Author Archives: Taylor Mercado

PMID:  Fitoterapia. 2000 Jun ;71(3):223-31. PMID: 10844159 Abstract Title:  Immunomodulatory and antitumour properties of Psoralea corylifolia seeds. Abstract:  Psoralea corylifolia seed extract has been found to stimulate the immune system in mice. Administration of the extract was found to inhibit EAC ascitic tumour growth and stimulate natural killer cell activity, antibody-dependent cellular cytotoxicity, antibody-forming cells …

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PMID:  BMC Complement Altern Med. 2016 Sep 26 ;16(1):373. Epub 2016 Sep 26. PMID: 27670681 Abstract Title:  Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells. Abstract:  BACKGROUND: Psoralea Fructus (PF), the dried and ripe fruit of Psoralea corylifolia exhibits an anti-cancer activity. However, the molecular …

Continue reading “Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells.”

PMID:  Cell Biochem Biophys. 2014 Nov ;70(2):1075-81. PMID: 24845152 Abstract Title:  Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by psoralen from Psoralea corylifolia. Abstract:  Psoralen is a major active component of Psoralea corylifolia. In the present study, we analyzed psoralen-induced changes in human hepatocarcinoma cell viability and apoptosis, and investigated the underlying …

Continue reading “Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by psoralen from Psoralea corylifolia.”

PMID:  Am J Chin Med. 2007 ;35(4):669-80. PMID: 17708633 Abstract Title:  Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats. Abstract:  We evaluated the protective effect of Psoralea corylifolia L. (PCL) extract on the ovariectomized (OVX) rat model. The biochemical markers of bone turnover, calcium metabolism, and calcium balance were examined. PCL extract (25 mg …

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PMID:  Mol Cell Endocrinol. 2015 Dec 5 ;417:103-13. Epub 2015 Sep 28. PMID: 26419930 Abstract Title:  Positive skeletal effect of two ingredients of Psoralea corylifolia L. on estrogen deficiency-induced osteoporosis and the possible mechanisms of action. Abstract:  Estrogen replacement therapy (ERT) is utilized as a major regime for treatment of postmenopausal osteoporosis at present. However, …

Continue reading “Positive skeletal effect of two ingredients of Psoralea corylifolia L. on estrogen deficiency-induced osteoporosis and the possible mechanisms of action.”

PMID:  J Environ Pathol Toxicol Oncol. 2014 ;33(3):265-77. PMID: 25272064 Abstract Title:  Mechanism of cytotoxicity by Psoralea corylifolia extract in human breast carcinoma cells. Abstract:  Psoralea corylifolia has been widely used in herbal medicine, and a few studies show its anticancer activity. However, the detailed mechanism of the anticancer activity of P. corylifolia seed extract …

Continue reading “Mechanism of cytotoxicity by Psoralea corylifolia extract in human breast carcinoma cells.”

PMID:  Zhongguo Zhong Yao Za Zhi. 2017 Jul ;42(13):2546-2551. PMID: 28840697 Abstract Title:  [Effect of Psoralea corylifolia in treating fatty liver disease in juvenal mouse by inhibiting hepatic NF-κB activation]. Abstract:  To investigate the mechanism and effect of Psoralea corylifolia(PC) in the treatment of NAFLD in juvenal mice. The NAFLD model in juvenal mice was …

Continue reading “Effect of Psoralea corylifolia in treating fatty liver disease in juvenal mouse by inhibiting hepatic NF-κB activation”

PMID:  Oxid Med Cell Longev. 2014 ;2014:897296. Epub 2014 Apr 3. PMID: 24803987 Abstract Title:  Psoralea corylifolia L. seed extract ameliorates streptozotocin-induced diabetes in mice by inhibition of oxidative stress. Abstract:  Pancreatic beta-cell death is known to be the cause of deficient insulin production in diabetes mellitus. Oxidative stress is one of the major causes …

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PMID:  J Microencapsul. 2019 Mar ;36(2):140-155. Epub 2019 May 20. PMID: 31030587 Abstract Title:  Enhanced anti-psoriatic efficacy and regulation of oxidative stress of a novel topical babchi oil () cyclodextrin-based nanogel in a mouse tail model. Abstract:  Psoriasis is a proliferative inflammatory skin disorder with relapsing episodes. Herein, the efficacy of babchi oil (BO) loaded …

Continue reading “Enhanced anti-psoriatic efficacy and regulation of oxidative stress of a novel topical babchi oil cyclodextrin-based nanogel.”

PMID:  Oncol Rep. 2015 Oct ;34(4):2040-6. Epub 2015 Jul 27. PMID: 26238218 Abstract Title:  Aqueous extract of Psoralea corylifolia L. inhibits lipopolysaccharide-induced endothelial-mesenchymal transition via downregulation of the NF-κB-SNAIL signaling pathway. Abstract:  The epithelial-mesenchymal transition (EMT) is a pivotal event in the invasion and metastasis of cancer cells. Psoralea corylifolia L. (PC) inhibits the proliferation of …

Continue reading “Psoralea corylifolia is a potentially effective dietary chemopreventive agent for malignant tumors since it inhibits metastasis.”