PMID: Biometals. 2011 Aug ;24(4):585-94. Epub 2011 Feb 16. PMID: 21327478 Abstract Title: Lactoferrin: an iron-binding antimicrobial protein against Escherichia coli infection. Abstract: Escherichia coli (E. coli) are the most common aerobic gram-negative bacilli in a normal intestinal tract. They cause most of the intra-abdominal infections, wound infections associated with abdominal surgery, and septicemia. Most …
Author Archives: Taylor Mercado
Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells.
PMID: Clin Cancer Res. 2004 Dec 15 ;10(24):8683-6. PMID: 15623653 Abstract Title: Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells. Abstract: The molecular mechanism of lactoferrin-induced cell growth inhibition is incompletely understood. Studying head and neck cancer cells treated with human lactoferrin, we observed growth arrest in three of …
The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma.
PMID: Exp Oncol. 2019 Mar ;41(1):20-25. PMID: 30932415 Abstract Title: The influence of lactoferrin on elemental homeostasis and activity of metal-containing enzymes in rats with Walker-256 carcinosarcoma. Abstract: AIM: To investigate the content of essential elements (EE): copper, zinc, magnesium, iron and calcium and the evaluation of the activity of metal-containing enzymes – ceruloplasmin (CP), myeloperoxidase (MPO) …
Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin
PMID: J Dairy Sci. 2010 Jun ;93(6):2344-50. PMID: 20494139 Abstract Title: Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin. Abstract: Lactoferrin, a protein from bovine milk belonging to the transferring family proteins, contains 2 bound Fe(+3) ions. Recent research has revealed that lactoferrin exhibits not only antimicrobial …
Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma.
PMID: Int J Nanomedicine. 2015 ;10:5123-37. Epub 2015 Aug 12. PMID: 26316745 Abstract Title: Lactoferrin-modified PEGylated liposomes loaded with doxorubicin for targeting delivery to hepatocellular carcinoma. Abstract: Lactoferrin (Lf) is a potential-targeting ligand for hepatocellular carcinoma (HCC) cells because of its specific binding with asialoglycoprotein receptor (ASGPR). In this present work, a doxorubicin (DOX)-loaded, Lf-modified, …
Bovine lactoferrin: benefits and mechanism of action against infections.
PMID: Biochem Cell Biol. 2006 Jun ;84(3):291-6. PMID: 16936799 Abstract Title: Bovine lactoferrin: benefits and mechanism of action against infections. Abstract: Ingestion of bovine lactoferrin (bLF) has been reported to show anti-infective, anti-cancer, and anti-inflammatory effects. In particular, it has become evident that oral bLF had a beneficial effect on infections of both digestive and …
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Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production.
PMID: Sci Rep. 2018 12 21 ;8(1):18020. Epub 2018 Dec 21. PMID: 30575774 Abstract Title: Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production. Abstract: Lactoferrin (LF) is an 80 KDa iron-binding glycoprotein that plays a significant role in the innate immune system and is considered to be an important microbicide …
Molecular mechanisms underlying the inhibitory effects of bovine lactoferrin on osteosarcoma.
PMID: Biochem Biophys Res Commun. 2019 01 15 ;508(3):946-952. Epub 2018 Dec 10. PMID: 30545626 Abstract Title: Molecular mechanisms underlying the inhibitory effects of bovine lactoferrin on osteosarcoma. Abstract: Osteosarcoma (OS) is one the most common primary malignancies of the bone in children and young adults with high metastasis. The use of non-toxic naturally derived …
Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation and expression of vascular endothelial growth factor.
PMID: J Dairy Sci. 2013 Apr ;96(4):2095-2106. Epub 2013 Feb 22. PMID: 23462173 Abstract Title: Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation and expression of vascular endothelial growth factor. Abstract: Lung cancers are among the most common cancers in the world, and the search for effective and safe drugs for the …
Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma.
PMID: PLoS One. 2018 ;13(1):e0191683. Epub 2018 Jan 30. PMID: 29381751 Abstract Title: Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma. Abstract: BACKGROUND: Lactoferrin (LF), a member of the transferrin family, recently has been demonstrated to have anticancer effects on various cancers including oral squamous cell carcinoma …
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