PMID: Psychopharmacology (Berl). 2020 Feb 22. Epub 2020 Feb 22. PMID: 32088834 Abstract Title: Chrysin attenuates traumatic brain injury-induced recognition memory decline, and anxiety/depression-like behaviors in rats: Insights into underlying mechanisms. Abstract: RATIONALE: Cortical and hippocampal neuronal apoptosis and neuroinflammation are associated with behavioral deficits following traumatic brain injury (TBI).OBJECTIVES: The present study was designed …
Author Archives: Taylor Mercado
The present study shows that chrysin can be used to treat pancreatic diseases.
PMID: Ann Ital Chir. 2020 Jan 6 ;9. Epub 2020 Jan 6. PMID: 32129177 Abstract Title: The effects of chrysin in an experimental model of acute pancreatitis. Abstract: PURPOSE: This experimental study was conducted to evaluate the possible effects of orally administered chrysin on acute pancreatitis.MATERIAL AND METHOD: Twenty four rats were procured. The animals …
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Alpha-lipoic acid prevents the ionizing radiation-induced epithelial-mesenchymal transition and enhances the radiosensitivity in breast cancer cells.
PMID: Eur J Pharmacol. 2020 Mar 15 ;871:172938. Epub 2020 Jan 17. PMID: 31958458 Abstract Title: α-Lipoic acid prevents the ionizing radiation-induced epithelial-mesenchymal transition and enhances the radiosensitivity in breast cancer cells. Abstract: Radiotherapy is routinely used in the treatment of breast cancer. However, its efficiency is often limited by the development of radioresistance and …
Alpha-linolenic acid protects against lipopolysaccharide-induced acute lung injury through anti-inflammatory and anti-oxidative pathways.
PMID: Microb Pathog. 2020 Feb 18 ;142:104077. Epub 2020 Feb 18. PMID: 32084579 Abstract Title: Alpha-linolenic acid protects against lipopolysaccharide-induced acute lung injury through anti-inflammatory and anti-oxidative pathways. Abstract: Alpha-linolenic acid (ALA), an important component of polyunsaturated fatty acids (PUFAs), possesses potent anti-inflammatory properties. To date, the effects of ALA on acute lung injury (ALI) …
Amelioration of cyclosporine-induced testicular toxicity by carvedilol and/or alpha-lipoic acid.
PMID: Clin Exp Pharmacol Physiol. 2020 Feb 13. Epub 2020 Feb 13. PMID: 32052493 Abstract Title: Amelioration of cyclosporine-induced testicular toxicity by carvedilol and/or alpha-lipoic acid: Role of TGF-β1, the proinflammatory cytokines, Nrf2/HO-1 pathway and apoptosis. Abstract: Cyclosporine is an immunosuppressive agent that is used to prevent organ rejection after organ transplantation. Due to the widespread …
Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.
PMID: Oncogene. 2020 Feb 14. Epub 2020 Feb 14. PMID: 32060422 Abstract Title: Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines. Abstract: The beneficial effects of lipoic acid (LA) in cancer treatment have been well documented in the last decade. Indeed, LA exerts crucial antiproliferative effects …
Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition.
PMID: FEBS Open Bio. 2020 Feb 23. Epub 2020 Feb 23. PMID: 32090494 Abstract Title: Alpha-lipoic acid inhibits lung cancer growth via mTOR-mediated autophagy inhibition. Abstract: Lung cancer is the leading cause of cancer-related death, and there remains a need for novel therapies for this malignancy. Here, we examined the effects of alpha-lipoic acid (LA), …
Alpha-Lipoic acid supplementation significantly reduces the risk of obesity.
PMID: Int J Clin Pract. 2020 Feb 24:e13493. Epub 2020 Feb 24. PMID: 32091656 Abstract Title: Alpha-Lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomized-placebo controlled clinical trials. Abstract: BACKGROUND: There are numerous trials reported the effect of ALA on obesity measurements; while no …
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This study suggests that use of natural antioxidants in combination with GNPs may be a useful tool in preventing gold nanoparticles toxicity.
PMID: Int J Nanomedicine. 2020 ;15:729-734. Epub 2020 Jan 31. PMID: 32099361 Abstract Title: The Protective Roles of Vitamin E andα-Lipoic Acid Against Nephrotoxicity, Lipid Peroxidation, and Inflammatory Damage Induced by Gold Nanoparticles. Abstract: Background: Recently, use of nanotechnology in biomedical applications such as drug delivery and diagnostic and therapeutic tools has increased greatly. This …
Alpha lipoic acid and Vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats.
PMID: Mitochondrion. 2020 Feb 28. Epub 2020 Feb 28. PMID: 32119925 Abstract Title: Alpha lipoic acid and Vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats. Abstract: To determine the effects of alpha lipoic acid (ALA) and vitamin E (Vit E) on mitochondrial dysfunction caused by statins. A total of 38 Wistar Albino rats were used …
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