Ethanolic extract of O. sanctum leaf exerted its anti-invasive effect on head and neck squamous cell carcinoma cells by attenuating MMP activity.

PMID:  Asian Pac J Cancer Prev. 2020 Feb 1 ;21(2):363-370. Epub 2020 Feb 1. PMID: 32102512 Abstract Title:  Ethanolic Extract of Ocimum sanctum Leaves Reduced Invasion and Matrix Metalloproteinase Activity of Head and Neck Cancer Cell Lines. Abstract:  BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) has a yearly incidence of 600,000 cases worldwide with …

Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells.

PMID:  Mol Biol Rep. 2020 Feb ;47(2):1021-1032. Epub 2019 Nov 26. PMID: 31773385 Abstract Title:  Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. Abstract:  The circadian timing system of mammals is synchronized in concert with a central clock, but is also influenced by …

Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

PMID:  J Cell Mol Med. 2020 Jan 30. Epub 2020 Jan 30. PMID: 32000299 Abstract Title:  Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice. Abstract:  Epidemiological studies have found that diabetes and cognitive dysfunction are closely related. Quercetin has been certified with the effect on improving diabetes mellitus (DM) and cognitive impairment. …

Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review

PMID:  J Ovarian Res. 2020 Jan 31 ;13(1):11. Epub 2020 Jan 31. PMID: 32005271 Abstract Title:  Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review. Abstract:  Polycystic ovary syndrome (PCOS) is a polygenic endocrine disorder and the most common gynecological endocrinopathy among reproductive-aged women. Current remedies are often used only to …

Quercetin alleviates LPS-induced depression-like behaviour.

PMID:  Front Pharmacol. 2019 ;10:1544. Epub 2020 Jan 17. PMID: 32009956 Abstract Title:  Quercetin Alleviates LPS-Induced Depression-Like Behavior in RatsRegulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC. Abstract:  Quercetin is a polyphenol with multiple biological activities, and results of our preliminary study showed that it could shorten the immobility time …

Both quercetin and quercitrin can inhibit LPS-induced macrophage inflammation and oxidative stress.

PMID:  Biomed Res Int. 2019 ;2019:7039802. Epub 2019 Oct 28. PMID: 31781635 Abstract Title:  Quercetin and Quercitrin Attenuates the Inflammatory Response and Oxidative Stress in LPS-Induced RAW264.7 Cells: In Vitro Assessment and a Theoretical Model. Abstract:  Background: Nowadays, atmospheric pollutants, ultraviolet rays, and other factors cause the imbalance of cell redox, resulting in skin oxidative …

Quercetin improves endothelial insulin sensitivity in obese mice.

PMID:  Acta Biochim Biophys Sin (Shanghai). 2019 Dec 13 ;51(12):1250-1257. PMID: 31781748 Abstract Title:  Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting Drp1 phosphorylation at serine 616 and mitochondrial fragmentation. Abstract:  Studies have shown that endothelial insulin resistance induced by oxidative stress contributes to vascular dysfunction in metabolic disorders. Quercetin, a natural antioxidant, …

Quercetin suppresses the progression of atherosclerosis.

PMID:  Int J Mol Sci. 2019 Dec 3 ;20(23). Epub 2019 Dec 3. PMID: 31816893 Abstract Title:  Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. Abstract:  OBJECTIVE: To investigate the process by which quercetin suppresses atherosclerosis by upregulating MST1-mediated autophagy in RAW264.7 macrophages.METHODS: An in vitro foam …

Mechanism of synergy between tetracycline and quercetin against antibiotic resistant Escherichia coli.

PMID:  Front Microbiol. 2019 ;10:2536. Epub 2019 Nov 22. PMID: 31824439 Abstract Title:  Mechanism of Synergy Between Tetracycline and Quercetin Against Antibiotic Resistant. Abstract:  Treatment of multi-drug resistant (MDR)intestinal infections are being hampered by the presence of the-1 (colistin) and(tetracycline) resistance genes in these strains. We screened seven traditional Chinese medicines for their ability to …

Resveratrol and quercetin attenuate depressive-like behavior and restore impaired contractility.

PMID:  Naunyn Schmiedebergs Arch Pharmacol. 2019 Dec 14. Epub 2019 Dec 14. PMID: 31836917 Abstract Title:  Resveratrol and quercetin attenuate depressive-like behavior and restore impaired contractility of vas deferens in chronic stress-exposed rats: involvement of oxidative stress and inflammation. Abstract:  Chronic stress is associated with male sexual problems including ejaculatory dysfunctions. The aim of this …

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