Author Archives: Taylor Mercado

PMID:  Chem Pharm Bull (Tokyo). 2005 Feb ;53(2):244-7. PMID: 15684529 Abstract Title:  Bioactive pyranoxanthones from the roots of Calophyllum blancoi. Abstract:  Phytochemical investigation of the roots of Calophyllum blancoi growing in Taiwan resulted in the isolation of three new pyranoxanthones, blancoxanthone (1), acetyl blancoxanthone (2) and 3-hydroxyblancoxanthone (3), in addition to two known pyranoxanthones, pyranojacaeubin …

Continue reading “Xanthones from the roots of Calophyllum blancoi exhibit significant anti-coronavirus activity.”

PMID:  Chin Med J (Engl). 2005 Mar 20 ;118(6):493-6. PMID: 15788131 Abstract Title:  Antiviral activity of cepharanthine against severe acute respiratory syndrome coronavirus in vitro. Abstract:  [n/a] read more

PMID:  Antiviral Res. 2005 Oct ;68(1):36-42. PMID: 16115693 Abstract Title:  Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Abstract:  The 3C-like protease (3CLpro) of SARS-coronavirus mediates the proteolytic processing of replicase polypeptides 1a and 1ab into functional proteins, becoming an important target for the drug development. In this study, Isatis …

Continue reading “Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.”

PMID:  Clin Exp Pharmacol Physiol. 2006 Jul ;33(7):612-6. PMID: 16789928 Abstract Title:  Antiviral effects of saikosaponins on human coronavirus 229E in vitro. Abstract:  1. Saikosaponins represent a group of oleanane derivatives, usually as glucosides, that are found in a number of plant families. Saikosaponins isolated from medicinal plants such as Bupleurum spp., Heteromorpha spp. and …

Continue reading “Antiviral effects of saikosaponins on human coronavirus 229E in vitro.”

PMID:  Bioorg Med Chem. 2006 Dec 15 ;14(24):8295-306. Epub 2006 Oct 12. PMID: 17046271 Abstract Title:  Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features. Abstract:  The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is one of the most promising targets for discovery …

Continue reading “In this study, a natural compound called quercetin-3-beta-galactoside was identified as an inhibitor of the SARA-coronavirus protease.”

PMID:  J Asian Nat Prod Res. 2007 Jan-Feb;9(1):59-65. PMID: 17365191 Abstract Title:  Bioactive coumarins from Boenninghausenia sessilicarpa. Abstract:  Bioassay guided fractionation of Boenninghausenia sessilicarpa (Rutaceae) resulted in the isolation of a new dimeric coumarin glucoside 9'-methoxyl rutarensin (1) and a cytotoxic compound rutamarin (4), as well as an antivirus component leptodactylone (8), together with six …

Continue reading “Leptodactylone, an antiviral constituents of Boenninghausenia sessilicarpa, shows potent protective activity of cells against SARS-coronavirus.”

PMID:  J Clin Virol. 2008 Feb ;41(2):122-8. Epub 2007 Nov 26. PMID: 18036887 Abstract Title:  In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex. Abstract:  BACKGROUND: A search for new anti-coronaviral drugs to treat coronaviral infections was motivated by an outbreak of …

Continue reading “In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex.”

PMID:  Antiviral Res. 2009 Jan ;81(1):77-81. Epub 2008 Nov 6. PMID: 18992773 Abstract Title:  Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus. Abstract:  Porcine epidemic diarrhea virus (PEDV) is the predominant cause of severe entero-pathogenic diarrhea in swine. The lack of effective therapeutical treatment underlines the importance of research for new antivirals. In …

Continue reading “Quercetin 7-rhamnoside displays antiviral activity against porcine epidemic diarrhea virus (coronavirus.”

PMID:  Virus Res. 2010 Apr ;149(1):86-94. Epub 2010 Jan 21. PMID: 20096315 Abstract Title:  Avian coronavirus infectious bronchitis virus susceptibility to botanical oleoresins and essential oils in vitro and in vivo. Abstract:  Anti-coronaviral activity of a mixture of oleoresins and essential oils from botanicals, designated QR448(a), was examined in vitro and in vivo. Treatment of …

Continue reading “Avian coronavirus infectious bronchitis virus are susceptible to botanical oleoresins and essential oils in vitro and in vivo.”

PMID:  Int J Food Microbiol. 2010 Jul 31 ;141 Suppl 1:S91-7. Epub 2010 Jan 4. PMID: 20106541 Abstract Title:  Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection. Abstract:  This study aimed to examine the potential antiviral activity of lactic acid bacteria (LAB) using animal and human …

Continue reading “Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection including transmissible gastroenteritis virus (coronavirus).”