PMID: Toxicol Appl Pharmacol. 2019 01 1 ;362:116-124. Epub 2018 Oct 24. PMID: 30365975 Abstract Title: The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells. Abstract: The capacity of cancer cells to resist detachment-induced apoptosis, i.e. anoikis, as well as anchorage-independent growth are crucial prerequisites for tumor …
Author Archives: Taylor Mercado
Isothiocyanate from broccoli, sulforaphane, and its properties.
PMID: J Med Food. 2019 Feb ;22(2):121-126. Epub 2018 Oct 27. PMID: 30372361 Abstract Title: Isothiocyanate from Broccoli, Sulforaphane, and Its Properties. Abstract: Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the …
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Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways.
PMID: J Asian Nat Prod Res. 2020 Apr ;22(4):386-396. Epub 2019 Mar 1. PMID: 30821482 Abstract Title: Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways. Abstract: The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural …
Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice.
PMID: Biol Reprod. 2019 Jul 1 ;101(1):223-234. PMID: 31004475 Abstract Title: Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice†. Abstract: Sulforaphane (SFN), a dietary isothiocyanate that is mainly found in cruciferous vegetables, possesses anti-oxidative and anticancer activity and modulates inflammation. However, little is known about the role of SFN in obesity-related male reproductive defects. The …
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These data suggest that consuming raw cruciferous vegetables may be associated with a lower odds of stomach cancer.
PMID: Nutr Cancer. 2020 ;72(1):52-61. Epub 2019 May 16. PMID: 31094219 Abstract Title: Cruciferous Vegetable Consumption and Stomach Cancer: A Case-Control Study. Abstract: To investigate the association between regular cruciferous vegetable intake and stomach cancer.A hospital-based, case-control study was conducted at Roswell Park Comprehensive Cancer Center in Buffalo, NY, which included 292 stomach cancer patients …
Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model.
PMID: Exp Hematol. 2019 09 ;77:51-60.e1. Epub 2019 Aug 9. PMID: 31404577 Abstract Title: Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model. Abstract: Sickle cell disease (SCD) is a recessively inherited blood disorder caused by abnormalβ-globin production. The β-globin mutation changes erythrocyte morphology into a sickle …
This study suggests that vegetables may reduce the risk of cataracts in men.
PMID: J Epidemiol. 2019 Dec 14. Epub 2019 Dec 14. PMID: 31839643 Abstract Title: Intake of vegetables and fruits and the risk of cataract incidence in a Japanese population: the Japan Public Health Center-based Prospective Study. Abstract: BACKGROUND: Although the consumption of vegetables and fruits is reported to influence the risk of cataract, no prospective …
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Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.
PMID: Carcinogenesis. 2003 Oct ;24(10):1665-70. Epub 2003 Aug 1. PMID: 12896904 Abstract Title: Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Abstract: We have shown previously that allyl isothiocyanate (AITC), a constituent of cruciferous vegetables, significantly inhibits survival of PC-3 and LNCaP human prostate cancer cells …
These results demonstrate the potential of allyl isothiocyanate and N-acetylcysteine- allyl isothiocyanate as chemopreventive agents.
PMID: Exp Biol Med (Maywood). 2006 Apr ;231(4):421-30. PMID: 16565438 Abstract Title: Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells. Abstract: Cruciferous vegetables contain a series of relatively unique secondary metabolites of amino acids, called glucosinolates. Sinigrin, the predominant aliphatic …
Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions.
PMID: Eur J Pharmacol. 2007 Apr 30 ;561(1-3):172-81. Epub 2007 Jan 27. PMID: 17346695 Abstract Title: Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions in rats. Abstract: Allyl isothiocyanate is well known to be a principal pungent constituent of horseradish and an agonist for transient receptor potential (TRP) A1. Ally isothiocyanate markedly …
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