Taylor Mercado

Radix astragalus isoflavones exhibit osteogenic activity.

PMID: Phytother Res. 2018 Jan ;32(1):115-124. Epub 2017 Oct 18. PMID: 29044703 Abstract Title: A comparative study on the effect of promoting the osteogenic function of osteoblasts using isoflavones from Radix Astragalus. Abstract: Radix Astragalus has been shown to exert beneficial effects regarding the prevention postmenopausal osteoporosis. However, its mechanism of action remains to be …

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A review of the antioxidant effects of radix astragali and its role in protecting tissues from injury and disease.

PMID: Curr Drug Targets. 2016 ;17(12):1331-40. PMID: 26343107 Abstract Title: The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease. Abstract: Oxidative stress plays a key role in the pathogenesis of various diseases. Antioxidants protect the cells and tissues from oxidative stress by scavenging free radicals and …

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Astragalus polysaccharide increases cellular autophagy in vitro.

PMID: Int J Biol Macromol. 2020 Feb 26 ;153:349-356. Epub 2020 Feb 26. PMID: 32112840 Abstract Title: Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro. Abstract: Astragalus polysaccharide (APS) is a bioactive macromolecule, which has been used to alleviate the development of Parkinson's disease (PD), while its …

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Bergamot is a promising alternative therapeutic option in dyslipidemia.

PMID: Crit Rev Food Sci Nutr. 2019 Oct 31:1-11. Epub 2019 Oct 31. PMID: 31670973 Abstract Title: Effect of bergamot on lipid profile in humans: A systematic review. Abstract: Dyslipidemia is a well-established modifiable cardiovascular risk. Although statins can reduce LDLc by 50-60%, less than 20% of patients with high risk of CVD achieve LDL …

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Grape pomace polyphenols and pectin reduce trimethylamine-n-oxide serum levels.

PMID: Front Pharmacol. 2019 ;10:575. Epub 2019 May 21. PMID: 31164827 Abstract Title: Effect of Grape Pomace Polyphenols With or Without Pectin on TMAO Serum Levels Assessed by LC/MS-Based Assay: A Preliminary Clinical Study on Overweight/Obese Subjects. Abstract: Growing evidence suggests that trimethylamine N-oxide (TMAO) is recognized as a biomarker of increased cardiovascular risk. So …

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Grape pomace phenolic extract reduces trimethylamine-n-oxide levels in humans.

PMID: Nutrients. 2019 Jan 10 ;11(1). Epub 2019 Jan 10. PMID: 30634687 Abstract Title: Effects of Grape Pomace Polyphenolic Extract (Taurisolo) in Reducing TMAO Serum Levels in Humans: Preliminary Results from a Randomized, Placebo-Controlled, Cross-Over Study. Abstract: Trimethylamine N-oxide (TMAO) is considered a novel risk factor for cardiovascular diseases. Several studies demonstrated that polyphenols are …

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Fermentable carbohydrates and polyphenols inhibit trimethylamine production in the colon.

PMID: Food Funct. 2018 Dec 13 ;9(12):6470-6483. PMID: 30465688 Abstract Title: An in vitro exploratory study of dietary strategies based on polyphenol-rich beverages, fruit juices and oils to control trimethylamine production in the colon. Abstract: Trimethylamine-N-oxide (TMAO) has been described as a new biomarker of cardiovascular disease (CVD), derived from gut microbial biotransformation of dietary …

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Resveratrol reduces trimethylamine-n-oxide synthesis and increases hepatic bile acid synthesis.

PMID: mBio. 2016 Apr 5 ;7(2):e02210-15. Epub 2016 Apr 5. PMID: 27048804 Abstract Title: Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota. Abstract: UNLABELLED: The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phytoalexin with anti-AS …

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Exercise and calorie restriction appears to be effective in reducing trimethylamine-n-oxide in obese adults.

PMID: Nutrients. 2019 Jan 16 ;11(1). Epub 2019 Jan 16. PMID: 30654453 Abstract Title: Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults. Abstract: Accumulating evidence linking trimethylamine N-oxide (TMAO) to cardiovascular disease (CVD) risk has prompted interest in developing therapeutic strategies to reduce its production. We compared two lifestyle intervention approaches: hypocaloric …

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This study demonstrated that CKD patients had increased plasma TMAO levels due to contributions from both impaired renal functions and dysbiosis of the gut microbiota.

PMID: Sci Rep. 2017 05 3 ;7(1):1445. Epub 2017 May 3. PMID: 28469156 Abstract Title: Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients. Abstract: Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases (CVDs). The present study aimed to investigate the gut microbiota …

Continue reading “This study demonstrated that CKD patients had increased plasma TMAO levels due to contributions from both impaired renal functions and dysbiosis of the gut microbiota.”