PMID: Biochem Biophys Res Commun. 1997 Aug 28 ;237(3):624-8. PMID: 9299415 Abstract Title: Apoptosis in human leukemic cells induced by lactoferricin, a bovine milk protein-derived peptide: involvement of reactive oxygen species. Abstract: We examined the activity of bovine lactoferricin (Lfcin-B), a peptide derived from a bovine milk protein lactoferrin (LF-B), to induce apoptosis in THP-1 …
Author Archives: Taylor Mercado
Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin.
PMID: Biofactors. 2000 ;12(1-4):83-8. PMID: 11216510 Abstract Title: Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals. Abstract: Bovine lactoferrin (bLF), a milk protein known to have bacteriostatic properties was examined for its preventive effects on colon and other organ carcinogenesis and experimental metastasis. (Experiment 1) The influence on colon …
Orally administered bovine lactoferrin systemically inhibits VEGF (165)-mediated angiogenesis.
PMID: Int J Cancer. 2001 Jan 15 ;91(2):236-40. PMID: 11146451 Abstract Title: Orally administered bovine lactoferrin systemically inhibits VEGF(165)-mediated angiogenesis in the rat. Abstract: Lactoferrin (Lf) systemically suppresses tumor growth and metastasis by unknown mechanisms. We have studied the effect of orally administered iron-unsaturated bovine Lf on angiogenesis induced by VEGF(165) and IL-1-alpha in adult …
Lactoferrin-induced up-regulation of zeta (zeta) chain expression in peripheral blood T lymphocytes from cervical cancer patients.
PMID: Anticancer Res. 2002 May-Jun;22(3):1897-901. PMID: 12168890 Abstract Title: Lactoferrin-induced up-regulation of zeta (zeta) chain expression in peripheral blood T lymphocytes from cervical cancer patients. Abstract: Alteration of T-cell-associated signal transduction molecules has recently been implicated in immune suppression in tumour-bearing hosts. Here we report the immunoregulatory effects of human lactoferrin (LF) on zeta-chain expression …
Lactoferrin could inhibit the expression of VEGF, bFGFmRNA and protein in Tca8113 cells.
PMID: Zhonghua Kou Qiang Yi Xue Za Zhi. 2010 Jan ;45(1):28-30. PMID: 20368037 Abstract Title: [Effects of lactoferrin on vascular endothelial growth factor and basic fibroblast growth factor expression in human Tca8113 cell line]. Abstract: OBJECTIVE: To investigate the effect of lactoferrin on vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) expression.METHODS: …
A lactoferrin-derived peptide with cationic residues concentrated in a region of its helical structure induces necrotic cell death in a leukemic cell line (HL-60).
PMID: J Pept Sci. 2008 Sep ;14(9):1032-8. PMID: 18425992 Abstract Title: A lactoferrin-derived peptide with cationic residues concentrated in a region of its helical structure induces necrotic cell death in a leukemic cell line (HL-60). Abstract: Model studies have shown that peptides derived from the N-terminal region of bovine lactoferrin (Lf-B) exhibit antitumor activity against …
This study indicated that artemisinin alleviated atherosclerotic lesions.
PMID: J Cardiovasc Pharmacol. 2019 Dec 31. Epub 2019 Dec 31. PMID: 31895870 Abstract Title: Artemisinin attenuated atherosclerosis in high-fat diet-fed ApoE-/- mice by promoting macrophage autophagy via AMPK/mTOR/ULK1 pathway. Abstract: Artemisinin is an endoperoxide sesquiterpene lactone from Artemisia annua L with multiple beneficial effects, including anti-inflammation, anti-oxidant and vascular protection. Recent studies have found …
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Artemisinin attenuates doxorubicin induced cardiotoxicity and hepatotoxicity.
PMID: Biotech Histochem. 2020 Feb ;95(2):121-128. Epub 2019 Sep 6. PMID: 32064961 Abstract Title: Artemisinin attenuates doxorubicin induced cardiotoxicity and hepatotoxicity in rats. Abstract: We investigated the effects of artemisinin on doxorubicin (Dox) induced heart and liver pathology in rats. We divided 49 male rats into seven groups: group 1 was the untreated control. Dox …
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E2F1-directed activation of Bcl-2 is correlated with lactoferrin-induced apoptosis in Jurkat leukemia T lymphocytes.
PMID: Biometals. 2010 Jun ;23(3):507-14. Epub 2010 Apr 22. PMID: 20411301 Abstract Title: E2F1-directed activation of Bcl-2 is correlated with lactoferrin-induced apoptosis in Jurkat leukemia T lymphocytes. Abstract: Lactoferrin (Lf) has been shown to control the proliferation of a variety of mammalian cells. Recently, we reported that human Lf induces apoptosis via a c-Jun N-terminal …
Lack of chronic oral toxicity of chemopreventive bovine lactoferrin.
PMID: Asian Pac J Cancer Prev. 2008 Apr-Jun;9(2):313-6. PMID: 18712982 Abstract Title: Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats. Abstract: Studies were undertaken to determine whether bovine lactoferrin (bLF) and related compounds, shown to prevent carcinogenesis in the colon and other organs in rats, have any toxic effects in long-term …
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