n/a PMID: J Nutr Biochem. 2020 Jan ;75:108261. Epub 2019 Oct 27. PMID: 31710934 Abstract Title: Piperine regulates glycogen synthase kinase-3β-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model. Abstract: Aging-related cholinergic dysfunction, extensive neuroinflammation and oxidative stress in brain are predominant pathogenic factors for dementia. In the present study, we aimed to …
Author Archives: Taylor Mercado
These results indicate that compounds from Piper nigrum have potential anti-inflammatory effects.
PMID: J Agric Food Chem. 2020 Feb 7. Epub 2020 Feb 7. PMID: 32031370 Abstract Title: Alkaloids from Black Pepper (Piper nigrum L.) Exhibit Anti-inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-κB Pathway. Abstract: Black Pepper (Piper nigrum L.) has been commonly utilized in food preparation as well as traditional medicine in several …
Piper Nigrum extract improves OVA-induced nasal epithelial barrier dysfunction via activating Nrf2/HO-1 signaling.
PMID: Cell Immunol. 2019 Dec 30:104035. Epub 2019 Dec 30. PMID: 32051090 Abstract Title: Piper Nigrum extract improves OVA-induced nasal epithelial barrier dysfunction via activating Nrf2/HO-1 signaling. Abstract: BACKGROUND: Piper nigrum L. (Piperaceae) is commonly used as a spice and traditional medicine in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, …
Antioxidant and anti-glycation potential of Piper nigrum.
PMID: Food Chem. 2020 Jan 23 ;316:126280. Epub 2020 Jan 23. PMID: 32058192 Abstract Title: Antioxidant and anti-glycation potential of green pepper (Piper nigrum): Optimization ofβ-cyclodextrin-based extraction by response surface methodology. Abstract: Green pepper (Piper nigrum) presents high levels of functional compounds, with antioxidant and anti-glycation properties. Thus, the optimization of theβ-cyclodextrin-based extraction of functional …
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Piplartine suppresses proliferation and invasion of hepatocellular carcinoma.
PMID: Cancer Lett. 2019 Sep 28 ;460:119-127. Epub 2019 Jun 14. PMID: 31207322 Abstract Title: Piplartine suppresses proliferation and invasion of hepatocellular carcinoma by LINC01391-modulated Wnt/β-catenin pathway inactivation through ICAT. Abstract: Although piplartine is regarded as an anticancer agent, the relationship between long noncoding RNAs (lncRNAs), which are involved in various diseases (e.g., tumors) and …
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Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation.
PMID: Cell Death Dis. 2020 Jan 10 ;11(1):21. Epub 2020 Jan 10. PMID: 31924750 Abstract Title: Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation. Abstract: Psoriasis is an autoimmune skin disease, where chronic immune responses due to exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes apoptosis plays …
Antiparasitic activity of piplartine in a mouse model of schistosomiasis.
PMID: Acta Trop. 2020 Jan 18:105350. Epub 2020 Jan 18. PMID: 31962096 Abstract Title: Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis. Abstract: Schistosomiasis is one of the most important parasitic infections in terms of its negative effects on public health and economics. Since praziquantel is currently the only drug available to …
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Piperlongumine produced potent antitumor properties in osteosarcoma cells.
PMID: Toxicol In Vitro. 2020 Jan 24 ;65:104775. Epub 2020 Jan 24. PMID: 31987842 Abstract Title: Piperlongumine induces apoptosis and G/M phase arrest in human osteosarcoma cells by regulating ROS/PI3K/Akt pathway. Abstract: Previous research has reported that piperlongumine exerts antitumor properties on several types of tumor cells. However, its effect on osteosarcoma cells remains unknown. …
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Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury.
PMID: Pulm Pharmacol Ther. 2020 Jan 24 ;61:101896. Epub 2020 Jan 24. PMID: 31988027 Abstract Title: Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury. Abstract: Chronic obstructive pulmonary disease (COPD) is related to smoking and anti-inflammatory therapy is indicated. Among the mediators with anti-inflammatory properties, we highlight piperlongumine (PL), an …
Inhibitory effect of nordihydroguaiaretic acid on helicobacter pylori-associated gastric carcinogenesis.
PMID: Cancer Sci. 2007 Nov ;98(11):1689-95. PMID: 17894552 Abstract Title: Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils. Abstract: Recent epidemiological studies have demonstrated that consumption of certain natural products can lower cancer risk in humans. For example, plant-derived lignans have been shown to exert chemopreventive effects …
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