Taylor Mercado

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation.

PMID: Pharmacol Res. 2020 Mar 7 ;155:104746. Epub 2020 Mar 7. PMID: 32156650 Abstract Title: Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice. Abstract: Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. …

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Relationship between ginsenoside Rg3 and metabolic syndrome.

PMID: Front Pharmacol. 2020 ;11:130. Epub 2020 Feb 25. PMID: 32161549 Abstract Title: Relationship Between Ginsenoside Rg3 and Metabolic Syndrome. Abstract: Metabolic syndrome is an important public health issue and is associated with a more affluent lifestyle. Many studies of metabolic syndrome have been reported, but its pathogenesis remains unclear and there is no effective …

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Effect of patchouli alcohol on macrophage mediated Helicobacter pylori digestion based on intracellular urease inhibition.

PMID: Phytomedicine. 2019 Dec ;65:153097. Epub 2019 Sep 25. PMID: 31568921 Abstract Title: Effect of patchouli alcohol on macrophage mediated Helicobacter pylori digestion based on intracellular urease inhibition. Abstract: BACKGROUND: Helicobacter pylori infects almost half of the world population and is listed as a type I carcinoma factor since 1994. Pogostemon cablin (Blanco) Benth. (Labiatae) …

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Patchouli alcohol activates PXR and suppresses the NF-κB-mediated intestinal inflammatory.

PMID: J Ethnopharmacol. 2020 Feb 10 ;248:112302. Epub 2019 Oct 12. PMID: 31614203 Abstract Title: Patchouli alcohol activates PXR and suppresses the NF-κB-mediated intestinal inflammatory. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: The pregnane-X-receptor (PXR) is involved in inflammatory bowel disease (IBD). Patchouli alcohol (PA) has anti-inflammatory effects; however, the effect of PA on IBD pathogenesis remains largely unknown.AIM …

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Protective effect of patchouli alcohol against high-fat diet Induced hepatic steatosis.

PMID: Front Pharmacol. 2019 ;10:1134. Epub 2019 Oct 1. PMID: 31632274 Abstract Title: Protective Effect of Patchouli Alcohol Against High-Fat Diet Induced Hepatic Steatosis by Alleviating Endoplasmic Reticulum Stress and Regulating VLDL Metabolism in Rats. Abstract: Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic hepatic disorder worldwide. The earliest stage of NAFLD …

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Patchouli alcohol possesses health benefit effect through inhibiting adipogenesis and fat tissue development.

PMID: J Med Food. 2020 Mar ;23(3):326-334. Epub 2019 Nov 21. PMID: 31750759 Abstract Title: Patchouli Alcohol, a Compound from, Inhibits Obesity. Abstract: Obesity predisposes people to a variety of chronic metabolic diseases. Identification of natural factors that prevent the development of obesity is likely to be the most successful means of ameliorating the current …

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The results showed that patchouli alcohol significantly inhibited different influenza virus strain multiplication in vitro.

PMID: Virol J. 2019 12 23 ;16(1):163. Epub 2019 Dec 23. PMID: 31870450 Abstract Title: Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways. Abstract: BACKGROUND: Patchouli alcohol (PA) is a tricyclic sesquiterpene extracted from Pogostemonis Herba, which is a traditional Chinese medicine used for therapy of …

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Patchouli oil attenuates high fat diet-induced non-alcoholic hepatic steatosis.

PMID: Planta Med. 2020 Mar ;86(4):255-266. Epub 2020 Jan 23. PMID: 31975362 Abstract Title: Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis. Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Nevertheless, no first-line therapy exists. Hepatic steatosis is the earliest stage of NAFLD, which is characterized …

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Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis.

PMID: Biomed Pharmacother. 2020 Apr ;124:109883. Epub 2020 Jan 28. PMID: 32004938 Abstract Title: Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota. Abstract: Intestinal mucositis causes great suffering to cancer patients who undergo chemotherapy and radiotherapy. Owing to the uncertain side effects of anticancer drugs to attenuate patients' intestinal mucositis, …

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Cucurbitacin D overcomes gefitinib resistance in gefitinib-resistant NSCLC cells.

PMID: Front Oncol. 2020 ;10:62. Epub 2020 Feb 18. PMID: 32133284 Abstract Title: Cucurbitacin D Overcomes Gefitinib Resistance by Blocking EGF Binding to EGFR and Inducing Cell Death in NSCLCs. Abstract: In this study, the mechanism of the anticancer effect through which cucurbitacin D (CuD) can overcome gefitinib resistance in NSCLC was investigated. Cell viability …

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