Modulation of allicin-free garlic on gut microbiome

PMID:  Molecules. 2020 Feb 5 ;25(3). Epub 2020 Feb 5. PMID: 32033507 Abstract Title:  Modulation of Allicin-Free Garlic on Gut Microbiome. Abstract:  The allicin diallyldisulfid–oxide, a major garlic organosulfur compound (OSC) in crushed garlic (L.), possesses antibacterial effects, and influences gut bacteria. In this study, we made allicin-free garlic (AFG) extract and investigated its effects …

Allicin modifies the composition and function of the gut microbiota in alcoholic hepatic steatosis mice.

PMID:  J Agric Food Chem. 2020 Mar 11 ;68(10):3088-3098. Epub 2020 Feb 27. PMID: 32050766 Abstract Title:  Allicin Modifies the Composition and Function of the Gut Microbiota in Alcoholic Hepatic Steatosis Mice. Abstract:  The intestinal microbiome plays an important role in the pathogenesis of liver diseases. Alcohol intake induces gut microbiota dysbiosis and alters its …

Allicin can be used as an adjuvant therapy with TMZ to improve the prognosis of patients.

PMID:  Neuromolecular Med. 2020 Feb 21. Epub 2020 Feb 21. PMID: 32086739 Abstract Title:  Overexpression miR-486-3p Promoted by Allicin Enhances Temozolomide Sensitivity in Glioblastoma Via Targeting MGMT. Abstract:  Glioblastoma is the most common primary tumor of the central nervous system that develops chemotherapy resistance. Previous studies showed that Allicin could inhibit multiple cancer cells including …

Antimicrobial activity of garlic derivatives on common causative microorganisms of the external ear canal and chronic middle ear infections.

PMID:  Turk Arch Otorhinolaryngol. 2019 Dec ;57(4):161-165. Epub 2019 Dec 1. PMID: 32128511 Abstract Title:  Antimicrobial Activity of Garlic Derivatives on Common Causative Microorganisms of the External Ear Canal and Chronic Middle Ear Infections. Abstract:  Objective: Today, antibiotic resistance is increasing and evolving into an important health problem. Therefore, it is important to research on …

Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathway.

PMID:  Eur J Pharmacol. 2020 Mar 2:173052. Epub 2020 Mar 2. PMID: 32135124 Abstract Title:  Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathway. Abstract:  As diabetic macroangiopathy is becoming increasingly prevalent, it is urgent to explore preventive and therapeutic drugs and study the mechanism. Diabetic mice were induced by intraperitoneal injection …

Improved cardioprotective effects of hesperidin solid lipid nanoparticles prepared by supercritical antisolvent technology.

PMID:  Colloids Surf B Biointerfaces. 2019 Nov 12:110628. Epub 2019 Nov 12. PMID: 31753617 Abstract Title:  Improved cardioprotective effects of hesperidin solid lipid nanoparticles prepared by supercritical antisolvent technology. Abstract:  Doxorubicin (DOX) is commonly used for the treatment of many types of cancers but its cardiotoxicity, owing to free radical formation, limits its clinical use. …

Hesperidin could be considered as a dietary supplement to manage type 2 diabetes and to suppress oxidative stress mediated diabetic pathophysiology.

PMID:  Cell Biochem Funct. 2020 Jan 11. Epub 2020 Jan 11. PMID: 31926116 Abstract Title:  In vitro evaluation of antidiabetic potential of hesperidin and its aglycone hesperetin under oxidative stress in skeletal muscle cell line. Abstract:  The present study investigates the in vitro antidiabetic and antioxidant potential of hesperidin and hesperetin under oxidative stress induced …

A review of hesperidin: A therapeutic agent for obesity.

PMID:  Drug Des Devel Ther. 2019 ;13:3855-3866. Epub 2019 Nov 12. PMID: 32009777 Abstract Title:  Hesperidin: A Therapeutic Agent For Obesity. Abstract:  Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various cancers. Hesperidin, a flavanone glycoside, …

Exosomes derived from epigallocatechin gallate-treated cardiomyocytes attenuated acute myocardial infarction.

PMID:  Front Pharmacol. 2020 ;11:126. Epub 2020 Feb 26. PMID: 32161548 Abstract Title:  Exosomes Derived From Epigallocatechin Gallate-Treated Cardiomyocytes Attenuated Acute Myocardial Infarction by Modulating MicroRNA-30a. Abstract:  Background: Ischemia-derived exosomes can restrict excessive autophagy by transferring microRNA-30a (miR30a) to cells. Reports have confirmed that epigallocatechin gallate (EGCG) alleviates acute myocardial infarction (AMI) by regulating autophagy; …

Inhibitory potential of EGCG on Streptococcus mutans biofilm: A new approach to prevent Cariogenesis.

PMID:  Microb Pathog. 2020 Mar 10:104129. Epub 2020 Mar 10. PMID: 32169491 Abstract Title:  Inhibitory potential of EGCG on Streptococcus mutans biofilm: A new approach to prevent Cariogenesis. Abstract:  Dental caries is a common cause for tooth loss and Streptococcus mutans is identified as the etiologic pathogen. This study evaluates the inhibitory potential of Epigallocatechin …

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