PMID: Food Chem Toxicol. 2014 Mar ;65:242-51. Epub 2013 Dec 31. PMID: 24384411 Abstract Title: Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis. Abstract: To examine the mechanisms by which licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in …
Author Archives: Taylor Mercado
Immunomodulatory effects of licochalcone A on experimental autoimmune encephalomyelitis.
PMID: J Pharm Pharmacol. 2014 Jun ;66(6):886-94. Epub 2014 Jan 22. PMID: 24447171 Abstract Title: Immunomodulatory effects of licochalcone A on experimental autoimmune encephalomyelitis. Abstract: OBJECTIVES: Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. Herein, we have investigated the immunomodulatory effect of licochalcone A (LicoA) on NO, H2 O2 …
Antimetastatic effects of licochalcone B on human bladder carcinoma T24 by inhibition of matrix metalloproteinases-9 and NF-кB activity.
n/a PMID: Basic Clin Pharmacol Toxicol. 2014 Dec ;115(6):527-33. Epub 2014 Jul 1. PMID: 25099010 Abstract Title: Antimetastatic effects of licochalcone B on human bladder carcinoma T24 by inhibition of matrix metalloproteinases-9 and NF-кB activity. Abstract: This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder …
Role of licochalcone C in cardioprotection against ischemia/reperfusion injury.
PMID: Life Sci. 2015 Jul 1 ;132:27-33. Epub 2015 Apr 25. PMID: 25921769 Abstract Title: Role of licochalcone C in cardioprotection against ischemia/reperfusion injury of isolated rat heart via antioxidant, anti-inflammatory, and anti-apoptotic activities. Abstract: AIMS: This study aimed to evaluate the protective effect of licochalcone C against myocardial ischemia/reperfusion injury in rats.MAIN METHODS: Left …
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Phytochemical licochalcone A enhances antimalarial activity of artemisinin in vitro.
PMID: Acta Trop. 2009 Mar ;109(3):194-8. Epub 2008 Nov 20. PMID: 19063856 Abstract Title: Phytochemical licochalcone A enhances antimalarial activity of artemisinin in vitro. Abstract: Resistance to synthetic first-line antimalarial drugs is considered to be a major cause of increased malaria morbidity and mortality. Use of artemisinin-based combination therapies (ACTs) is being encouraged to reduce …
Licochalcone E has an antidiabetic effect.
PMID: J Nutr Biochem. 2012 Jul ;23(7):759-67. Epub 2011 Aug 12. PMID: 21840191 Abstract Title: Licochalcone E has an antidiabetic effect. Abstract: Licochalcone E (lico E) is a retrochalcone isolated from the root of Glycyrrhiza inflata. Retrochalcone compounds evidence a variety of pharmacological profiles, including anticancer, antiparasitic, antibacterial, antioxidative and superoxide-scavenging properties. In this study, …
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Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A.
PMID: Immunopharmacol Immunotoxicol. 2013 Dec ;35(6):653-61. Epub 2013 Sep 12. PMID: 24028304 Abstract Title: Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A. Abstract: CONTEXT: Licochalcone A (Lico A) is a major and biogenetically characteristic chalcone isolated from the root of Xinjiang liquorice, Glycyrrhiza inflata.OBJECTIVE: We focused on investigating whether …
The current study demonstrated that licochalcone C may be a potential adjuvant therapeutic agent for bladder cancer.
PMID: Mol Med Rep. 2015 Nov ;12(5):7623-8. Epub 2015 Sep 22. PMID: 26397392 Abstract Title: Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells. Abstract: The current study investigated the mechanisms by which licochalcone C induces apoptosis of T24 human malignant bladder cancer cells. Cell viability was evaluated using an MTT …
Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways.
PMID: Int J Oncol. 2016 Apr ;48(4):1749-57. Epub 2016 Feb 1. PMID: 26847145 Abstract Title: Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways. Abstract: Licochalcone B (Lico B), which belongs to the retrochalcone family, is isolated from the roots of Chinese licorice. Lico B has been reported …
Licochalcone B arrests cell cycle progression and induces apoptosis in human breast cancer MCF-7 cells.
PMID: Recent Pat Anticancer Drug Discov. 2016 ;11(4):444-452. PMID: 27719653 Abstract Title: Licochalcone B Arrests Cell Cycle Progression and Induces Apoptosis in Human Breast Cancer MCF-7 Cells. Abstract: BACKGROUND: Recent patent of licochalcone B (LCB) as an antiinflammatory agent has been developed. Emerging evidence shows that LCB may be a promising alternative compound with anti-cancer …
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