Taylor Mercado

Diosmetin is a potential agent for prevention of liver cancer.

PMID: Oncol Lett. 2016 Dec ;12(6):5122-5128. Epub 2016 Nov 3. PMID: 28101238 Abstract Title: Diosmetin triggers cell apoptosis by activation of the p53/Bcl-2 pathway and inactivation of the Notch3/NF-κB pathway in HepG2 cells. Abstract: Diosmetin (DIOS), a flavonoid compound, is abundant in Citrus limon. Emerging studies have shown that DIOS is an effective compound implicated …

Continue reading “Diosmetin is a potential agent for prevention of liver cancer.”

Diosmetin induces cell apoptosis by regulating CYP1A1/CYP1A2 due to p53 activation in HepG2 cells.

PMID: Protein Pept Lett. 2017 May 10 ;24(5):406-412. PMID: 28245756 Abstract Title: Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells. Abstract: It was explored that CYP1 family of cytochromes P450 were over-expressed in several types of cancer. Our study aimed to characterize anti-proliferative activity and metabolism of the natural …

Continue reading “Diosmetin induces cell apoptosis by regulating CYP1A1/CYP1A2 due to p53 activation in HepG2 cells.”

Diosmetin alleviates lipopolysaccharide-induced acute lung injury.

PMID: Biomol Ther (Seoul). 2018 Mar 1 ;26(2):157-166. PMID: 28365974 Abstract Title: Diosmetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury through Activating the Nrf2 Pathway and Inhibiting the NLRP3 Inflammasome. Abstract: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse lung inflammation with high mortality rates and limited therapeutic methods. Diosmetin, …

Continue reading “Diosmetin alleviates lipopolysaccharide-induced acute lung injury.”

Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway

PMID: PLoS One. 2017 ;12(4):e0175977. Epub 2017 Apr 17. PMID: 28414793 Abstract Title: Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway. Abstract: Radiotherapy is a powerful tool in the treatment of cancer that has the advantage of preserving normal tissues. However, tumor radioresistance currently remains a major impediment to effective …

Continue reading “Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway”

Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure.

PMID: Oncotarget. 2017 May 9 ;8(19):30723-30733. PMID: 28430612 Abstract Title: Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice. Abstract: To investigate the effects and mechanism of diosmetin on acute hepatic failure (AHF), an AHF murine model was established through administration of lipopolysaccharides/D-galactosamine (LPS/D-GalN). In vitro, diosmetin scavenged …

Continue reading “Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure.”

Diosmetin protects against ischemia/reperfusion-induced acute kidney injury.

PMID: J Surg Res. 2017 06 15 ;214:69-78. Epub 2017 Mar 6. PMID: 28624062 Abstract Title: Diosmetin protects against ischemia/reperfusion-induced acute kidney injury in mice. Abstract: BACKGROUND: Renal ischemia/reperfusion (I/R)-induced acute kidney injury remains to be a troublesome condition in clinical practice. Although the exact molecular mechanisms underlying renal I/R injury are incompletely understood, the …

Continue reading “Diosmetin protects against ischemia/reperfusion-induced acute kidney injury.”

Diosmetin induces apoptosis of acute myeloid leukemia cells.

PMID: Mol Pharm. 2018 03 5 ;15(3):1353-1360. Epub 2018 Feb 7. PMID: 29412683 Abstract Title: Diosmetin Induces Apoptosis of Acute Myeloid Leukemia Cells. Abstract: Acute myeloid leukemia is an aggressive disease with limited and nonselective therapeutic options. This study explored the bioactivity and cell death inducing mechanism of diosmetin, a novel compound identified in a …

Continue reading “Diosmetin induces apoptosis of acute myeloid leukemia cells.”

Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage.

PMID: Mol Med Rep. 2018 May ;17(5):7331-7338. Epub 2018 Mar 15. PMID: 29568961 Abstract Title: Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway. Abstract: Oxidative stress is considered a crucial mediator in the pathogenesis of various liver diseases. The flavone diosmetin has been reported to …

Continue reading “Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage.”

Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest

PMID: Int J Oncol. 2018 Aug ;53(2):835-843. Epub 2018 May 16. PMID: 29767250 Abstract Title: Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest. Abstract: Diosmetin, a plant flavonoid, has been shown to exert promising effects on prostate cancer cells as an anti‑proliferative and anticancer agent. In this …

Continue reading “Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest”

This study shows that diosmetin protects against renal injury in STZ-induced diabetic nephropathy.

PMID: Med Sci Monit. 2018 Oct 2 ;24:7007-7014. Epub 2018 Oct 2. PMID: 30278036 Abstract Title: Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice. Abstract: BACKGROUND We evaluated the nephroprotective effect of diosmetin in streptozotocin (STZ)-induced diabetic nephropathy …

Continue reading “This study shows that diosmetin protects against renal injury in STZ-induced diabetic nephropathy.”