PMID: Viruses. 2019 01 11 ;11(1). Epub 2019 Jan 11. PMID: 30641890 Abstract Title: Bovine Lactoferrin Prevents Influenza A Virus Infection by Interfering with the Fusogenic Function of Viral Hemagglutinin. Abstract: Bovine lactoferrin (bLf) is an iron-binding glycoprotein folded in two symmetric globular lobes (N- and C-lobes) with potent antimicrobial and immunomodulatory activities. Recently, we …
Author Archives: Taylor Mercado
Lactoferrin for prevention of common viral infections.
PMID: J Infect Chemother. 2014 Nov ;20(11):666-71. Epub 2014 Aug 30. PMID: 25182867 Abstract Title: Lactoferrin for prevention of common viral infections. Abstract: Although lactoferrin has many biological functions, the host-protective effects against pathogenic microorganisms including bacteria, fungi, and viruses are regarded as one of the most important. Here, we review research on the protective …
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Lactoferrin protects against concanavalin A-induced liver injury.
PMID: Liver Int. 2010 Apr ;30(4):623-32. Epub 2010 Jan 29. PMID: 20136718 Abstract Title: Lactoferrin protects against concanavalin A-induced liver injury in mice. Abstract: BACKGROUND: Liver diseases, caused by viral infection, autoimmune conditions, alcohol ingestion or the use of certain drugs, are a significant health issue, as many can develop into liver failure. Lactoferrin (Lac) …
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In vitro antioxidative potential of lactoferrin and black tea polyphenols and protective effects in vivo on carcinogen activation.
PMID: Oncol Res. 2008 ;17(5):193-203. PMID: 18980016 Abstract Title: In vitro antioxidative potential of lactoferrin and black tea polyphenols and protective effects in vivo on carcinogen activation, DNA damage, proliferation, invasion, and angiogenesis during experimental oral carcinogenesis. Abstract: The present study was designed to evaluate the in vitro antioxidant potential of bovine lactoferrin (bLF) and …
Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response.
PMID: Lab Invest. 2014 Nov ;94(11):1188-99. Epub 2014 Jul 28. PMID: 25068657 Abstract Title: Lactoferrin suppresses the Epstein-Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9. Abstract: Epstein-Barr virus (EBV) infection contributes to tumorigenesis of various human malignancies including nasopharyngeal carcinoma (NPC). EBV triggers innate immune and inflammatory responses partly through …
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Apoptotic effects of bovine apo-lactoferrin on HeLa tumor cells.
PMID: Cell Biochem Funct. 2017 Jan ;35(1):33-41. Epub 2017 Jan 3. PMID: 28052347 Abstract Title: Apoptotic effects of bovine apo-lactoferrin on HeLa tumor cells. Abstract: Lactoferrin (Lf), a cationic iron-binding glycoprotein of 80 kDa present in body secretions, is known as a compound with marked antimicrobial activity. In the present study, the apoptotic effect of iron-free …
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Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas.
PMID: Eur J Pharm Sci. 2011 Sep 18 ;44(1-2):164-73. Epub 2011 Jul 18. PMID: 21782939 Abstract Title: Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas. Abstract: In this study, a brain-targeted chemotherapeutical delivery system, doxorubicin-loaded lactoferrin-modified procationic liposome (DOX-Lf-PCL) was developed, and its therapeutic effect for glioma was evaluated. The uptake profile of …
Lactoferrin induces growth arrest and nuclear accumulation of Smad-2 in HeLa cells.
PMID: Biochimie. 2010 Jul ;92(7):880-4. Epub 2010 Mar 25. PMID: 20347004 Abstract Title: Lactoferrin induces growth arrest and nuclear accumulation of Smad-2 in HeLa cells. Abstract: Lactoferrin (Lf) is a multifunctional glycoprotein. Due to its anti-inflammatory and anti-cancer properties and the resulting therapeutical potential, lactoferrin is at present focus of a variety of research areas. …
Lactoferrin reduces methotrexate-induced small intestinal damage.
PMID: Dig Dis Sci. 2004 Mar ;49(3):425-33. PMID: 15139492 Abstract Title: Lactoferrin reduces methotrexate-induced small intestinal damage, possibly through inhibition of GLP-2-mediated epithelial cell proliferation. Abstract: A strategy protecting the small intestine against deleterious side effects associated with anti-cancer therapy is arresting epithelial cell cycling temporally. Since endogenous glucagon-like peptide-2 (GLP-2) is a trophic factor …
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Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma.
PMID: Mol Pharm. 2010 Dec 6 ;7(6):1995-2005. Epub 2010 Oct 28. PMID: 20957995 Abstract Title: Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma rats. Abstract: The blood-brain barrier (BBB) and multidrug resistance (MDR) are the main causes for poor prognosis of glioma patients after chemotherapy. To explore the way for settling this …
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