PMID: Int J Cancer. 2004 Sep 1 ;111(3):398-403. PMID: 15221967 Abstract Title: Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy. Abstract: In this work, we investigated the anticancer activity of orally administered recombinant human lactoferrin (rhLF) alone and in combination with chemotherapy in tumor-bearing mice. rhLF inhibited the growth of squamous cell …
Author Archives: Taylor Mercado
Human lactoferrin inhibits growth of solid tumors and development of experimental metastases.
PMID: Cancer Res. 1994 May 1 ;54(9):2310-2. PMID: 8162571 Abstract Title: Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Abstract: The antitumor effects of the multifunctional iron-binding glycoprotein, lactoferrin (Lf), were investigated. Lf inhibited growth in mice of transplantable solid tumors induced by v-ras transformed fibroblasts and a methylcholanthrene-induced …
Lactoferrin is one potential candidate as an anti‐HCV reagent that may be effective for the treatment of patients with chronic hepatitis.
PMID: Jpn J Cancer Res. 1999 Apr ;90(4):367-71. PMID: 10363572 Abstract Title: Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study. Abstract: Hepatitis C virus (HCV) is associated with the development of cirrhosis and hepatocellular carcinoma. We recently found that bovine lactoferrin, a milk protein belonging to the iron …
Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro.
PMID: J Infect Dis. 2002 Oct 15 ;186(8):1161-4. Epub 2002 Sep 16. PMID: 12355368 Abstract Title: Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro. Abstract: Enterovirus 71 (EV71), the newest member of Enterovirudae, is notable for its etiological role in epidemics of severe neurological diseases in children. It appears to be …
Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes.
PMID: Biochem Biophys Res Commun. 1998 Apr 17 ;245(2):549-53. PMID: 9571193 Abstract Title: Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes. Abstract: We found that bovine lactoferrin (bLF), a milk protein belonging to the iron transporter family, effectively prevented hepatitis C virus (HCV) infection in cultured human hepatocytes (PH5CH8), a cell line …
Bovine lactoferrin induces cell cycle arrest and inhibits mTOR signaling in breast cancer cells.
PMID: Nutr Cancer. 2014 ;66(8):1371-85. Epub 2014 Oct 30. PMID: 25356800 Abstract Title: Bovine lactoferrin induces cell cycle arrest and inhibits mTOR signaling in breast cancer cells. Abstract: Lactoferrin (LF) is predominantly found in mammalian secretions with recognized anticancer potential, although the mechanisms involved in such activity are still unclear. Here, the stability, internalization, and …
Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates.
PMID: Early Hum Dev. 2014 Mar ;90 Suppl 1:S60-5. PMID: 24709463 Abstract Title: Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial. Abstract: IMPORTANCE: NEC is a common and severe complication in premature neonates, particularly those with very-low-birth-weight (VLBW, read more
Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats.
PMID: Carcinogenesis. 2004 Oct ;25(10):1961-6. Epub 2004 Jun 10. PMID: 15192017 Abstract Title: Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats. Abstract: Bovine lactoferrin, a multifunctional glycoprotein, has been shown to strongly inhibit development of azoxymethane (AOM)-induced rat colon tumors. Little, however, is known about the inhibitory mechanisms. We have …
miR-214 regulates lactoferrin expression and pro-apoptotic function in mammary epithelial cells.
PMID: J Nutr. 2010 Sep ;140(9):1552-6. Epub 2010 Jul 7. PMID: 20610637 Abstract Title: miR-214 regulates lactoferrin expression and pro-apoptotic function in mammary epithelial cells. Abstract: Lactoferrin (Lf) is an abundantly expressed protein in human milk. Lactoferrin exhibits several important biological functions, and its expression is regulated by multiple environmental factors. Cellular endogenous factors, however, …
Lactoferrin inhibits growth of malignant tumors of the head and neck.
PMID: ORL J Otorhinolaryngol Relat Spec. 2003 Sep-Oct;65(5):245-9. PMID: 14730178 Abstract Title: Lactoferrin inhibits growth of malignant tumors of the head and neck. Abstract: Lactoferrin, a naturally occurring glycoprotein found in breast milk, has previously been shown to have antimicrobial properties and recently has been demonstrated to inhibit malignant tumor growth, presumably through immunomodulation. We …
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