PMID: Behav Pharmacol. 2019 12 ;30(8):700-711. PMID: 31703032 Abstract Title: Biochanin A protects against angiotensin II-induced damage of dopaminergic neurons in rats associated with the increased endophilin A2 expression. Abstract: The brain renin-angiotensin system plays a vital role in the modulation of the neuroinflammatory responses and the progression of dopaminergic (DA) degeneration. Angiotensin II (Ang …
Author Archives: Taylor Mercado
Biochanin A protected the brain against ischemic injury in rats by anti-oxidative and anti-inflammatory actions.
PMID: Med Sci Monit. 2019 Nov 26 ;25:8975-8983. Epub 2019 Nov 26. PMID: 31767824 Abstract Title: Biochanin A Provides Neuroprotection Against Cerebral Ischemia/Reperfusion Injury by Nrf2-Mediated Inhibition of Oxidative Stress and Inflammation Signaling Pathway in Rats. Abstract: BACKGROUND Oxidative stress and neuroinflammation are 2 pivotal mechanisms in the progression of cerebral ischemia/reperfusion injury. Biochanin A, …
Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway.
PMID: Acta Cir Bras. 2019 ;34(11):e201901104. Epub 2019 Dec 20. PMID: 31859817 Abstract Title: Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway. Abstract: PURPOSE: Myocardial ischemia/reperfusion (Ml/R) injury is a leading cause of damage in cardiac tissues, with high rates of mortality and disability. Biochanin A (BCA) is a main constituent of …
Black tea polyphenol theaflavin as promising antioxidant and potential copper chelator.
PMID: J Sci Food Agric. 2020 Feb 22. Epub 2020 Feb 22. PMID: 32086808 Abstract Title: Black tea polyphenol theaflavin as promising antioxidant and potential copper chelator. Abstract: BACKGROUND: In this work, we investigated the antioxidant and copper chelating abilities of theaflavin, a polyphenol responsible for astringency, color and sensation present in black tea. Using …
This systematic review and meta-analysis indicated that green tea significantly reduced the circulating levels of C-reactive protein.
PMID: Complement Ther Med. 2019 Oct ;46:210-216. Epub 2019 Aug 27. PMID: 31519281 Abstract Title: The effect of green tea on C-reactive protein and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Abstract: INTRODUCTION: The beneficial effects of green tea on regulating insulin sensitivity and preventing the …
EGCG protects SH-SY5Y cells against the cytotoxicity induced by lead and β-amyloid peptides by decreasing oxidative stress and inhibiting apoptosis.
PMID: J Biochem Mol Toxicol. 2019 Nov ;33(11):e22393. Epub 2019 Sep 13. PMID: 31518035 Abstract Title: Mitigative effects of epigallocatechin gallate in terms of diminishing apoptosis and oxidative stress generated by the combination of lead and amyloid peptides in human neuronal cells. Abstract: Environmental exposure to lead (Pb) is reported to associate with the development …
Butanol extract of Tinospora cordifolia ameliorates cognitive deficits associated with glutamate-induced excitotoxicity.
PMID: Neuromolecular Med. 2020 Mar ;22(1):81-99. Epub 2019 Oct 12. PMID: 31606849 Abstract Title: Butanol Extract of Tinospora cordifolia Ameliorates Cognitive Deficits Associated with Glutamate-Induced Excitotoxicity: A Mechanistic Study Using Hippocampal Neurons. Abstract: Overstimulation of glutamate receptors leads to development of excitotoxicity, which is implicated as final destructive pathway in neurodegenerative diseases. Development of alternative …
Tinospora cordifolia preserves pancreatic beta cells and enhances glucose uptake in adipocytes to regulate glucose metabolism in diabetic rats.
PMID: Phytother Res. 2019 Oct ;33(10):2765-2774. Epub 2019 Aug 5. PMID: 31385371 Abstract Title: Tinospora cordifolia preserves pancreatic beta cells and enhances glucose uptake in adipocytes to regulate glucose metabolism in diabetic rats. Abstract: The purpose of this study was to evaluate the pancreatic beta cell protective and glucose uptake enhancing effect of the water …
Tinospora cordifolia protects against inflammation associated anemia.
PMID: Sci Rep. 2019 Jul 29 ;9(1):10969. Epub 2019 Jul 29. PMID: 31358831 Abstract Title: Tinospora cordifolia protects against inflammation associated anemia by modulating inflammatory cytokines and hepcidin expression in male Wistar rats. Abstract: Systemic iron homeostasis dysregulation is primarily associated with inflammation- associated anemia (AI) due to hepcidin up-regulation. Tinospora cordifolia (TC) has shown …
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Tinospora cordifolia aqueous extract alleviates cyclophosphamide-induced immune suppression.
PMID: Curr Pharm Biotechnol. 2019 ;20(12):1055-1063. PMID: 31333126 Abstract Title: Tinospora cordifolia Aqueous Extract Alleviates Cyclophosphamide- Induced Immune Suppression, Toxicity and Systemic Candidiasis in Immunosuppressed Mice: In vivo Study in Comparison to Antifungal Drug Fluconazole. Abstract: OBJECTIVE: The present study was aimed to evaluate the effect of the aqueous extract of Tinospora cordifolia (AETC) against …
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