Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation.

PMID:  Biomed Pharmacother. 2020 Feb 26 ;126:110041. Epub 2020 Feb 26. PMID: 32113053 Abstract Title:  Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats. Abstract:  This study is to explore the neuroprotective effects and involved glial scar of saffron (Crocus sativus L.) on the late …

Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis.

PMID:  Int J Infect Dis. 2020 Mar 12. Epub 2020 Mar 12. PMID: 32173574 Abstract Title:  Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. Abstract:  BACKGROUND: An outbreak of Novel Coronavirus (COVID -19) in Wuhan, China, the epidemic is more widespread than initially estimated, with cases now confirmed …

Ferulic acid alleviates atopic dermatitis-like symptoms in mice via its potent anti-inflammatory effect.

PMID:  Immunopharmacol Immunotoxicol. 2020 Apr ;42(2):156-164. Epub 2020 Mar 3. PMID: 32122212 Abstract Title:  Ferulic acid alleviates atopic dermatitis-like symptoms in mice via its potent anti-inflammatory effect. Abstract:  Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interactions between multiple genetic and environmental factors. The pathogenesis of AD is still not completely …

These findings suggest that ferulic acid may protect H9c2 cells against ischemia/reperfusion injury.

PMID:  Front Pharmacol. 2020 ;11:103. Epub 2020 Feb 25. PMID: 32161543 Abstract Title:  Ferulic Acid Attenuates Hypoxia/Reoxygenation Injury by Suppressing Mitophagy Through the PINK1/Parkin Signaling Pathway in H9c2 Cells. Abstract:  Ferulic acid protects against cardiac injury by scavenging free radicals. However, the role of mitophagy in ferulic acid-induced cardioprotection remains obscure. In the present study, …

Gastrodin can inhibit H2O2-induced ferroptosis through its antioxidative effect in C6 cells.

PMID:  Biol Pharm Bull. 2020 ;43(3):480-487. PMID: 32115506 Abstract Title:  Gastrodin Inhibits HO-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. Abstract:  Ferroptosis is a form of necrosis caused by iron-induced accumulation of lipid hydroperoxide, involving several molecular events, and has been implicated in Parkinson's disease. Gastrodin is a component of Gastrodia …

Gastrodin improves preeclampsia-induced cell apoptosis by regulation of TLR4/NF-κB.

PMID:  Food Sci Nutr. 2020 Feb ;8(2):820-829. Epub 2020 Jan 10. PMID: 32148791 Abstract Title:  Gastrodin improves preeclampsia-induced cell apoptosis by regulation of TLR4/NF-κB in rats. Abstract:  To explain gastrodin improved cell apoptosis induced by preeclampsia in vivo and in vitro study. The PE and normal rats were injected with normal saline (Model), low-dose gastrodin …

A history of smoking may lead to a more severe coronavirus infection.

PMID:  Chin Med J (Engl). 2020 Feb 28. Epub 2020 Feb 28. PMID: 32118640 Abstract Title:  Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Abstract:  BACKGROUND: Since early December 2019, the 2019 novel coronavirus disease (COVID-19) has caused pneumonia epidemic in Wuhan, Hubei province of China. This study …

Fucoidan ameliorates oxidative stress, inflammation, DNA damage, and hepatorenal injuries in diabetic rats.

PMID:  Oxid Med Cell Longev. 2020 ;2020:9316751. Epub 2020 Feb 10. PMID: 32104544 Abstract Title:  Fucoidan Ameliorates Oxidative Stress, Inflammation, DNA Damage, and Hepatorenal Injuries in Diabetic Rats Intoxicated with Aflatoxin B. Abstract:  The current study was carried out to evaluate the ameliorative effect of fucoidan against aflatoxicosis-induced hepatorenal toxicity in streptozotocin-induced diabetic rats. Sixty-four …

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study.

PMID:  Mar Drugs. 2020 Feb 28 ;18(3). Epub 2020 Feb 28. PMID: 32121066 Abstract Title:  Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study. Abstract:  Fucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment …

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