Author Archives: Taylor Mercado

PMID:  Br J Cancer. 2002 Apr 8 ;86(7):1188-96. PMID: 11953870 Abstract Title:  Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells. Abstract:  Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of …

Continue reading “Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells.”

PMID:  Cancer Detect Prev. 2005 ;29(3):276-85. Epub 2005 Feb 17. PMID: 15936596 Abstract Title:  Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid. Abstract:  The aim of the study was to investigate the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on histone deacetylase-mediated proliferation inhibition. In the …

Continue reading “Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid.”

PMID:  Mutat Res. 1991 Nov ;261(3):153-62. PMID: 1719406 Abstract Title:  Antimutagenic and antitumorigenic activities of nordihydroguaiaretic acid. Abstract:  Nordihydroguaiaretic acid (NDGA), which occurs in the resinous exudates of many plants is used as an antioxidant in fats and oils. In this study we show that NDGA inhibited the mutagenicity of methyl methanesulfonate, benzo[a]pyrene (BP), 2-aminofluorene, …

Continue reading “Antimutagenic and antitumorigenic activities of nordihydroguaiaretic acid.”

PMID:  Intervirology. 2005 ;48(5):336-40. PMID: 15956802 Abstract Title:  Inhibition of influenza-virus-induced apoptosis in chorion cells of human fetal membranes by nordihydroguaiaretic Acid. Abstract:  OBJECTIVES: It has been postulated that the pathogenesis of influenza virus infection involves not only the virus-proliferation-mediated apoptotic cell death in infected cells, but also a direct reactive oxygen species (ROS)-induced cellular …

Continue reading “Inhibition of influenza-virus-induced apoptosis in chorion cells of human fetal membranes by nordihydroguaiaretic acid.”

PMID:  Clin Cancer Res. 2005 Jun 15 ;11(12):4601-9. PMID: 15958646 Abstract Title:  Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Abstract:  PURPOSE: We have previously shown that the transcriptional inhibitor tetra-O-methyl nordihydroguaiaretic acid (M4N) induces growth arrest in tumor cells and exhibits tumoricidal activity when injected intratumorally into tumor cell …

Continue reading “Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors.”

PMID:  Zhonghua Bing Li Xue Za Zhi. 2000 Feb ;29(1):30-3. PMID: 11866889 Abstract Title:  [The effect of nordihydroguaiaretic acid on endothelial cell migration induced by glioma cells]. Abstract:  OBJECTIVE: To investigate the effect of nordihydroguaiaretic acid (NDGA) on the migration of endothelial cells (ECs) induced by glioma cells (GCs) in vitro.METHODS: Cells of human umbilical …

Continue reading “The effect of nordihydroguaiaretic acid on endothelial cell migration induced by glioma cells.”

PMID:  Leuk Lymphoma. 2007 Apr ;48(4):774-85. PMID: 17454637 Abstract Title:  Tetra-O-methyl nordihydroguaiaretic acid inhibits growth and induces death of leukemia cells independent of Cdc2 and survivin. Abstract:  Tetra-O-methyl nordihydroguaiaretic acid (M4N) was shown to induce G2 arrest and suppress human xenograft tumor growth by inhibiting Cdc2 and survivin. We examined the effect of M4N on …

Continue reading “Tetra-O-methyl nordihydroguaiaretic acid inhibits growth and induces death of leukemia cells independent of Cdc2 and survivin.”

PMID:  Hepatology. 2011 Dec ;54(6):1936-46. PMID: 21858850 Abstract Title:  Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus. Abstract:  UNLABELLED: Hepatitis C virus (HCV) relies on host lipid metabolic pathways for its replication, assembly, secretion, and entry. HCV induces de novo lipogenesis, inhibitsβ-oxidation, and lipoprotein export resulting in a lipid-enriched cellular …

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PMID:  Cancer Res. 2001 Jul 15 ;61(14):5499-504. PMID: 11454698 Abstract Title:  Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo. Abstract:  The transcription inhibitor tetra-O-methyl nordihydroguaiaretic acid (M4N) was found to arrest the proliferation of C3, C33a, CEM-T4, and TC-1 cells in culture at the G2 stage of the …

Continue reading “Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo.”

PMID:  Brain Res. 1994 Aug 15 ;654(1):171-6. PMID: 7982093 Abstract Title:  Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation. Abstract:  Recent findings indicate that amyloid beta-peptide (A beta) can be neurotoxic by a mechanism involving an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) and the …

Continue reading “Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation.”