Taylor Mercado

Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice.

PMID: Iran J Basic Med Sci. 2016 Aug ;19(8):910-915. PMID: 27746874 Abstract Title: Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice. Abstract: OBJECTIVES: The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl)-induced liver toxicity.MATERIALS AND METHODS: Hepatotoxicity …

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Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling.

PMID: Iran J Basic Med Sci. 2017 Feb ;20(2):131-137. PMID: 28293388 Abstract Title: Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling. Abstract: OBJECTIVES: Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to …

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Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells.

PMID: Oncol Lett. 2017 May ;13(5):3662-3668. Epub 2017 Mar 16. PMID: 28521469 Abstract Title: Licochalcone-E induces caspase-dependent death of human pharyngeal squamous carcinoma cells through the extrinsic and intrinsic apoptotic signaling pathways. Abstract: The aim of the present study was to investigate licochalcone-E (Lico-E)-induced apoptosis and the associated apoptotic signaling pathway in FaDu cells, a …

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Licochalcone E protects against carbon tetrachloride‑induced liver toxicity.

PMID: Mol Med Rep. 2017 Oct ;16(4):5269-5276. Epub 2017 Aug 17. PMID: 28849019 Abstract Title: Licochalcone E protects against carbon tetrachloride‑induced liver toxicity by activating peroxisome proliferator-activated receptor gamma. Abstract: The present study aimed to investigate the hepatoprotective role of Licochalcone E (LCE) and its mechanism of action in a mouse model of carbon tetrachloride (CCl4)‑induced …

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Licochalcone B induced extrinsic and intrinsic apoptosis in human skin melanoma (A375) and squamous cell carcinoma (A431) cells.

PMID: Phytother Res. 2017 Dec ;31(12):1858-1867. Epub 2017 Oct 13. PMID: 29027311 Abstract Title: Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells. Abstract: Licochalcone B (Lico B), which is normally isolated from the roots of Glycyrrhiza inflata (Chinese Licorice), generally classified into organic …

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Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells.

PMID: Oncol Rep. 2018 May ;39(5):2160-2170. Epub 2018 Mar 20. PMID: 29565458 Abstract Title: Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells. Abstract: The aim of the present study was to determine the effects of Licochalcone D (LD) on the apoptosis and migration and invasion in human melanoma A375 cells. Cell …

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Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma.

PMID: J Cell Physiol. 2019 02 ;234(2):1780-1793. Epub 2018 Aug 2. PMID: 30070696 Abstract Title: Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma. Abstract: Licochalcone (LC) families have been reported to have a wide range of biological function such as antioxidant, antibacterial, antiviral, and anticancer effects. Although various beneficial …

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Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells.

PMID: J Cell Biochem. 2018 12 ;119(12):10118-10130. Epub 2018 Aug 20. PMID: 30129052 Abstract Title: Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells by regulation of the JAK2/STAT3 signaling pathway. Abstract: Oral cancer is of an aggressive malignancy that arises on oral cavity and lip, 90% of cancers histologically originated in the …

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Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3.

PMID: Oncol Rep. 2019 Jan ;41(1):333-340. Epub 2018 Oct 11. PMID: 30320347 Abstract Title: Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3. Abstract: Licochalcone H (LCH) is a chemical compound that is a positional isomer of licochalcone C (LCC), a chalconoid isolated from the root of Glycyrrhiza inflata, which has …

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Sabadine exhibits anti-coronavirus activity.

PMID: J Med Chem. 2004 Feb 26 ;47(5):1079-80. PMID: 14971887 Abstract Title: Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design. Abstract: A novel human coronavirus has been reported to be the causative agent of severe acute respiratory syndrome (SARS). Since replication of HcoVs depends on extensive proteolytic processing, the main proteinase, 3CLpro, …

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