PMID: J Neurochem. 2002 May ;81(3):434-40. PMID: 12065652 Abstract Title: Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro. Abstract: Inhibition of the accumulation of amyloid beta-peptide (Abeta) and the formation of beta-amyloid fibrils (fAbeta) from Abeta, as well as the degradation of pre-formed fAbeta in the CNS would be attractive therapeutic objectives …
Author Archives: Taylor Mercado
Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation.
PMID: J Neurosurg. 1989 Oct ;71(4):551-7. PMID: 2507753 Abstract Title: Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation. Abstract: When cultured malignant cells derived from rat gliomas (C6 and 9L) and human gliomas (A-172 and T98G) were treated for 4 hours with 1 to 80 microns nordihydroguaiaretic acid (NDGA) or 5,8,11,14-eicosatetraynoic …
Intranasal glyphosate-based herbicide administration alters the redox balance and the cholinergic system in the mouse brain.
PMID: Neurotoxicology. 2020 Jan 25 ;77:205-215. Epub 2020 Jan 25. PMID: 31991143 Abstract Title: Intranasal glyphosate-based herbicide administration alters the redox balance and the cholinergic system in the mouse brain. Abstract: Pesticide exposure is associated with cognitive and psychomotor disorders. Glyphosate-based herbicides (GlyBH) are among the most used agrochemicals, and inhalation of GlyBH sprays may …
Glyphosate exposure induces inflammatory responses in the small intestine and alters gut microbial composition in rats.
PMID: Environ Pollut. 2020 Feb 3 ;261:114129. Epub 2020 Feb 3. PMID: 32045792 Abstract Title: Glyphosate exposure induces inflammatory responses in the small intestine and alters gut microbial composition in rats. Abstract: Glyphosate is the most popular herbicide used worldwide. This study aimed to investigate the adverse effects of glyphosate on the small intestine and …
These results indicate that NDGA pretreatment is renoprotective in cisplatin-induced nephrotoxicity.
PMID: Immunopharmacol Immunotoxicol. 2019 Feb ;41(1):68-75. Epub 2019 Jan 3. PMID: 30604648 Abstract Title: Differential effect of NDGA on cisplatin-induced nephrotoxicity in Spargue-Dawley rats. Abstract: Nephrotoxicity is a highly manifested complication in cancer patients undergoing cisplatin therapy. Oxidative stress, nitrosative stress, and inflammation are the major patho-mechanisms of cisplatin-induced nephrotoxicity.The purpose of this study was …
Nordihydroguaiaretic acid prevents glycation induced structural alterations and aggregation of albumin.
PMID: Int J Biol Macromol. 2019 Feb 1 ;122:479-484. Epub 2018 Oct 26. PMID: 30416092 Abstract Title: Nordihydroguaiaretic acid prevents glycation induced structural alterations and aggregation of albumin. Abstract: This study demonstrates the antiglycation activity of Nordihydroguaiaretic acid, a lignin from the creosote bush (Larrea tridentate), which has also been proven to assist in the …
Diabetic encephalopathy: beneficial effects of supplementation with fatty acids ω3 and nordihydroguaiaretic acid.
PMID: Lipids Health Dis. 2019 Feb 8 ;18(1):43. Epub 2019 Feb 8. PMID: 30736810 Abstract Title: Diabetic encephalopathy: beneficial effects of supplementation with fatty acidsω3 and nordihydroguaiaretic acid in a spontaneous diabetes rat model. Abstract: BACKGROUND: Diabetic encephalopathy is a chronic complications of diabetes mellitus that affects the central nervous system. We evaluated the effect …
Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.
PMID: NPJ Aging Mech Dis. 2019 ;5:7. Epub 2019 Oct 2. PMID: 31602311 Abstract Title: Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. Abstract: Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules. The natural …
Short-term Ubiquinol-10 supplementation alleviates tissue damage in muscle and fatigue caused by strenuous exercise in male distance runners.
PMID: Int J Vitam Nutr Res. 2020 Jan 31:1-10. Epub 2020 Jan 31. PMID: 32003645 Abstract Title: Short-term Ubiquinol-10 supplementation alleviates tissue damage in muscle and fatigue caused by strenuous exercise in male distance runners. Abstract: Coenzyme Q10 (CoQ10) is the electron transporter in oxidative phosphorylation and an endogenous antioxidant. Recent researches have indicated that …
Beneficial effect of ubiquinol on hematological and inflammatory signaling during exercise.
PMID: Nutrients. 2020 Feb 6 ;12(2). Epub 2020 Feb 6. PMID: 32041223 Abstract Title: Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise. Abstract: Strenuous exercise (any activity that expends six metabolic equivalents per minute or more causing sensations of fatigue and exhaustion to occur, inducing deleterious effects, affecting negatively different cells), induces …
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