PMID: Int J Immunopathol Pharmacol. 2011 Oct-Dec;24(4):1057-68. PMID: 22230411 Abstract Title: Lactoferrin decreases inflammatory response by cystic fibrosis bronchial cells invaded with Burkholderia cenocepacia iron-modulated biofilm. Abstract: In cystic fibrosis (CF) high iron concentration in airway secretion plays a pivotal role in bacterial multiplication and biofilm formation as well as in inflammatory response. Burkholderia cenocepacia, …
Author Archives: Taylor Mercado
Lactoferrin inhibits the endotoxin interaction with CD14 by competition with the lipopolysaccharide-binding protein.
PMID: Infect Immun. 1998 Feb ;66(2):486-91. PMID: 9453600 Abstract Title: Lactoferrin inhibits the endotoxin interaction with CD14 by competition with the lipopolysaccharide-binding protein. Abstract: Human lactoferrin (hLf), a glycoprotein released from neutrophil granules during inflammation, and the lipopolysaccharide (LPS)-binding protein (LBP), an acute-phase serum protein, are known to bind to the lipid A of LPS. …
These studies indicate that lactoferrin may be a novel therapeutic for the treatment of tuberculosis.
PMID: Tuberculosis (Edinb). 2011 Dec ;91 Suppl 1:S105-13. Epub 2011 Dec 3. PMID: 22138562 Abstract Title: Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology. Abstract: The ability of lactoferrin to provide protection and decrease immunopathology in infectious diseases was evaluated using an aggressive aerosol model of Mycobacterium tuberculosis (MTB) infection. C57BL/6 mice were challenged …
Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model.
PMID: Innate Immun. 2010 Apr ;16(2):67-79. Epub 2009 Sep 1. PMID: 19723832 Abstract Title: Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model. Abstract: Lactoferrin is a non-heme iron-binding glycoprotein, produced by mucosal epithelial cells and granulocytes in most mammalian species. It is involved in regulation of immune responses, possesses anti-oxidant, …
Oral lactoferrin treatment resolves amoebic intracecal infection in C3H/HeJ mice.
PMID: Biochem Cell Biol. 2012 Jun ;90(3):435-41. Epub 2012 Mar 27. PMID: 22452668 Abstract Title: Oral lactoferrin treatment resolves amoebic intracecal infection in C3H/HeJ mice. Abstract: Entamoeba histolytica is a protozoan parasite that causes amoebiasis, an illness that affects many people around the world. We have previously reported that lactoferrin is able to kill E. …
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Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms.
PMID: Scand J Immunol. 2013 Dec ;78(6):507-15. PMID: 24111738 Abstract Title: Lactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanisms. Abstract: Lactoferrin (LF) can downregulate allergic airway inflammation in asthma. However, the in vivo effect of exogenous LF on allergic rhinitis (AR), a disease attributed to airway inflammation, has yet to be …
Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway.
PMID: Int Immunopharmacol. 2015 Sep ;28(1):695-9. Epub 2015 Aug 6. PMID: 26256698 Abstract Title: Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway. Abstract: Lactoferrin (LF) is one of the most abundant proteins found in milk, and it has been reported to have anti-inflammatory properties. However, the anti-inflammatory effects of LF on …
Recombinant human lactoferrin enhances the efficacy of triple therapy in mice infected with Helicobacter pylori.
PMID: Int J Mol Med. 2015 Aug ;36(2):363-8. Epub 2015 Jun 17. PMID: 26080893 Abstract Title: Recombinant human lactoferrin enhances the efficacy of triple therapy in mice infected with Helicobacter pylori. Abstract: Helicobacter pylori (H. pylori) is a life-threatening pathogen which causes chronic gastritis, gastric ulcers and even stomach cancer. Treatment normally involves bacterial eradication; …
Effects of lactoferrin in 6 patients with refractory bacterial vaginosis.
PMID: Biochem Cell Biol. 2017 02 ;95(1):31-33. Epub 2016 Aug 17. PMID: 28140620 Abstract Title: Effects of lactoferrin in 6 patients with refractory bacterial vaginosis. Abstract: We previously reported that lactoferrin (LF) could be effective for preventing preterm delivery and intrauterine infections, based on data derived from mice and rabbits. Here we describe 6 women …
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A pilot study on the effect of lactoferrin on Alzheimer’s disease pathological sequelae.
PMID: Biomed Pharmacother. 2019 Mar ;111:714-723. Epub 2019 Jan 3. PMID: 30611996 Abstract Title: A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway. Abstract: Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in which the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (PKB or Akt) …
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