PMID: Neurobiol Dis. 2006 May ;22(2):421-34. Epub 2006 Feb 9. PMID: 16480889 Abstract Title: Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Abstract: In the present study, an attempt has been made to explore the neuroprotective and neuroreparative (neurorescue) effect of black tea extract (BTE) in 6-hydroxydopamine (6-OHDA)-lesioned …
Author Archives: Taylor Mercado
Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.
PMID: Curr Alzheimer Res. 2007 Sep ;4(4):403-11. PMID: 17908043 Abstract Title: Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG. Abstract: Accumulation of iron at sites where neurons degenerate in Parkinson's disease (PD) and Alzheimer's disease (AD) is thought to have a …
Epigallocatechin gallate inhibits nitric oxide-induced apoptosis in rat PC12 cells.
PMID: Neurosci Lett. 2007 Jan 16 ;411(3):222-7. Epub 2006 Nov 20. PMID: 17116366 Abstract Title: Epigallocatechin gallate inhibits nitric oxide-induced apoptosis in rat PC12 cells. Abstract: Nitric oxide (NO) is associated with many pathophysiology of the central nervous system including brain ischemia, neurodegeneration and inflammation. Epigallocatechin gallate (EGCG) is a major compound of green tea …
Orally administered EGCG attenuates injury to the retina caused by ischemia/reperfusion where caspases were activated.
PMID: Brain Res. 2008 Mar 10 ;1198:141-52. Epub 2007 Dec 15. PMID: 18255049 Abstract Title: Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro. Abstract: The aim of this study was to provide support for epigallocatechin gallate (EGCG), a component of green tea, to be considered in the context …
Review on the neuroprotective effects of green tea polyphenols for the treatment of neurodegenerative diseases.
PMID: Wei Sheng Yan Jiu. 2010 Jan ;39(1):123-6. PMID: 20364607 Abstract Title: [Review on the neuroprotective effects of green tea polyphenols for the treatment of neurodegenerative diseases]. Abstract: Considering the multi-etiological characters of neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease, the current pharmacological approaches using drugs oriented towards a single molecular target possess …
Both in vitro and in vivo studies demonstrate that oral administration of EGCG may have significant beneficial effects in Parkinson’s patients treated with L-DOPA/carbidopa by exerting a modest inhibition of L-DOPA methylation and strong neuroprotection.
PMID: PLoS One. 2010 Aug 5 ;5(8):e11951. Epub 2010 Aug 5. PMID: 20700524 Abstract Title: Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies. Abstract: BACKGROUND: A combination of levodopa (L-DOPA) and carbidopa is the most commonly-used treatment for symptom management in Parkinson's disease. Studies have shown …
Evidence suggests quercetin protects against cholesterol-induced neurotoxicity.
PMID: J Pathol. 2010 Dec ;222(4):329-34. PMID: 20922714 Abstract Title: AMP-activated protein kinase: 'a cup of tea' against cholesterol-induced neurotoxicity. Abstract: Disturbances in brain cholesterol metabolism have been linked to Alzheimer's disease (AD) pathology. A high-cholesterol diet increases fibrillar amyloidβ peptide (Aβ) deposition, inflammation, and apoptosis that eventually results in neurodegeneration and learning and memory …
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Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson’s disease.
PMID: Brain Res. 2012 Jan 18 ;1433:104-13. Epub 2011 Nov 13. PMID: 22138428 Abstract Title: Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease. Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by loss of dopominergic neurons in substantia nigra pars compacta, and can be experimentally induced …
Fermentation with L. plantarum potentially improves the anti-inflammatory activities of mustard leaf.
PMID: Foods. 2020 Feb 12 ;9(2). Epub 2020 Feb 12. PMID: 32059406 Abstract Title: Enhancement of the Anti-Inflammatory Effect of Mustard Kimchi on RAW 264.7 Macrophages by theFermentation-Mediated Generation of Phenolic Compound Derivatives. Abstract: Mustard leaf kimchi contains numerous functional compounds that have various health benefits. However, the underlying mechanisms of their anti-inflammatory effects are …
Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols.
PMID: Front Biosci (Schol Ed). 2012 Jan 1 ;4:581-98. Epub 2012 Jan 1. PMID: 22202078 Abstract Title: Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols. Abstract: Mounting evidence suggests that lifestyle factors, especially nutrition are essential factor for healthy ageing. However, as a result of the increase in life expectance, neurodegenerative diseases …
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