PMID: J Cell Physiol. 2019 Aug ;234(8):12701-12713. Epub 2018 Dec 4. PMID: 30515812 Abstract Title: Diosmetin inhibits osteoclast formation and differentiation and prevents LPS-induced osteolysis in mice. Abstract: Osteolytic bone diseases are closely linked to the over-activation of osteoclasts and enhancement of bone resorption. It has become a major health issue in orthopedic practice worldwide. …
Author Archives: Taylor Mercado
Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells.
PMID: Br J Pharmacol. 2019 Jun ;176(12):2079-2094. Epub 2019 May 11. PMID: 30825187 Abstract Title: Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells via Nrf2 inhibition. Abstract: BACKGROUND AND PURPOSE: Non-small-cell lung cancer (NSCLC) accounts for up to 80-85% of all lung cancers and has a disappointing …
Diosmetin reduced neuroinflammation and neuronal apoptosis in a model of pneumococcal meningitis.
PMID: Med Sci Monit. 2019 Mar 27 ;25:2238-2245. Epub 2019 Mar 27. PMID: 30914630 Abstract Title: Diosmetin Suppresses Neuronal Apoptosis and Inflammation by Modulating the Phosphoinositide 3-Kinase (PI3K)/AKT/Nuclear Factor-κB (NF-κB) Signaling Pathway in a Rat Model of Pneumococcal Meningitis. Abstract: Bacterial meningitis has a high mortality rate and can be challenging to diagnose and manage. …
These results extend the understanding of the anti-tumor mechanism of diosmetin.
PMID: Med Sci Monit. 2019 Jun 22 ;25:4639-4647. Epub 2019 Jun 22. PMID: 31228347 Abstract Title: Anti-Proliferation and Pro-Apoptotic Effects of Diosmetin via Modulating Cell Cycle Arrest and Mitochondria-Mediated Intrinsic Apoptotic Pathway in MDA-MB-231 Cells. Abstract: BACKGROUND Breast cancer is one of the most malignant tumors worldwide. The natural flavonoid diosmetin has been reported to …
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Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer
PMID: Biomed Pharmacother. 2019 Sep ;117:109091. Epub 2019 Jun 19. PMID: 31228803 Abstract Title: Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer. Abstract: Diosmetin is a natural flavonoid obtained from citrus fruits and some medicinal herbs. Previous studies have reported the anti-cancer activity of diosmetin in some types of tumors. However, it …
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Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.
PMID: Phytother Res. 2019 Dec 13. Epub 2019 Dec 13. PMID: 31833613 Abstract Title: Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways. Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation and proliferation of synovial tissues. Diosmetin is a …
Protective effect of Diosmin against benzo(a)pyrene-induced lung injury.
PMID: Environ Toxicol. 2020 Feb 15. Epub 2020 Feb 15. PMID: 32061149 Abstract Title: Protective effect of Diosmin against benzo(a)pyrene-induced lung injury in Swiss Albino Mice. Abstract: Diosmin, a naturally occurring flavonoid commonly present in citrus fruit, is known to exhibit anti-inflammatory, antimutagenic, antioxidant, and free radical scavenging as well as blood lipid lowering activities …
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Diosmin is a promising molecule for the treatment of inflammation and pain.
PMID: J Nat Prod. 2020 Feb 21. Epub 2020 Feb 21. PMID: 32083866 Abstract Title: Diosmin Treats Lipopolysaccharide-Induced Inflammatory Pain and Peritonitis by Blocking NF-κB Activation in Mice. Abstract: Gram-negative bacterial infections induce inflammation and pain. Lipopolysaccharide (LPS) is a pathogen-associated molecular pattern and the major constituent of Gram-negative bacterial cell walls. Diosmin is a …
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Diosmin and BEZ-235 (dactolisib) has synergistic anti-proliferative effects on HCT-116 colorectal cancer.
PMID: Mol Biol Rep. 2020 Feb 22. Epub 2020 Feb 22. PMID: 32088816 Abstract Title: The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through inhibition of the PI3K/Akt/mTOR/NF-κB axis. Abstract: One of the most lethal malignancies worldwide is colorectal cancer (CRC). Alterations in …
Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats.
PMID: Regul Toxicol Pharmacol. 2020 Feb 19:104622. Epub 2020 Feb 19. PMID: 32087353 Abstract Title: Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats. Abstract: The benchmark of this study is to evaluate the radio protective efficiency of diosmin, a natural citrus flavone of hesperidin derivative on …
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