PMID: Evid Based Complement Alternat Med. 2019 ;2019:9610629. Epub 2019 Mar 17. PMID: 31007702 Abstract Title: Formononetin Enhances the Tumoricidal Effect of Everolimus in Breast Cancer MDA-MB-468 Cells by Suppressing the mTOR Pathway. Abstract: Background: Formononetin, an active ingredient isolated from the traditional Chinese medicinal herb, has anticancer and chemoresistance-reducing biological activities. We evaluated the …
Author Archives: Taylor Mercado
Formononetin may be a promising candidate for the treatment and prevention of osteoarthritis.
PMID: Inflammation. 2019 Aug ;42(4):1426-1440. PMID: 30937838 Abstract Title: Formononetin Antagonizes the Interleukin-1β-Induced Catabolic Effects Through Suppressing Inflammation in Primary Rat Chondrocytes. Abstract: In the present study, we demonstrated the anti-catabolic effects of formononetin, a phytoestrogen derived from herbal plants, against interleukin-1β (IL-1β)-induced severe catabolic effects in primary rat chondrocytes and articular cartilage. Formononetin did …
Formononetin inhibits lipopolysaccharide-induced release of high mobility group box.
PMID: PeerJ. 2018 ;6:e4208. Epub 2018 Jan 3. PMID: 29312829 Abstract Title: Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner. Abstract: Background: The release of high mobility group box 1 (HMGB1) induced by inflammatory signals acts as a cellular alarmin to trigger a chain of inflammatory …
Erucic acid derived from rosemary regulates differentiation of mesenchymal stem cells into osteoblasts instead of adipocytes via suppression of peroxisome proliferator-activated receptor γ transcriptional activity.
PMID: Phytother Res. 2020 Jan 27. Epub 2020 Jan 27. PMID: 31989712 Abstract Title: Erucic acid derived from rosemary regulates differentiation of mesenchymal stem cells into osteoblasts/adipocytes via suppression of peroxisome proliferator-activated receptorγ transcriptional activity. Abstract: Osteoporosis is associated with increase in fat tissue in bone marrow in humans. Mesenchymal stem cells in bone marrow …
Phytochemicals rosmarinic acid, ampelopsin, and amorfrutin-A can modulate Age-related phenotype of serially passaged human skin fibroblasts in vitro.
PMID: Front Genet. 2019 ;10:81. Epub 2019 Feb 21. PMID: 30847003 Abstract Title: Phytochemicals Rosmarinic Acid, Ampelopsin, and Amorfrutin-A Can Modulate Age-Related Phenotype of Serially Passaged Human Skin Fibroblasts. Abstract: One of the aims of the EU-funded Research and Innovation Action (RIA), titled"Ageing with Elegans"(AwE) is to enhance better understanding of the factors causing health …
Glycine tomentella hayata extract and its ingredient daidzin ameliorate cyclophosphamide-induced hemorrhagic cystitis and oxidative stress through the action of antioxidation, anti-fibrosis, and anti-inflammation.
PMID: Chin J Physiol. 2019 Sep-Oct;62(5):188-195. PMID: 31670282 Abstract Title: hayata extract and its ingredient daidzin ameliorate cyclophosphamide-induced hemorrhagic cystitis and oxidative stress through the action of antioxidation, anti-fibrosis, and anti-inflammation. Abstract: We explored the therapeutic potential of intragastric administration of traditional Chinese medicine Glycine tomentella Hayata (I-Tiao-Gung [ITG]) extract and its major component Daidzin …
Total Flavonoids from Leaves of Carya Cathayensis Ameliorate Renal Fibrosis via the miR-21/Smad7 Signaling Pathway.
PMID: Cell Physiol Biochem. 2018 ;49(4):1551-1563. Epub 2018 Sep 13. PMID: 30212825 Abstract Title: Total Flavonoids from Leaves of Carya Cathayensis Ameliorate Renal Fibrosis via the miR-21/Smad7 Signaling Pathway. Abstract: BACKGROUND/AIMS: Renal tubulointerstitial fibrosis is the most common pathway of progressive kidney injury, leading to end-stage renal disease. At present, no effective prophylactic treatment method …
Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21.
PMID: Toxicol Appl Pharmacol. 2018 11 1 ;358:35-42. Epub 2018 Sep 7. PMID: 30201452 Abstract Title: Baicalein represses TGF-β1-induced fibroblast differentiation through the inhibition of miR-21. Abstract: Fibroblast-to-myofibroblast differentiation is a highly important pathological characteristic of pulmonary fibrosis. In this study, we aimed to investigate the effects and mechanisms of baicalein on the differentiation of …
Total flavonoids from Smilax glabra Roxb blocks epithelial-mesenchymal transition and inhibits renal interstitial fibrosis by targeting miR-21/PTEN signaling.
PMID: J Cell Biochem. 2019 03 ;120(3):3861-3873. Epub 2018 Oct 10. PMID: 30304552 Abstract Title: Total flavonoids from Smilax glabra Roxb blocks epithelial-mesenchymal transition and inhibits renal interstitial fibrosis by targeting miR-21/PTEN signaling. Abstract: BACKGROUND: Smilax glabra Roxb, a traditional Chinese herb, has been widely used in folk medicine. The current study was performed to …
Astaxanthin improves stem cell potency via an increase in the proliferation of neural progenitor cells.
PMID: Int J Mol Sci. 2010 ;11(12):5109-19. Epub 2010 Dec 9. PMID: 21614195 Abstract Title: Astaxanthin improves stem cell potency via an increase in the proliferation of neural progenitor cells. Abstract: The present study was designed to investigate the question of whether or not astaxanthin improves stem cell potency via an increase in proliferation of …
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