PMID: ACS Omega. 2019 Jul 31 ;4(7):12259-12270. Epub 2019 Jul 17. PMID: 31460342 Abstract Title: Anti-Alzheimer's Disease Activity of Bromophenols from a Red Alga,(Harvey) Yamada. Abstract: (Harvey) Yamada is a red alga with a myriad of bromophenols accompanied by a diverse array of biological activities. The main purpose of the present study was to characterize …
Author Archives: Taylor Mercado
A new antitumor arabinopyranoside from Laurencia majuscula induces G2/M cell cycle arrest.
PMID: Phytother Res. 2010 Oct ;24(10):1447-50. PMID: 20878692 Abstract Title: A new antitumor arabinopyranoside from Laurencia majuscula induces G2/M cell cycle arrest. Abstract: A new arabinopyranoside was isolated from the alga Laurencia majuscula (Harvey) Lucas, collected from the Xisha Islands in the South China Sea. Its structure was elucidated as hexadecyl-1-O-α-L-arabinopyranoside by spectroscopic analysis. It …
Antimicrobial, antioxidant and anticancer activities of Laurencia catarinensis, Laurencia majuscula and Padina pavonica extracts.
PMID: Saudi Pharm J. 2018 Jan ;26(1):44-52. Epub 2017 Nov 10. PMID: 29379332 Abstract Title: Antimicrobial, antioxidant and anticancer activities of,andextracts. Abstract: The antimicrobial, antioxidant, and anticancer activities of ethanolic extract ofwere determined. The highest antibacterial activity; 23.40 ± 0.58 mm (00.98 µg/ml) and 22.60 ± 2.10 mm (03.90 µg/ml) were obtained againstbyand, respectively. However,showed excellent antibacterial activity against(21.7 ± 1.5 mm; 1.95 µg/ml),(21.7 ± 0.58 mm; 1.95 µg/ml),(20.7 ± 1.2 mm; 1.95 µg/ml) and(20.1 ± 1.2 mm; …
Pro-apoptotic activity of Padina pavonica extract on human osteosarcoma cells.
PMID: Mar Drugs. 2018 Dec 13 ;16(12). Epub 2018 Dec 13. PMID: 30551628 Abstract Title: Pro-Apoptotic Activity of French PolynesianExtract on Human Osteosarcoma Cells. Abstract: Recently, seaweeds and their extracts have attracted great interest in the pharmaceutical industry as a source of bioactive compounds. Studies have demonstrated the cytotoxic activity of macroalgae towards different types …
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Consumption of terpenoids-rich Padina pavonia extract attenuates hyperglycemia, insulin resistance and oxidative stress.
PMID: Antioxidants (Basel). 2019 Dec 26 ;9(1). Epub 2019 Dec 26. PMID: 31887984 Abstract Title: Consumption of Terpenoids-RichExtract Attenuates Hyperglycemia, Insulin Resistance and Oxidative Stress, and Upregulates PPARγ in a Rat Model of Type 2 Diabetes. Abstract: Seaweeds are rich in structurally diverse bioactive compounds with promising therapeutic effects. This study aimed to isolate and …
Celastrol may inhibit colon cancer cell proliferation by negatively regulating miR-21 and the PI3K/AKT/GSK-3β pathway.
PMID: Int J Clin Exp Pathol. 2019 ;12(3):808-816. Epub 2019 Mar 1. PMID: 31933888 Abstract Title: Celastrol inhibits colon cancer cell proliferation by downregulating miR-21 and PI3K/AKT/GSK-3β pathway. Abstract: Celastrol is a traditional Chinese medicine, that is derived from Tripterygium wilfordii. It has been proposed to offer anti-tumor potential. MicroRNAs also play important roles in …
Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway
PMID: Cancer Med. 2020 Jan ;9(2):783-796. Epub 2019 Nov 26. PMID: 31957323 Abstract Title: Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway. Abstract: AIM: Cholangiocarcinoma is a malignant tumor originating from bile duct epithelium. Currently, the treatment strategy is very limited and the prognosis is poor. Recent …
Celastrol may help to prevent and treat Parkinson’s disease.
PMID: Antioxidants (Basel). 2019 Dec 31 ;9(1). Epub 2019 Dec 31. PMID: 31906147 Abstract Title: Celastrol Inhibits Dopaminergic Neuronal Death of Parkinson's Disease through Activating Mitophagy. Abstract: Parkinson's disease (PD) is a neurodegenerative disease, which is associated with mitochondrial dysfunction and abnormal protein accumulation. No treatment can stop or slow PD. Autophagy inhibits neuronal death …
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Melatonin prevents TGF-β1-stimulated transdifferentiation of fibroblasts to myofibroblasts.
PMID: Antioxidants (Basel). 2020 Jan 1 ;9(1). Epub 2020 Jan 1. PMID: 31906396 Abstract Title: Melatonin Prevents Transforming Growth Factor-β1-Stimulated Transdifferentiation of Renal Interstitial Fibroblasts to Myofibroblasts by Suppressing Reactive Oxygen Species-Dependent Mechanisms. Abstract: Accumulating evidence suggests that the pineal hormone melatonin displays protective effects against renal fibrosis, but the mechanisms remain poorly understood. Here, …
Curcumin is a natural product, which can be a therapeutic option in a variety of retinal diseases due to its pleiotropic properties.
PMID: Antioxidants (Basel). 2020 Jan 6 ;9(1). Epub 2020 Jan 6. PMID: 31935797 Abstract Title: Curcumin as a Therapeutic Option in Retinal Diseases. Abstract: The retina is subjected to oxidative stress due to its high vascularization, long time light exposition and a high density of mitochondria. Oxidative stress can lead to pathological processes, like cell …
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