undergone curative‑intent therapy for head and neck squamous cell carcinoma (HNSCC) exhibit a high rate of development of second primary tumors (SPTs), which are frequently …
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Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy.
PMID: Metabolism. 2020 Jan ;102:154002. Epub 2019 Nov 9. PMID: 31706979 Abstract Title: Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function. Abstract: BACKGROUND: AMP-activated protein kinase (AMPK), particularly AMPKα2 isoform, plays a critical role in maintaining cardiac homeostasis. It was reported that sulforaphane (SFN) …
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Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders.
PMID: Sci Total Environ. 2020 Mar 10 ;707:135624. Epub 2019 Nov 21. PMID: 31784171 Abstract Title: Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders. Abstract: Neurological disorders represent a great challenge and are the leading cause of death and disability globally. Although numerous complicated mechanisms are involved in the progressions of chronic and …
Protective role of Nrf2 against ischemia reperfusion injury and cardiac allograft vasculopathy.
PMID: Am J Transplant. 2019 Nov 26. Epub 2019 Nov 26. PMID: 31769924 Abstract Title: Protective role of Nrf2 against ischemia reperfusion injury and cardiac allograft vasculopathy. Abstract: Ischemia-reperfusion injury (IRI) and cardiac allograft vasculopathy (CAV) remain unsolved complications post-heart transplant (Tx). The antioxidant transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been …
High levels of apoptosis are induced in the human colon cancer HT-29 cell line by co-administration of sulforaphane and a peptide nucleic acid.
PMID: Nucleic Acid Ther. 2020 Feb 17. Epub 2020 Feb 17. PMID: 32069125 Abstract Title: High Levels of Apoptosis Are Induced in the Human Colon Cancer HT-29 Cell Line by Co-Administration of Sulforaphane and a Peptide Nucleic Acid Targeting miR-15b-5p. Abstract: Sulforaphane (SFN) is one of most important dietary constituents of broccoli () and other …
Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension.
PMID: Am J Physiol Heart Circ Physiol. 2020 Apr 1 ;318(4):H853-H866. Epub 2020 Feb 28. PMID: 32108526 Abstract Title: Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension. Abstract: Right ventricular (RV) dysfunction is the main determinant of mortality in patients with pulmonary arterial hypertension (PAH) and while inflammation is …
Sulforaphane: expected to become a novel anti-tumor compound.
PMID: Oncol Res. 2020 Feb 28. Epub 2020 Feb 28. PMID: 32111265 Abstract Title: Sulforaphane: Expected to Become a Novel Anti-tumor Compound. Abstract: Natural products are becoming increasingly popular in a variety of traditional, complementary and alternative systems due to their potency and slight side effects. Natural compounds have been shown to be effective against …
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