PMID: Curr Pharm Des. 2012 ;18(1):4-14. PMID: 22211685 Abstract Title: Protective effects of chronic green tea consumption on age-related neurodegeneration. Abstract: Dietary antioxidant compounds, due to their pivotal role in the modulation of cellular redox mechanisms, are gaining attention of researchers in the field of brain aging and related degenerative diseases. In this perspective, green …
Author Archives: Taylor Mercado
Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson’s disease.
PMID: Neuroscience. 2012 Aug 30 ;218:257-67. Epub 2012 May 23. PMID: 22634505 Abstract Title: Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease. Abstract: Evidence from clinical and experimental studies indicates that degeneration of nigrostriatal dopaminergic neurons is a pathological hallmark of Parkinson's disease (PD). …
Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro.
PMID: Biochim Biophys Acta. 2012 Nov ;1818(11):2502-10. Epub 2012 May 23. PMID: 22634381 Abstract Title: Polyphenolic compounds are novel protective agents against lipid membrane damage byα-synuclein aggregates in vitro. Abstract: Cumulative evidence now suggests that the abnormal aggregation of the proteinα-synuclein (αS) is a critical factor in triggering neurodegeneration in Parkinson's disease (PD). In particular, …
This excerpt discusses the potential therapeutic role of botanical phenolics in neurodegenerative disease.
PMID: . PMID: 22593921 Abstract Title: Botanical Phenolics and Neurodegeneration. Abstract: Many vegetables, fruits, grains, roots, flowers, and seeds are rich in polyphenolic compounds, and they offer beneficial effects in protecting against diseases involving oxidative stress, such as cancers and cardiovascular and neurodegenerative diseases. Although the mechanisms through which these compounds exert beneficial effects are …
This review elaborates on the impact of nutritional supplementation on brain function and provides a compilation of epidemiology, clinical and animal studies with green tea polyphenols in age-associated cognitve decline and neurodegenerative diseases.
PMID: Recent Pat CNS Drug Discov. 2012 Dec ;7(3):205-17. PMID: 22742421 Abstract Title: In the rush for green gold: Can green tea delay age-progressive brain neurodegeneration? Abstract: It is evident that brain aging engages changes in biological systems linked to synaptic function and cell metabolism and in the capacity to cope with different stresses that …
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
PMID: Brain Res. 2013 Feb 25 ;1497:1-14. Epub 2012 Dec 1. PMID: 23206800 Abstract Title: Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. Abstract: Levodopa (L-DOPA) is widely used for symptomatic management in Parkinson's disease. We recently showed that (-)-epigallocatechin-3-gallate, a tea polyphenol, not only inhibits L-DOPA methylation, but also protects against …
This review discusses the neuroprotective action of gallic acid and its derivatives.
PMID: Curr Pharm Biotechnol. 2014 ;15(4):362-72. PMID: 24938889 Abstract Title: Polyphenols: well beyond the antioxidant capacity: gallic acid and related compounds as neuroprotective agents: you are what you eat! Abstract: Gallic acid (3,4,5-trihydroxybenzoic acid) is a phenolic acid widely distributed in many different families of higher plants, both in free state, and as a part …
(-)-Epigallocatechin-3-gallate modulates spinal cord neuronal degeneration by enhancing growth-associated protein 43, B-cell lymphoma 2, and decreasing B-cell lymphoma 2-associated x protein expression after sciatic nerve crush injury.
PMID: J Neurotrauma. 2015 Feb 1 ;32(3):170-84. Epub 2014 Nov 10. PMID: 25025489 Abstract Title: (-)-Epigallocatechin-3-gallate modulates spinal cord neuronal degeneration by enhancing growth-associated protein 43, B-cell lymphoma 2, and decreasing B-cell lymphoma 2-associated x protein expression after sciatic nerve crush injury. Abstract: Our previous studies have established that (-)-epigallocatechin-3-gallate (EGCG) has both neuroprotective and …
Protective role of glutamine against cadmium-induced testicular dysfunction.
PMID: Life Sci. 2020 Feb 1 ;242:117250. Epub 2019 Dec 31. PMID: 31899225 Abstract Title: Protective role of glutamine against cadmium-induced testicular dysfunction in Wistar rats: Involvement of G6PD activity. Abstract: BACKGROUND: Endocrine disruptor such as cadmium has been widely reported to cause testicular toxicity, which contributes to recent decline in male fertility worldwide. Glutamine, …
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Kiwifruits rich in antioxidants like phenolics and vitamin C have good potential as functional materials in neuroprotective applications.
PMID: J Microbiol Biotechnol. 2020 Feb 18. Epub 2020 Feb 18. PMID: 32066217 Abstract Title: Phenolic Profiles of Hardy Kiwifruits and Their Neuroprotective Effects on PC-12 and SH-SY5Y Cells against Oxidative Stress. Abstract: Hardy kiwifruits (Planch.) have high amounts of antioxidants, including ascorbic acid (vitamin C) and phenolics. The anti-cholinesterase activity and neuroprotective effects of …
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