PMID: Int J Biol Macromol. 2020 Feb 7 ;149:1198-1206. Epub 2020 Feb 7. PMID: 32044368 Abstract Title: Silymarin encapsulated nanoliquid crystals for improved activity against beta amyloid induced cytotoxicity. Abstract: Silymarin (SLY) a natural Aβ aggregation inhibitor, antioxidant and act as neuroprotectant. In the present study, we have prepared nano liquid crystals (NLCs) of negatively …
Author Archives: Taylor Mercado
Silymarin inhibited DU145 cells by activating SLIT2 protein and suppressing expression of CXCR4.
PMID: Med Oncol. 2020 Feb 15 ;37(3):18. Epub 2020 Feb 15. PMID: 32062757 Abstract Title: Silymarin inhibited DU145 cells by activating SLIT2 protein and suppressing expression of CXCR4. Abstract: Among other cancers, prostate cancer is globally the second most rampant one with the incidence of 29.4% among men. SLIT2/ROBO1 signaling is very crucial pathway causally …
Silymarin, a popular dietary supplement shows anti-candida activity.
PMID: Antibiotics (Basel). 2019 Oct 31 ;8(4). Epub 2019 Oct 31. PMID: 31683548 Abstract Title: Silymarin, a Popular Dietary Supplement Shows Anti-Activity. Abstract: Silymarin is a complex of plant-derived compounds obtained from the seed shells of the milk thistle (. It is used in medicine primarily to protect the liver. The mixture contains mainly flavonolignans, …
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Silybin might have beneficial effects on ameliorating NAFLD and mediating high fat diet-induced change of gut microbiota composition.
PMID: Hepatol Res. 2020 Jan ;50(1):5-14. Epub 2020 Jan 5. PMID: 31661720 Abstract Title: Changes of gut microbiota during silybin-mediated treatment of high-fat diet-induced non-alcoholic fatty liver disease in mice. Abstract: AIM: Gut microbiota are involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Silybin (Sil), a naturally occurring hepatoprotective agent, is widely used …
Sustained release of silibinin-loaded chitosan nanoparticle induced apoptosis in glioma cells.
PMID: J Biomed Mater Res A. 2020 Mar ;108(3):458-469. Epub 2019 Nov 11. PMID: 31657514 Abstract Title: Sustained release of silibinin-loaded chitosan nanoparticle induced apoptosis in glioma cells. Abstract: In this study, a chitosan nanoparticle formulation was synthesized for loading silibinin as a sustained-release drug system to evaluate its effects on apoptosis in C6 glioma …
Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD model.
PMID: Biomed Pharmacother. 2020 Mar ;123:109721. Epub 2019 Dec 20. PMID: 31865143 Abstract Title: Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Abstract: Silybin shows good effects against obesity and metabolic syndrome, but the systemic modulation effect of silybin has not been fully revealed. This study aims to investigate …
Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway.
PMID: Hum Cell. 2020 Jan 18. Epub 2020 Jan 18. PMID: 31953678 Abstract Title: Silibinin enhances anti-renal fibrosis effect of MK-521 via downregulation of TGF-β signaling pathway. Abstract: Renal fibrosis is a common characteristic of chronic kidney disease (CKD), and it can lead to end-stage renal disease. It has been reported that silibinin or lisinopril …
Silibinin attenuates adipose tissue inflammation and reverses obesity and its complications in diet-induced obesity model.
PMID: BMC Pharmacol Toxicol. 2020 01 23 ;21(1):8. Epub 2020 Jan 23. PMID: 31973745 Abstract Title: Silibinin attenuates adipose tissue inflammation and reverses obesity and its complications in diet-induced obesity model in mice. Abstract: BACKGROUND: Obesity is a multifactorial chronic disease that comprises several pathological events, such as adipose hypertrophy, fatty liver and insulin resistance. …
Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells.
PMID: Arch Biochem Biophys. 2020 Jan 31:108284. Epub 2020 Jan 31. PMID: 32014401 Abstract Title: Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells. Abstract: We reported previously that higher doses (150-250 μM) of silibinin enhanced fission and inhibited fusion of mitochondria, accompanying apoptosis of double-positive breast cancer cell line …
Inhibition of urinary bladder cancer cell proliferation by silibinin.
PMID: Environ Mol Mutagen. 2020 Feb 20. Epub 2020 Feb 20. PMID: 32078183 Abstract Title: Inhibition of urinary bladder cancer cell proliferation by silibinin. Abstract: Silibinin, a natural compound extracted from milk thistle, has demonstrated antitumor properties in urinary bladder cancer cells; however the role of TP53 gene in these effects is unclear. In order …
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