Photobiomodulation of inflammatory-cytokine-related effects in a 3-D culture model with gingival fibroblasts.

PMID:  Lasers Med Sci. 2020 Feb 7. Epub 2020 Feb 7. PMID: 32030556 Abstract Title:  Photobiomodulation of inflammatory-cytokine-related effects in a 3-D culture model with gingival fibroblasts. Abstract:  The aim of this study was to assess the effects of IL-6 and IL-8 cytokines on human gingival fibroblasts (HGF) cultured in a 3-D model and the …

Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients.

PMID:  J Family Med Prim Care. 2020 Jan ;9(1):69-71. Epub 2020 Jan 28. PMID: 32110567 Abstract Title:  Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients. Abstract:  Introduction: Incidence of diabetes mellitus has increased over the past few years, mainly due to our eating habits and physical inactivity. This also includes the …

Naringenin ameliorates carbon tetrachloride-induced hepatic damage.

PMID:  J Med Food. 2020 Mar 3. Epub 2020 Mar 3. PMID: 32125927 Abstract Title:  Naringenin Ameliorate Carbon Tetrachloride-Induced Hepatic Damage Through Inhibition of Endoplasmic Reticulum Stress and Autophagy in Rats. Abstract:  Hepatic fibrosis emerges upon exposure of liver to various chemicals and if not treated, it develops various diseases such as cirrhosis and cancer. …

Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin.

PMID:  Basic Clin Pharmacol Toxicol. 2020 Mar 16. Epub 2020 Mar 16. PMID: 32180335 Abstract Title:  Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin. Abstract:  Naringenin possesses many pharmacological effects and may modulate metformin disposition. The purpose of this study was to evaluate …

Naringenin inhibited Pseudomonas aeruginosa quorum sensing.

n/a PMID:  Front Mol Biosci. 2020 ;7:25. Epub 2020 Feb 28. PMID: 32181260 Abstract Title:  Naringenin Inhibition of theQuorum Sensing Response Is Based on Its Time-Dependent Competition With-(3-Oxo-dodecanoyl)-L-homoserine Lactone for LasR Binding. Abstract:  Bacterial quorum sensing (QS) is a cell-to-cell communication system that governs the expression of a large set of genes involved in bacterial-host …

Naringin may have a therapeutic effect on endothelial injury-related disorders.

PMID:  Biosci Rep. 2020 Mar 27 ;40(3). PMID: 32091090 Abstract Title:  Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway. Abstract:  Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, …

Naringin provides neuroprotection in CCL2-induced cognition impairment by attenuating neuronal apoptosis in the hippocampus.

PMID:  Behav Brain Funct. 2020 Feb 27 ;16(1):4. Epub 2020 Feb 27. PMID: 32103758 Abstract Title:  Naringin provides neuroprotection in CCL2-induced cognition impairment by attenuating neuronal apoptosis in the hippocampus. Abstract:  BACKGROUND: Chemokine C-C motif ligand 2 (CCL2) is one of the most widely recognised proinflammatory chemokines in cognitive disorders. Currently, CCL2-targeting drugs are extremely …

Colon targeting of naringin for enhanced cytoprotection against indomethacin-induced colitis.

PMID:  Drug Des Devel Ther. 2020 ;14:677-696. Epub 2020 Feb 19. PMID: 32109993 Abstract Title:  Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits. Abstract:  Background: Naringin is a promising anti-inflammatory drug against various disorders including ulcerative colitis. However, its oral bioavailability is low (8%) possibly due to cleavage at the upper …

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