PMID: Mol Nutr Food Res. 2020 Feb 12:e1900876. Epub 2020 Feb 12. PMID: 32050056 Abstract Title: Dietary Supplementation of Black Rice Anthocyanin Extract Regulates Cholesterol Metabolism and Improves Gut Microbiota Dysbiosis in C57BL/6J Mice Fed a High-Fat and Cholesterol Diet. Abstract: SCOPE: This study explored the beneficial effects of dietary supplementation of black rice anthocyanin …
Author Archives: Taylor Mercado
Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells.
PMID: Sci Rep. 2019 Aug 22 ;9(1):12277. Epub 2019 Aug 22. PMID: 31439870 Abstract Title: Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells. Abstract: Tumor microenvironment favors tumor cells to promote their growth and metastasis such as migration, invasion, and angiogenesis. IL-1β, one of the inflammatory cytokines …
Protective effect of celastrol for burn-induced acute lung injury.
PMID: Int J Clin Exp Pathol. 2019 ;12(2):576-583. Epub 2019 Feb 1. PMID: 31933862 Abstract Title: Protective effect of celastrol for burn-induced acute lung injury in rats. Abstract: Celastrol (CEL) was shown to display anti-inflammatory properties, and played an important role in anti-apoptosis. There were inflammation mediated by cytokines and apoptosis distinctly in the progression …
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Simultaneous administration of metformin and celastrol appears to have additive benefits in the treatment of liver cancer compared to cela monotherapy.
PMID: Cancer Chemother Pharmacol. 2020 Feb ;85(2):331-343. Epub 2020 Jan 27. PMID: 31989218 Abstract Title: Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis. Abstract: One promising strategy for minimizing chemotherapeutic resistance in hepatocellular carcinoma (HCC) is the use of effective chemosensitizers. We studied …
Celastrol alleviates gamma irradiation-induced damage by modulating diverse inflammatory mediators.
PMID: Int J Mol Sci. 2020 Feb 6 ;21(3). Epub 2020 Feb 6. PMID: 32041250 Abstract Title: Celastrol Alleviates Gamma Irradiation-Induced Damage by Modulating Diverse Inflammatory Mediators. Abstract: The present study aimed to explore the possible radioprotective effects of celastrol and relevant molecular mechanisms in an in vitro cell and in vivo mouse models exposed …
Complementary and Alternative Medicine (CAM): Wikipedia vs the Science
Science is not about good and bad, it is about proven and not proven
Neorogioltriol and related diterpenes from the red alga Laurencia inhibit inflammatory bowel disease.
PMID: Mar Drugs. 2019 Feb 2 ;17(2). Epub 2019 Feb 2. PMID: 30717366 Abstract Title: Neorogioltriol and Related Diterpenes from the Red AlgaInhibit Inflammatory Bowel Disease in Mice by Suppressing M1 and Promoting M2-Like Macrophage Responses. Abstract: Macrophages are central mediators of inflammation, orchestrating the inflammatory response through the production of cytokines and nitric oxide. …
Red alga polysaccharides attenuate angiotensin II-induced inflammation in coronary endothelial cells.
PMID: Biochem Biophys Res Commun. 2018 06 12 ;500(4):944-951. Epub 2018 May 2. PMID: 29705698 Abstract Title: Red alga polysaccharides attenuate angiotensin II-induced inflammation in coronary endothelial cells. Abstract: The pro-inflammatory vasoconstrictor Angiotensin II can cause endothelial dysfunction and is considered to be one of the mediators of atherosclerosis. Our former results demonstrated that polysaccharides …
Rare acetogenins with anti-inflammatory effect from the red alga Laurencia obtusa.
PMID: Molecules. 2019 Jan 29 ;24(3). Epub 2019 Jan 29. PMID: 30699968 Abstract Title: Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga. Abstract: Three new rare Cacetogenins (enyne derivatives⁻) were isolated from the organic extract obtained from the red alga, collected from the Red Sea. The chemical structures of the isolated compounds were established …
Inhibitory effects of collismycin C and pyrisulfoxin A on particulate matter-induced pulmonary injury.
PMID: Phytomedicine. 2019 Sep ;62:152939. Epub 2019 Apr 23. PMID: 31100678 Abstract Title: Inhibitory effects of collismycin C and pyrisulfoxin A on particulate matter-induced pulmonary injury. Abstract: BACKGROUND: Inhalation of fine particulate matter (PM) is associated with elevated pulmonary injury caused by the loss of vascular barrier integrity. Marine microbial natural products isolated from microbial …
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