Taylor Mercado

Inhalable lactoferrin-chondroitin sulfate nanocomposites would be a promising carrier for targeted drug delivery to lung cancer.

PMID: Nanomedicine (Lond). 2018 08 ;13(16):2015-2035. Epub 2018 Sep 7. PMID: 30191764 Abstract Title: Inhalable lactoferrin-chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma. Abstract: AIM: The use of inhalable nanomedicines can overcome the Enhanced permeation and retention effect (EPR)-associated drawbacks in lung cancer therapy via systemic nanomedicines.METHODS: We developed a …

Continue reading “Inhalable lactoferrin-chondroitin sulfate nanocomposites would be a promising carrier for targeted drug delivery to lung cancer.”

Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells.

PMID: Oncotarget. 2016 09 20 ;7(38):62144-62158. PMID: 27556694 Abstract Title: Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase. Abstract: Breast cancer is the most common type of cancer affecting women. Despite the good prognosis when detected early, significant challenges remain in the treatment of metastatic breast cancer. The …

Continue reading “Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells.”

Immunomodulatory lactoferrin in the regulation of apoptosis modulatory proteins in cancer.

PMID: Protein Pept Lett. 2013 Apr ;20(4):450-8. PMID: 23016584 Abstract Title: Immunomodulatory lactoferrin in the regulation of apoptosis modulatory proteins in cancer. Abstract: Lactoferrin (Lf), an iron binding ~80 kDa glycoprotein is a well characterized multifunctional protein found to be present in mammalian milk and in most exocrine secretions. Besides Lf's important physiological roles in …

Continue reading “Immunomodulatory lactoferrin in the regulation of apoptosis modulatory proteins in cancer.”

Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells.

PMID: Biochem Cell Biol. 2017 02 ;95(1):99-109. Epub 2016 Nov 30. PMID: 28169560 Abstract Title: Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways. Abstract: Lactoferrin (Lf) is an iron-binding glycoprotein that is present at high concentrations in milk. Bovine lactoferricin (LfcinB) is a peptide fragment …

Continue reading “Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells.”

Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro.

PMID: Exp Oncol. 2018 Oct ;40(3):184-189. PMID: 30285009 Abstract Title: Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro. Abstract: AIM: To investigate the biological effects of exogenous lactoferrin (LF) on phenotypic profile and invasiveness of human prostate cancer (PC) cells in vitro.MATERIALS AND METHODS: Human …

Continue reading “Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro.”

Role of lactoferrin and lactoferrin-derived peptides in oral and maxillofacial diseases.

PMID: Oral Dis. 2019 Apr ;25(3):652-669. Epub 2018 Jun 7. PMID: 29656422 Abstract Title: Role of lactoferrin and lactoferrin-derived peptides in oral and maxillofacial diseases. Abstract: The oral cavity harbors different taxonomic groups, the evolutionary coexistence of which develops the oral ecosystem. These resident microorganisms can alter the balance between the physiologic and pathologic conditions …

Continue reading “Role of lactoferrin and lactoferrin-derived peptides in oral and maxillofacial diseases.”

Lactoferrin and peptide-derivatives: antimicrobial agents with potential use in nonspecific immunity modulation.

PMID: Curr Pharm Des. 2018 ;24(10):1067-1078. PMID: 29589540 Abstract Title: Lactoferrin and Peptide-derivatives: Antimicrobial Agents with Potential Use in Nonspecific Immunity Modulation. Abstract: Lactoferrin (Lf) is a conserved cationic non-heme glycoprotein that is part of the innate immune defense system of mammals. Lf is present in colostrum, milk and mucosal sites, and it is also …

Continue reading “Lactoferrin and peptide-derivatives: antimicrobial agents with potential use in nonspecific immunity modulation.”

A review of lactoferrin and cancer in different cancer models.

PMID: Front Biosci (Schol Ed). 2011 Jun 1 ;3:1080-8. Epub 2011 Jun 1. PMID: 21622257 Abstract Title: Lactoferrin and cancer in different cancer models. Abstract: Lactoferrin (Lf) is a multifunctional protein and an essential element of innate immunity. Cancer is a major killer in today's world accounting for around 13% of all deaths according to …

Continue reading “A review of lactoferrin and cancer in different cancer models.”

The effect of bovine milk lactoferrin on human breast cancer cell lines.

PMID: J Dairy Sci. 2011 Jan ;94(1):66-76. PMID: 21183018 Abstract Title: The effect of bovine milk lactoferrin on human breast cancer cell lines. Abstract: The evidence that biologically active food components are key environmental factors affecting the incidence of many chronic diseases is overwhelming. However, the full extent of such components in our diet is …

Continue reading “The effect of bovine milk lactoferrin on human breast cancer cell lines.”

Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process.

PMID: BMC Immunol. 2012 Jun 18 ;13:32. Epub 2012 Jun 18. PMID: 22708778 Abstract Title: Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process by enhancing the expression of MIP-1α, MIP-2, KC, CX3CL1 and TGF-β in wounded tissue. Abstract: BACKGROUND: Continuous diabetes-associated complications are a major source of immune system exhaustion …

Continue reading “Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process.”