PMID: J Biochem Mol Toxicol. 2020 Jan ;34(1):e22416. Epub 2019 Nov 12. PMID: 31714633 Abstract Title: Neuroprotective effects of mitochondria-targeted curcumin against rotenone-induced oxidative damage in cerebellum of mice. Abstract: The present study investigated the protective effect of curcumin and mitochondrial-targeted curcumin (MTC) in rotenone-induced cerebellar toxicity in mice. Treatment of rotenone in mice significantly …
Author Archives: Taylor Mercado
The results of the current study reveal the neuroprotective competency of piperine against Huntington disease like symptoms.
PMID: Nutr Neurosci. 2020 Feb 25:1-10. Epub 2020 Feb 25. PMID: 32093571 Abstract Title: Piperine mitigates behavioral impairments and provides neuroprotection against 3-nitropropinoic acid-induced Huntington disease-like symptoms. Abstract: Piperine (PIP) is a powerful anti-oxidant and anti-inflammatory alkaloid which has been widely used in the treatment of various pathological conditions. However, few studies have clearly discussed …
Curcumin and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model.
PMID: Front Bioeng Biotechnol. 2020 ;8:50. Epub 2020 Feb 11. PMID: 32117930 Abstract Title: Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model. Abstract: Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates a …
Protection of curcumin against streptozocin-induced pancreatic cell destruction in T2D rats.
PMID: Planta Med. 2020 Jan ;86(2):113-120. Epub 2019 Dec 4. PMID: 31801161 Abstract Title: Protection of Curcumin against Streptozocin-Induced Pancreatic Cell Destruction in T2D Rats. Abstract: As a kind of traditional Chinese medicine extract, curcumin has been proven to be effective in inhibiting inflammation and apoptosis in pancreatic isletcells in the streptozotocin-induced diabetes mellitus rat …
Curcumin inhibits the proliferation, migration, invasion, and apoptosis of diffuse large B-cell lymphoma cell line.
PMID: Yonsei Med J. 2020 Jan ;61(1):20-29. PMID: 31887796 Abstract Title: Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis. Abstract: PURPOSE: Curcumin exerts its anti-cancer effects, partly by targeting special microRNAs, in human cancers. MiR-21 is a key oncomir in carcinogenesis of multiple human …
Encapsulated curcumin enhances intestinal absorption and improves hepatic damage in alcoholic liver disease-induced rats.
PMID: Prev Nutr Food Sci. 2019 Dec ;24(4):410-417. Epub 2019 Dec 31. PMID: 31915636 Abstract Title: Encapsulated Curcumin Enhances Intestinal Absorption and Improves Hepatic Damage in Alcoholic Liver Disease-Induced Rats. Abstract: Encapsulated curcumin (ENCC) was prepared from a commercial curcuminoids complex and was evaluated for its intestinal permeability and hepatoprotective effects. Intestinal permeability was evaluated …
curcumin supplementation can improve serum levels of inflammatory cytokines in subjects with NAFLD.
PMID: Complement Ther Med. 2020 Mar ;49:102322. Epub 2020 Jan 21. PMID: 32147075 Abstract Title: Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial. Abstract: BACKGROUND: Nonalcoholic fatty liver diseases (NAFLD) is a highly prevalent disease that is closely associated with several cardiometabolic complications. The potential anti-inflammatory …
Bisdemethoxycurcumin attenuates cisplatin-induced renal injury through anti-apoptosis, anti-oxidant and anti-inflammatory.
PMID: Eur J Pharmacol. 2020 May 5 ;874:173026. Epub 2020 Feb 20. PMID: 32088177 Abstract Title: Bisdemethoxycurcumin attenuates cisplatin-induced renal injury through anti-apoptosis, anti-oxidant and anti-inflammatory. Abstract: Cisplatin is a widely used chemotherapy drug that is first-line therapy for a variety of tumors. Unfortunately, its adverse effects on various normal tissues and organs, especially nephrotoxicity, …
The combination of curcuminoids could be used as a novel target for the treatment of osteosarcoma.
PMID: BMC Complement Med Ther. 2020 Mar 3 ;20(1):68. Epub 2020 Mar 3. PMID: 32126993 Abstract Title: Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and -independent apoptosis via Smad or Akt signaling pathways in HOS cells. Abstract: BACKGROUND: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents and has also been associated …
Bisdemethoxycurcumin inhibits hepatocellular carcinoma proliferation.
PMID: Drug Des Devel Ther. 2020 ;14:993-1001. Epub 2020 Mar 5. PMID: 32184568 Abstract Title: Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination. Abstract: Background: Bisdemethoxycurcumin (BDMC), a stable bioactive ingredient in curcuminoids, is associated with various antitumor functions, such as proliferation inhibition, metastasis suppression and apoptosis induction, in many cancer types. …
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