Author Archives: Taylor Mercado

PMID:  Arch Pharm Res. 2020 Mar 10. Epub 2020 Mar 10. PMID: 32152852 Abstract Title:  Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems. Abstract:  Sulforaphane is an isothiocyanate compound that has been derived from cruciferous vegetables. It was shown in numerous studies to be active against …

Continue reading “Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems.”

PMID:  Cancer Prev Res (Phila). 2020 Mar 11. Epub 2020 Mar 11. PMID: 32161072 Abstract Title:  Epigenome, transcriptome and protection by sulforaphane at different stages of UVB-induced skin carcinogenesis. Abstract:  Sulforaphane (SFN), a potent antioxidant and anti-inflammatory agent, has been shown to protect against cancers especially at early stages. However, how SFN affects UVB-mediated epigenome/DNA …

Continue reading “Epigenome, transcriptome and protection by sulforaphane at different stages of UVB-induced skin carcinogenesis.”

PMID:  Toxicol Appl Pharmacol. 2020 Feb 29 ;393:114941. Epub 2020 Feb 29. PMID: 32126212 Abstract Title:  Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells. Abstract:  Incidence of nonalcoholic fatty liver disease is increasing worldwide. Activation of the NLRP3 inflammasome is central to the development of diet-induced …

Continue reading “Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis.”

PMID:  Acta Pharmacol Sin. 2020 Mar 4. Epub 2020 Mar 4. PMID: 32132657 Abstract Title:  PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells. Abstract:  Phenethyl isothiocyanate (PEITC) is an isothiocyanate that largely exists in cruciferous vegetables and exhibits chemopreventive and chemotherapeutic potential against various cancers. However, it is …

Continue reading “Phenethyl isothiocyanate has promising anti-osteosarcoma activity.”

PMID:  Mol Carcinog. 2020 Mar 18. Epub 2020 Mar 18. PMID: 32189414 Abstract Title:  Phenethyl isothiocyanate synergistically induces apoptosis with Gefitinib in non-small cell lung cancer cells via endoplasmic reticulum stress-mediated degradation of Mcl-1. Abstract:  Isothiocyanates (ITCs) are natural compounds abundant in cruciferous vegetables. Numerous studies have shown that ITCs exhibit anticancer activity by affecting …

Continue reading “Phenethyl isothiocyanate synergistically induces apoptosis with Gefitinib in non-small cell lung cancer cells.”

PMID:  Eur J Nutr. 2020 Mar 25. Epub 2020 Mar 25. PMID: 32215717 Abstract Title:  Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma. Abstract:  OBJECTIVE(S): Growing evidence supports that isothiocyanates exert a wide range of bioactivities amongst of which is their capacity to interact with the epigenetic machinery …

Continue reading “Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma.”

PMID:  Neurochem Int. 2020 Mar 18:104728. Epub 2020 Mar 18. PMID: 32199985 Abstract Title:  Sulforaphane Attenuates Apoptosis of Hippocampal Neurons Induced by High Glucose via Regulating Endoplasmic Reticulum. Abstract:  Diabetic encephalopathy (DE) has been defined as one of the major complications of diabetes, characterized by neurochemical and neurodegenerative changes. However, the molecular mechanism of DE …

Continue reading “Sulforaphane attenuates apoptosis of hippocampal neurons induced by high glucose.”

PMID:  Foods. 2020 Feb 24 ;9(2). Epub 2020 Feb 24. PMID: 32102416 Abstract Title:  New Evidences of Antibacterial Effects of Cranberry Against Periodontal Pathogens. Abstract:  The worrying rise in antibiotic resistances emphasizes the need to seek new approaches for treating and preventing periodontal diseases. The purpose of this study was to evaluate the antibacterial and …

Continue reading “New evidences of antibacterial effects of cranberry against periodontal pathogens.”

PMID:  BMC Complement Med Ther. 2020 Mar 6 ;20(1):71. Epub 2020 Mar 6. PMID: 32143616 Abstract Title:  Cranberry extract initiates intrinsic apoptosis in HL-60 cells by increasing BAD activity through inhibition of AKT phosphorylation. Abstract:  BACKGROUND: Cranberry has been studied as a potential anticancer agent as it is capable of inducing apoptosis within cancer cells. …

Continue reading “Cranberry extract initiates intrinsic apoptosis in HL-60 cells by increasing BAD activity through inhibition of AKT phosphorylation.”

PMID:  Adv Urol. 2020 ;2020:6325490. Epub 2020 Jan 13. PMID: 32215007 Abstract Title:  Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed, Isoflavonoids, and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Pilot Study. Abstract:  Phytotherapy for lower urinary tract symptoms (LUTSs) due to benign prostate hyperplasia (BPH) is progressively demanded by patients …

Continue reading “Oral combination of pumpkin seed extract, soy germ isoflavonoids, and cranberry could be beneficial for benign prostate hyperplasia patients.”