PMID: Cell Stress Chaperones. 2020 Mar 6. Epub 2020 Mar 6. PMID: 32144684 Abstract Title: Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor. Abstract: Activator protein-1 (AP-1) plays a decisive role in cell proliferation, apoptosis, and inflammation under hypoxia; thus, AP-1 subunits or dimers could be …
Author Archives: Taylor Mercado
miR-497 plays a key role in Tanshinone IIA-attenuated proliferation in OCI-AML3 cells via the MAPK/ERK1/2 pathway.
PMID: Cytotechnology. 2020 Mar 11. Epub 2020 Mar 11. PMID: 32162175 Abstract Title: miR-497 plays a key role in Tanshinone IIA-attenuated proliferation in OCI-AML3 cells via the MAPK/ERK1/2 pathway. Abstract: Acute myelod leukemia (AML), as a uncontrolled proliferation of cells, was arrested differentiation of progenitor cells. The present study aimed to explore Tanshinone IIA (TIIA) …
The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction.
PMID: Complement Ther Med. 2020 Mar ;49:102358. Epub 2020 Feb 26. PMID: 32147056 Abstract Title: The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review. Abstract: OBJECTS: Cardiovascular disease (CVD) is one of the leading causes of death worldwide. CVD is associated with increased levels of reactive oxygen …
Effects of ayahuasca on mental health and quality of life in naïve users.
PMID: Sci Rep. 2020 Mar 5 ;10(1):4075. Epub 2020 Mar 5. PMID: 32139811 Abstract Title: Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination. Abstract: Ayahuasca is a hallucinogenic decoction used as a traditional medicine in several Amazonian regions. The ritualistic use of ayahuasca has …
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These results suggest that gomisin A protects the liver from injury after administration of acetaminophen through the suppression of lipid peroxidation.
PMID: Biochem Pharmacol. 1993 Sep 14 ;46(6):1081-5. PMID: 8216352 Abstract Title: Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats. Abstract: The preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats was examined by histological and biochemical analysis. Acetaminophen at a …
Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.
PMID: Arch Pharm Res. 2010 May ;33(5):697-701. Epub 2010 May 29. PMID: 20512467 Abstract Title: Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora. Abstract: This study investigated the 70% aqueous acetone extract of the fruits of Schisandra rubriflora which led to the isolation of eight lignans, including a new isolate, rubrisandrin C (1), …
Continue reading “Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora.”
Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury.
PMID: Int J Mol Med. 2013 Apr ;31(4):888-98. Epub 2013 Jan 31. PMID: 23381504 Abstract Title: Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury. Abstract: The aim of the present study was to investigate the protective effects of gomisin A, a lignan compound isolated from Schisandra chinensis, against …
Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities.
PMID: J Asian Nat Prod Res. 2011 May ;13(5):393-9. PMID: 21534036 Abstract Title: Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities. Abstract: Two new dibenzocyclooctadiene lignans, rubrilignans A and B (1, 2), together with 17 known ones, were isolated from the fruits of Schisandra rubriflora. The structures of 1 and 2 …
Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia.
PMID: Food Chem Toxicol. 2014 Jan ;63:119-27. Epub 2013 Nov 7. PMID: 24211520 Abstract Title: Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway. Abstract: Gomisin A, one of the major dibenzocyclooctadiene lignans isolated from Schisandra chinensis Baill., has proved to possess a variety of pharmacological effects. The aim of …
Schisandrol B protects against cholestatic liver injury through pregnane X receptors.
PMID: Br J Pharmacol. 2017 04 ;174(8):672-688. Epub 2017 Mar 16. PMID: 28128437 Abstract Title: Schisandrol B protects against cholestatic liver injury through pregnane X receptors. Abstract: BACKGROUND AND PURPOSE: Currently, ursodeoxycholic acid and obeticholic acid are the only two FDA-approved drugs for cholestatic liver diseases. Thus, new therapeutic approaches need to be developed. Here …
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