PMID: Food Funct. 2018 Sep 19 ;9(9):4926-4935. PMID: 30178798 Abstract Title: Silibinin decreases hepatic glucose production through the activation of gut-brain-liver axis in diabetic rats. Abstract: Silibinin, a flavonolignan derived from milk thistle (Silybum marianum), has been revealed to have a beneficial effect on improving diabetes-impaired glycemic control. However, the underlying mechanism is still unclear. …
Author Archives: Taylor Mercado
Inhibitory effect of silibinin on Amadori-albumin in diabetes mellitus: A multi-spectroscopic and biochemical approach.
PMID: Spectrochim Acta A Mol Biomol Spectrosc. 2019 Feb 15 ;209:217-222. Epub 2018 Oct 27. PMID: 30399482 Abstract Title: Inhibitory effect of silibinin on Amadori-albumin in diabetes mellitus: A multi-spectroscopic and biochemical approach. Abstract: Due to increased understanding of the damaging effects of glycation process, it is highly desirable to manage this process effectively either …
Silibinin is a promising candidate for the development of anti-virulence therapeutic agents to treat Streptococcus suis serotype 2 infections.
PMID: J Appl Microbiol. 2019 Feb ;126(2):435-442. Epub 2018 Nov 29. PMID: 30408277 Abstract Title: Silibinin attenuates Streptococcus suis serotype 2 virulence by targeting suilysin. Abstract: AIMS: To determine the antivirulence properties of silibinin against suilysin (SLY), a virulence factor of Streptococcus suis serotype 2 (SS2) that plays an important role in the pathogenesis of …
These data provides evidence to utilize the EGCG and silibinin combination as a novel approach to target tumor angiogenesis in the future.
PMID: ACS Omega. 2019 May 31 ;4(5):8421-8430. Epub 2019 May 13. PMID: 31459931 Abstract Title: Combination of Epigallocatechin-3-gallate and Silibinin: A Novel Approach for Targeting Both Tumor and Endothelial Cells. Abstract: Despite promising benefits, anti-angiogenic strategies have revealed several drawbacks, which necessitate development of novel approaches in cancer therapy strategies including non-small-cell lung cancer, as …
Silibinin activates the Nrf2-antioxidative pathways in pancreatic β-cells through regulation of ERα expression.
PMID: Biomol Ther (Seoul). 2019 Oct 25. Epub 2019 Oct 25. PMID: 31649209 Abstract Title: Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells. Abstract: Silibinin exhibits antidiabetic potential by preserving the mass and function of pancreaticβ-cells through up-regulation of estrogen receptor-α (ERα) expression. However, the underlying protective …
Silybin and paclitaxel in dextran-based nanoparticles are an effective treatment through chemotherapy sensitization and microenvironment modulation.
PMID: J Control Release. 2020 Feb 7 ;321:198-210. Epub 2020 Feb 7. PMID: 32044390 Abstract Title: Co-delivery of silybin and paclitaxel by dextran-based nanoparticles for effective anti-tumor treatment through chemotherapy sensitization and microenvironment modulation. Abstract: Modulation of tumor microenvironment (TME) has been indicated as an approach to improve efficacy of cancer therapy. Here, we proposed …
Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer’s disease.
PMID: Heliyon. 2020 Feb ;6(2):e03281. Epub 2020 Feb 3. PMID: 32055729 Abstract Title: Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease. Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function. Intracerebroventricular injection of streptozotocin (icv-STZ) has been used …
Microplastics impair the feeding performance of a Mediterranean habitat-forming coral.
PMID: Mar Environ Res. 2020 Mar ;155:104887. Epub 2020 Jan 22. PMID: 32072989 Abstract Title: Microplastics impair the feeding performance of a Mediterranean habitat-forming coral. Abstract: The impact of plastic debris, and in particular of microplastics (here referred as particles smaller than 5 mm) on aquatic environments has now become a topic of raising concern. Microplastics …
These findings suggest that silymarin attenuates the severity of acute pancreatitis.
PMID: Pancreas. 2020 Jan ;49(1):89-95. PMID: 31856083 Abstract Title: Silymarin Attenuates the Severity of Cerulein-Induced Acute Pancreatitis. Abstract: OBJECTIVES: In this study, we investigated the anti-inflammatory effects of silymarin on cerulein-induced acute pancreatitis (AP) in mice.METHODS: Cerulein (50μg/kg) was injected intraperitoneally once hourly for 6 hours to induce AP. To investigate the prophylactic effects of …
Silymarin showed a significant anti-proliferative and pro-apoptotic role in benign prostatic hyperplasia.
PMID: Pathol Oncol Res. 2020 Jan 4. Epub 2020 Jan 4. PMID: 31902118 Abstract Title: Modulatory Effect of Silymarin on Apoptosis in Testosterone -Induced Benign Prostatic Hyperplasia in Rats. Abstract: Benign prostatic hyperplasia (BPH) is considered a normal part of the aging process in men, and is characterized by an imbalance between cell proliferation and …
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