PMID: Fitoterapia. 2020 Mar 14:104553. Epub 2020 Mar 14. PMID: 32184097 Abstract Title: Cannabidiol exerts protective effects in an in vitro model of Parkinson's disease activating AKT/mTOR pathway. Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the degeneration of the nigrostriatal dopaminergic pathway with loss of substantia nigra pars compacta neurons and dopamine …
Author Archives: Taylor Mercado
Vitamin C ameliorated cardiac autonomic neuropathy in type 2 diabetic rats.
PMID: World J Diabetes. 2020 Mar 15 ;11(3):52-65. PMID: 32180894 Abstract Title: Vitamin C ameliorated cardiac autonomic neuropathy in type 2 diabetic rats. Abstract: BACKGROUND: Vitamin C (VC) is a common antioxidant with cell protection potentials. However, its possible protective effect on cardiac autonomic nerves from diabetic induced insults is yet to be explored.AIM: To …
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Vitamin C restricts the emergence of acquired resistance to EGFR-targeted therapies in colorectal cancer.
PMID: Cancers (Basel). 2020 Mar 14 ;12(3). Epub 2020 Mar 14. PMID: 32183295 Abstract Title: Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer. Abstract: The long-term efficacy of the Epidermal Growth Factor Receptor (EGFR)-targeted antibody cetuximab in advanced colorectal cancer (CRC) patients is limited by the emergence of drug-resistant …
Dietary melatonin supplementation may have beneficial effects in the management of metabolic syndrome.
PMID: Endocr Metab Immune Disord Drug Targets. 2019 Oct 9. Epub 2019 Oct 9. PMID: 32138638 Abstract Title: Dietary melatonin protects against behavioural, metabolic, oxidative, and organ morphological changes in mice that are fed high-fat, high-sugar diet. Abstract: BACKGROUND: Metabolic syndrome is a complex pattern of disorders which occur jointly and is associated with increased …
Melatonin and oxidative stress in melasma – an unexplored territory; a prospective study.
PMID: Int J Dermatol. 2020 Mar 5. Epub 2020 Mar 5. PMID: 32141063 Abstract Title: Melatonin and oxidative stress in melasma – an unexplored territory; a prospective study. Abstract: BACKGROUND: Melasma, an acquired disorder of hyperpigmentation, is the most common pigmentary disorder in India. Many factors are implicated in the pathogenesis, and recently the role …
Melatonin for the treatment of sepsis: the scientific rationale
PMID: J Thorac Dis. 2020 Feb ;12(Suppl 1):S54-S65. PMID: 32148926 Abstract Title: Melatonin for the treatment of sepsis: the scientific rationale. Abstract: Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO), and despite decades of research, novel initiatives are drastically needed. According to the current literature, oxidative imbalance and mitochondrial …
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Melatonin mitigates chilling-induced oxidative stress and photosynthesis inhibition in tomato plants.
PMID: Antioxidants (Basel). 2020 Mar 6 ;9(3). Epub 2020 Mar 6. PMID: 32155702 Abstract Title: Melatonin Mitigates Chilling-Induced Oxidative Stress and Photosynthesis Inhibition in Tomato Plants. Abstract: Melatonin has been demonstrated to play a variety of roles in plants. Of particular importance is its role as a potent antioxidative agent. In the present study, we …
Melatonin triggers metabolic and gene expression changes leading to improved quality traits of two sweet cherry cultivars during cold storage.
PMID: Food Chem. 2020 Feb 5 ;319:126360. Epub 2020 Feb 5. PMID: 32151896 Abstract Title: Melatonin triggers metabolic and gene expression changes leading to improved quality traits of two sweet cherry cultivars during cold storage. Abstract: Sweet cherry is a valuable non-climacteric fruit with elevated phytonutrients, whose fruit quality attributes are prone to rapid deterioration …
The results indicate that cannabinoids reduce the tumour growth in animal models of glioblastoma multiforme.
PMID: Eur J Pharmacol. 2020 Mar 4 ;876:173055. Epub 2020 Mar 4. PMID: 32145324 Abstract Title: The effects of cannabinoids on glioblastoma growth: A systematic review with meta-analysis of animal model studies. Abstract: Glioblastoma multiforme (GBM) is the most frequent and aggressive malignant brain tumour, with a poor prognosis despite available surgical and radio-chemotherapy, rising …
Melatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseases.
PMID: Histol Histopathol. 2020 Mar 10:18212. Epub 2020 Mar 10. PMID: 32154907 Abstract Title: Melatonin and cannabinoids: mitochondrial-targeted molecules that may reduce inflammaging in neurodegenerative diseases. Abstract: Generally, the development and progression of neurodegenerative diseases are associated with advancing age, so they are usually diagnosed in late adulthood. A primary mechanism underlying the onset of …
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