PMID: Mediators Inflamm. 2015 ;2015:409596. Epub 2015 Dec 14. PMID: 26788020 Abstract Title: Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology. Abstract: There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a"firebreak"to slow transmission. A promising avenue to increase …
Author Archives: Taylor Mercado
Multi-target anti-Alzheimer activities of four prenylated compounds from Psoralea Fructus.
PMID: Molecules. 2018 Mar 8 ;23(3). Epub 2018 Mar 8. PMID: 29518051 Abstract Title: Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus. Abstract: Alzheimer's disease (AD) is an age-related neurodegenerative disease that is mediated by multiple signaling pathways. In recent years, the components of(PF) have demonstrated some anti-Alzheimer effects both in vitro and …
Zerumbone effectively ameliorated behavioral impairments, attenuated neuroinflammation, and reduced β-amyloid deposition in transgenic APP/PS1 mice.
PMID: J Neuroinflammation. 2020 Feb 17 ;17(1):61. Epub 2020 Feb 17. PMID: 32066466 Abstract Title: Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling. Abstract: BACKGROUND: Alzheimer's disease (AD) is a major clinical problem, but there is a distinct lack of effective therapeutic drugs for this disease. We investigated the …
Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase.
PMID: Oncotarget. 2016 Mar 22 ;7(12):14616-27. PMID: 26910280 Abstract Title: Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase. Abstract: Bakuchiol is a meroterpene present in the medicinal plant Psoralea corylifolia, which has been traditionally used in China, India, Japan and Korea for the treatment of premature ejaculation, …
Bakuchiol is a phenolic isoprenoid with novel enantiomer-selective anti-influenza A virus activity involving Nrf2 activation.
PMID: J Biol Chem. 2015 Nov 13 ;290(46):28001-17. Epub 2015 Oct 7. PMID: 26446794 Abstract Title: Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation. Abstract: Influenza represents a substantial threat to human health and requires novel therapeutic approaches. Bakuchiol is a phenolic isoprenoid compound present in Babchi (Psoralea …
These findings demonstrated that bakuchiol possesses potential for treating human gastric cancer.
PMID: Mol Med Rep. 2017 Dec ;16(6):8977-8982. Epub 2017 Oct 3. PMID: 28990045 Abstract Title: Anti‑tumor effects of bakuchiol on human gastric carcinoma cell lines are mediated through PI3K/AKT and MAPK signaling pathways. Abstract: Bakuchiol is extracted from Psoralea corylifolia, a member of the Leguminosae family, has been used in Indian Ayurvedic and Chinese traditional medicine, …
Psoralen attenuates bleomycin-induced pulmonary fibrosis.
PMID: Cell Biol Int. 2019 Jul 22. Epub 2019 Jul 22. PMID: 31329322 Abstract Title: Psoralen attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting myofibroblast activation and collagen deposition. Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by excessive deposition of extracellular matrix (ECM) and chronic inflammation with limited therapeutic options. Psoralen, a …
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Bavachin induces the apoptosis of multiple myeloma cell lines.
PMID: Biomed Pharmacother. 2018 Apr ;100:486-494. Epub 2018 Feb 23. PMID: 29477912 Abstract Title: Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3. Abstract: Bavachin is a phytoestrogen purified from natural herbal plants such as Psoralea corylifolia. In …
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DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia.
PMID: J Nat Prod. 1998 Mar ;61(3):362-6. PMID: 9544566 Abstract Title: DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. Abstract: An ethanol extract of Psoralea corylifolia caused strong DNA polymerase inhibition in a whole cell bioassay specific for inhibitors of DNA replication enzymes. Bioassay-directed purification of the active compounds led to the isolation of …
Continue reading “DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia.”
Protective role of Psoralea corylifolia seed extract against hepatic mitochondrial dysfunction induced by oxidative stress or aging.
PMID: Evid Based Complement Alternat Med. 2013 ;2013:678028. Epub 2013 Aug 29. PMID: 24069053 Abstract Title: Protective Role of Psoralea corylifolia L. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging. Abstract: The accumulation of oxidative damage and mitochondrial dysfunction is an important factor that contributes to aging. The Psoralea corylifolia seeds …
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