PMID: J Agric Food Chem. 2019 Jan 9 ;67(1):140-147. Epub 2018 Nov 27. PMID: 30418775 Abstract Title: Effect of Heat Treatment on the Antitumor Activity of Lactoferrin in Human Colon Tumor (HT29) Model. Abstract: To investigate the effect of heat treatment on the antitumor activity of lactoferrin in colon cancer cells and colon tumors, the …
Author Archives: Taylor Mercado
Lactoferrin induced neuronal differentiation: A boon for brain tumours.
PMID: Int J Dev Neurosci. 2015 Apr ;41:28-36. Epub 2014 Dec 8. PMID: 25498991 Abstract Title: Lactoferrin induced neuronal differentiation: A boon for brain tumours. Abstract: The cumulative treatments of bovine lactoferrin (bLf) and iron saturated lactoferrin (Fe-bLf) in the neuroblastoma cells showed neuronal differentiating actions evident with the expression of specific differentiating markers,β-tubulin III …
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Lactoferrin nanoparticle mediated targeted delivery of 5-fluorouracil for enhanced therapeutic efficacy.
PMID: Int J Biol Macromol. 2017 Feb ;95:232-237. Epub 2016 Nov 15. PMID: 27864056 Abstract Title: Lactoferrin nanoparticle mediated targeted delivery of 5-fluorouracil for enhanced therapeutic efficacy. Abstract: Malignant melanoma is an aggressive form of skin cancer with high mortality rates. Common treatments for malignant melanoma involve a combination of radiotherapy and chemotherapy with fluorouracil …
Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats.
PMID: Exp Oncol. 2018 Oct ;40(3):200-204. PMID: 30284996 Abstract Title: Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats. Abstract: AIM: To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF.MATERIALS AND METHODS: The study was performed on Walker-256 tumor-bearing …
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Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition to mesenchymal-to-epithelial transition in oral squamous cell carcinoma.
PMID: Biochem Biophys Res Commun. 2018 12 9 ;507(1-4):142-147. Epub 2018 Nov 8. PMID: 30415774 Abstract Title: Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition to mesenchymal-to-epithelial transition in oral squamous cell carcinoma. Abstract: Epithelial-to-mesenchymal transition (EMT) is a biological process of invasion and metastasis in cancers, including in oral squamous cell carcinoma (OSCC). However, an …
Lactoferrin exerts antitumor effects by inhibiting angiogenesis in a HT29 human colon tumor model.
PMID: J Agric Food Chem. 2017 Dec 6 ;65(48):10464-10472. Epub 2017 Nov 20. PMID: 29112400 Abstract Title: Lactoferrin Exerts Antitumor Effects by Inhibiting Angiogenesis in a HT29 Human Colon Tumor Model. Abstract: To investigate the effect and potential mechanisms of lactoferrin on colon cancer cells and tumors, HT29 and HCT8 cells were exposed to varying …
Cancer prevention by bovine lactoferrin: from animal studies to human trial.
PMID: Biometals. 2010 Jun ;23(3):399-409. Epub 2010 Apr 21. PMID: 20407806 Abstract Title: Cancer prevention by bovine lactoferrin: from animal studies to human trial. Abstract: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and, despite improved colonoscopic screening, CRC is a leading cause of death from cancer. Administration of bovine lactoferrin (bLF) …
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Influence of lactoferrin on the oxidant/antioxidant balance and molecular profile of hormone receptor-positive and -negative breast cancer cells.
PMID: Exp Oncol. 2017 Jul ;39(2):106-111. PMID: 29483488 Abstract Title: Influence of exogenous lactoferrin on the oxidant/antioxidant balance and molecular profile of hormone receptor-positive and -negative human breast cancer cells in vitro. Abstract: AIM: To investigate the mechanisms of cytotoxic activity and pro-/antioxidant effect of lactoferrin on hormone receptor-positive and receptor-negative breast cancer cells in …
New function of lactoferrin: protection against cancer development and metastasis.
PMID: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Dec ;37(12):1284-9. PMID: 23281388 Abstract Title: [New function of lactoferrin: protection against cancer development and metastasis]. Abstract: Lactoferrin (LF) is an 80 kD iron-binding glycoprotein that is most highly produced in human and bovine milk and is also widely distributed in mammals. Researches of …
Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice.
PMID: PLoS One. 2014 ;9(7):e103298. Epub 2014 Jul 24. PMID: 25057912 Abstract Title: Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice. Abstract: Nonresolving inflammatory processes affect all stages of carcinogenesis. Lactoferrin, a member of the transferrin family, is involved in the innate immune response and anti-inflammatory, anti-microbial, and anti-tumor activities. We previously found that lactoferrin …
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